Short-term glucocorticoid intake improves exercise endurance in healthy recreationally trained women

Panse, B. Le; Thomasson, Rémi; Jollin, L.; Lecoq, A.-M.; Amiot, Virgile; Rieth, N.; Céaurriz, J. de; Collomp, K.

doi:10.1007/s00421-009-1149-8

Cited by 29 publications

(37 citation statements)

References 26 publications

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“…Although the statistical comparison was made between baseline measurement and post-treatment, and not additionally to the placebo measurements, it seems likely that this is a true effect as there was no change in the placebo treatment. Another study confirmed these findings in untrained females treated with 50 mg prednisone daily for 1 week, which showed a 39% increase (18.5 min) in cycling time to exhaustion [123]. However, it should be noted that it is unclear how time to exhaustion relates to real-life endurance performance, which is usually not until exhaustion but until a finish line is reached.…”

Section: Resultsmentioning

confidence: 74%

Review of WADA Prohibited Substances: Limited Evidence for Performance-Enhancing Effects

Heuberger

Cohen

2018

Sports Med

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The World Anti-Doping Agency is responsible for maintaining a Prohibited List that describes the use of substances and methods that are prohibited for athletes. The list currently contains 23 substance classes, and an important reason for the existence of this list is to prevent unfair competition due to pharmacologically enhanced performance. The aim of this review was to give an overview of the available evidence for performance enhancement of these substance classes. We searched the scientific literature through PubMed for studies and reviews evaluating the effects of substance classes on performance. Findings from double-blind, randomized controlled trials were considered as evidence for (the absence of) effects if they were performed in trained subjects measuring relevant performance outcomes. Only 5 of 23 substance classes show evidence of having the ability to enhance actual sports performance, i.e. anabolic agents, β2-agonists, stimulants, glucocorticoids and β-blockers. One additional class, growth hormone, has similar evidence but only in untrained subjects. The observed effects all relate to strength or sprint performance (and accuracy for β-blockers); there are no studies showing positive effects on reliable markers of endurance performance. For 11 classes, no well-designed studies are available, and, for the remaining six classes, there is evidence of an absence of a positive effect. In conclusion, for the majority of substance classes, no convincing evidence for performance enhancement is available, while, for the remaining classes, the evidence is based on a total of only 266 subjects from 11 studies.

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Section: Resultsmentioning

confidence: 74%

Review of WADA Prohibited Substances: Limited Evidence for Performance-Enhancing Effects

Heuberger

Cohen

2018

Sports Med

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“…In conclusion, the mechanisms by which short‐term administration of glucocorticoids are able to improve exercise performance is not completely understood [52,56,58,64]. However, single, acute doses do not appear to have the same performance‐enhancing effect as systematic short‐term administration, despite having similar alterations in blood hormonal and metabolic parameters.…”

Section: Resultsmentioning

confidence: 94%

“…As a consequence glucocorticoids have the potential to be used as ergogenic aids [51]. Table 3 [52‐60] summaries the current available evidence of the effect of glucocorticoids on exercise performance. In 2 separate studies, Arlettaz et al [52] and Le Panse et al [58] investigated the effects of 7 days of prednisolone administration (oral dose 60 mg/d and 50 mg/d, respectively) on exercise performance during submaximal exercise (time to exhaustion at 70%‐75% VO 2max ).…”

Section: Resultsmentioning

confidence: 99%

Analgesics and Sport Performance: Beyond the Pain‐Modulating Effects

Holgado

Hopker

Sanabria

et al. 2017

PM&R

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1Analgesics are widely used in sport to treat pain and inflammation associated with injury. However, there 2 is growing evidence that some athletes might be taking these substances in an attempt to enhance Introduction 18There is little doubt that when exercise is performed above certain intensities, or over a prolonged period 19 of time, it causes feeling of pain and discomfort. Sayings such as 'no pain, no gain' are often heard in 20 relation to both training and competition settings across a variety of different sports. Indeed, these 21 feelings of exercise-induced pain have been shown to have a negative effect on training and performance 22 [1]. As a consequence, there has been a trend for athletes from all levels and ages to use pharmacological 23 analgesics substances prior to training and competition up to 4-fold more than their age-matched general 24 population [2]. The general term analgesic covers a variety of different pharmacological substances, 25 including non-steroidal anti-inflammatory drugs (NSAIDs), non-opioid analgesic (such as paracetamol 26 2 and others), weak opioids (for example tramadol, codeine or morphine [3]) and orally administered or 27 injected glucorticosteroids [4,5]. Indeed, paracetamol and NSAIDs are one of the most recurrent groups 28 of pharmacological substances used by athletes ranging from 11 up to 92% [6,7]. For instance, it is 29 common for athletes with minor injuries to continue training and even competing, by treating their minor 30 health issues with analgesic [8]. 31The aforementioned negative association between pain and exercise capacity increases the likelihood of 32 analgesic use as a method to increase the level of performance during competition [5,9]. Furthermore, the 33 trends for more frequent use of analgesics in-competition vs. out-competition, use of more than one drug 34 at the same time, and administration of these medications at supratherapeutic dosages, all suggest athletes 35 may be using these analgesics as ergogenic aids [4,5]. Therefore, in contrast to the post-exercise use of 36 analgesics to accelerate recovery, there is potential for their prophylactic use as a potential performance 37 enhancing intervention. In comparison to what is known about the use of analgesics for treating sporting 38 injury [10,11], much less is known about their effects on exercise related physiology and performance 39 [12][13][14]. However, as analgesics exert a pharmacological action on key physiological systems related to 40 exercise performance, a theoretical rationale exists whereby these drugs could provide a significant 41 ergogenic effect. 42 Material and methods 43The aim of this manuscript was to review the literature and evaluate the evidence for the ergogenic effect 44 of analgesics, expected dosages, and potential side effects. A computer search of scientific databases 45 (PubMed, Web of Science, ScienceDirect and Scopus) was made for English language articles 46 investigating the use of analgesics in sport for all period of time up to September 2...

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“…Further studies will be necessary to explore and accurately quantify the mechanisms of proteolysis and glyconeogenesis induced by short-term glucocorticoid intake during this type of exercise. nately, free fatty acids (FFAs) and BCAA were not measured either in this study or in the others performed during more intense submaximal exercise after short-term glucocorticoid intake [5,6] . The purpose of the present study was therefore to characterize the eff ects of short-term (1 week), therapeutic glucocorticoid administration (i. e., prednisone, 50 mg / day orally) on plasma amino acids, FFAs, blood glucose, and several hormones in healthy volunteers performing long-lasting exercise.…”

Section: Introduction ▼mentioning

confidence: 79%

Short-term Glucocorticoid Intake and Metabolic Responses During Long-lasting Exercise

Thomasson¹,

Rieth²,

Jollin³

et al. 2011

Horm Metab Res

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The aim of the study was to evaluate the effects of short-term glucocorticoid treatment on plasma amino acids, free fatty acids, blood glucose, and several hormones in healthy volunteers performing long-lasting exercise. 9 young female subjects exercised 2 h at 50-55% VO₂ max twice, once after placebo (Pla) ingestion and once after prednisone (Cor, 50 mg/day/7 days) ingestion, according to a double-blind and randomized protocol. Blood samples were tat rest and during exercise for measurement of amino acids, free fatty acids, blood glucose, adrenocorticotrophic hormone (ACTH), growth hormone, dehydroepiandrosterone (DHEA), insulin, and glucagon. Both ACTH and DHEA values were significantly decreased by Cor vs. Pla (p < 0.01) throughout exercise, and Cor intake also induced lower growth hormone concentrations vs. Pla (p < 0.05) from 60 min to the end of exercise. No significant difference in glucagon, insulin or free fatty acid values was found between the treatments. Branched-chain amino acids and other essential amino acids were significantly higher after Cor vs. Pla from 60 min to the end of exercise (p < 0.05), whereas blood glucose was significantly higher from 90 min to the end of exercise (p < 0.05). We conclude that short-term glucocorticoid intake induces marked hormonal and metabolic changes during long-lasting exercise. Proteolysis can increase with glucocorticoid during this type of exercise and the related higher plasma amino acid concentrations may contribute as energy substrates. Further studies will be necessary to explore and accurately quantify the mechanisms of proteolysis and glyconeogenesis induced by short-term glucocorticoid intake during this type of exercise.

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Short-term glucocorticoid intake improves exercise endurance in healthy recreationally trained women

Cited by 29 publications

References 26 publications

Review of WADA Prohibited Substances: Limited Evidence for Performance-Enhancing Effects

Review of WADA Prohibited Substances: Limited Evidence for Performance-Enhancing Effects

Analgesics and Sport Performance: Beyond the Pain‐Modulating Effects

Short-term Glucocorticoid Intake and Metabolic Responses During Long-lasting Exercise

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