Short‐term high temperature treatment reduces viability and inhibits respiration and DNA repair enzymes in <scp><i>Araucaria angustifolia</i></scp> cells

Furlanetto, Ana L.D.M.; Cadena, Sílvia Maria Suter Correia; Martinez, Gláucia Regina; Ferrando, Beatriz; Stevnsner, Tinna

doi:10.1111/ppl.12793

Cited by 6 publications

(7 citation statements)

References 45 publications

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“…In vivo targeting of UNG-GFP fusions and in vitro import assays showed that UNG from Arabidopsis is imported into mitochondria [102]. UNG activity was also found associated to maize and potato mitochondrial fractions [103,104], and in organello experiments revealed UNG in the mitochondria of Arabidopsis, potato, and in the gymnosperm Araucaria angustifolia [102,105].…”

Section: Figure 1 Mechanisms Of Base Excision Repair (Ber)mentioning

confidence: 96%

“…The Medicago truncatula and Arabidopsis FPG possess a nuclear localization signal [107,110], but the FPG gene can be expressed into seven different mRNAs by alternative splicing [111] and it is possible that some code for organellar isoforms of FPG. The presence of NEI glycosylase activity has recently been characterized in mitochondrial extracts of potato and A. angustifolia [104,105]. Interestingly, Cordoba-Canero et al (2014) found an increase in oxidative damage in both nuclear and mitochondrial DNA from fpg ogg1 Arabidopsis double mutants, but not in single mutants, suggesting that one glycosylase can compensate the absence of the other [106].…”

Section: Figure 1 Mechanisms Of Base Excision Repair (Ber)mentioning

confidence: 99%

“…The abasic sites left by glycosylases are cleaved by an AP endonuclease, leading to a 5 -deoxyribose phosphate (5 -dR-P) moiety in the case of the products of monofunctional glycosylase, or to 5 -OH and 3 -P termini after action of a bifunctional glycosylase (Figure 1). AP-endonuclease activity was detected in Arabidopsis, potato, and A. angustifolia mitochondria [102,104,105], and the enzyme might be the product of the apurinic endonuclease-redox protein (ARP) gene. Interestingly, Ferrando et al (2019) detected an induction of the potato mitochondrial APE1-like activity under hypoxia [104].…”

Section: Figure 1 Mechanisms Of Base Excision Repair (Ber)mentioning

confidence: 99%

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DNA Repair and the Stability of the Plant Mitochondrial Genome

Chevigny

Schatz-Daas

Lotfi

et al. 2020

IJMS

120

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The mitochondrion stands at the center of cell energy metabolism. It contains its own genome, the mtDNA, that is a relic of its prokaryotic symbiotic ancestor. In plants, the mitochondrial genetic information influences important agronomic traits including fertility, plant vigor, chloroplast function, and cross-compatibility. Plant mtDNA has remarkable characteristics: It is much larger than the mtDNA of other eukaryotes and evolves very rapidly in structure. This is because of recombination activities that generate alternative mtDNA configurations, an important reservoir of genetic diversity that promotes rapid mtDNA evolution. On the other hand, the high incidence of ectopic recombination leads to mtDNA instability and the expression of gene chimeras, with potential deleterious effects. In contrast to the structural plasticity of the genome, in most plant species the mtDNA coding sequences evolve very slowly, even if the organization of the genome is highly variable. Repair mechanisms are probably responsible for such low mutation rates, in particular repair by homologous recombination. Herein we review some of the characteristics of plant organellar genomes and of the repair pathways found in plant mitochondria. We further discuss how homologous recombination is involved in the evolution of the plant mtDNA.

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Section: Figure 1 Mechanisms Of Base Excision Repair (Ber)mentioning

confidence: 96%

Section: Figure 1 Mechanisms Of Base Excision Repair (Ber)mentioning

confidence: 99%

Section: Figure 1 Mechanisms Of Base Excision Repair (Ber)mentioning

confidence: 99%

See 1 more Smart Citation

DNA Repair and the Stability of the Plant Mitochondrial Genome

Chevigny

Schatz-Daas

Lotfi

et al. 2020

IJMS

120

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“…Chloroplast DNA glycosylase AtNTH1 (endonuclease III homolog 1) has been shown to incise a UV-irradiated supercoiled DNA but not undamaged DNA [123]. Activity of AP endonuclease was confirmed in mitochondria of Arabidopsis, potato and Araucaria angustifolia [115,122,124].…”

Section: Base Excision Repairmentioning

confidence: 99%

The Dark Side of UV-Induced DNA Lesion Repair

Strzałka

Zgłobicki

Kowalska

et al. 2020

Genes

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In their life cycle, plants are exposed to various unfavorable environmental factors including ultraviolet (UV) radiation emitted by the Sun. UV-A and UV-B, which are partially absorbed by the ozone layer, reach the surface of the Earth causing harmful effects among the others on plant genetic material. The energy of UV light is sufficient to induce mutations in DNA. Some examples of DNA damage induced by UV are pyrimidine dimers, oxidized nucleotides as well as single and double-strand breaks. When exposed to light, plants can repair major UV-induced DNA lesions, i.e., pyrimidine dimers using photoreactivation. However, this highly efficient light-dependent DNA repair system is ineffective in dim light or at night. Moreover, it is helpless when it comes to the repair of DNA lesions other than pyrimidine dimers. In this review, we have focused on how plants cope with deleterious DNA damage that cannot be repaired by photoreactivation. The current understanding of light-independent mechanisms, classified as dark DNA repair, indispensable for the maintenance of plant genetic material integrity has been presented.

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“…In addition, in vitro targeting assays have also revealed that a transiently expressed AtUNG-GFP fusion protein in Nicotiana benthamiana leaves is readily colocalized with mitochondria in protoplasts generated from the agro-infiltrated tissues ( Boesch et al, 2009 ). Moreover, some in-organelle experiments have further indicated the presence of UNG activity in the mitochondria in Arabidopsis , potato, and also in the gymnosperm Araucaria angustifolia , respectively ( Boesch et al, 2009 ; Furlanetto et al, 2019 ).…”

Section: Dna Damage Repair Mechanisms In Plant Mitochondria and Chloroplastmentioning

confidence: 99%

An Insight Into the Mechanism of Plant Organelle Genome Maintenance and Implications of Organelle Genome in Crop Improvement: An Update

Mahapatra

Banerjee

et al. 2021

Front. Cell Dev. Biol.

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Besides the nuclear genome, plants possess two small extra chromosomal genomes in mitochondria and chloroplast, respectively, which contribute a small fraction of the organelles’ proteome. Both mitochondrial and chloroplast DNA have originated endosymbiotically and most of their prokaryotic genes were either lost or transferred to the nuclear genome through endosymbiotic gene transfer during the course of evolution. Due to their immobile nature, plant nuclear and organellar genomes face continuous threat from diverse exogenous agents as well as some reactive by-products or intermediates released from various endogenous metabolic pathways. These factors eventually affect the overall plant growth and development and finally productivity. The detailed mechanism of DNA damage response and repair following accumulation of various forms of DNA lesions, including single and double-strand breaks (SSBs and DSBs) have been well documented for the nuclear genome and now it has been extended to the organelles also. Recently, it has been shown that both mitochondria and chloroplast possess a counterpart of most of the nuclear DNA damage repair pathways and share remarkable similarities with different damage repair proteins present in the nucleus. Among various repair pathways, homologous recombination (HR) is crucial for the repair as well as the evolution of organellar genomes. Along with the repair pathways, various other factors, such as the MSH1 and WHIRLY family proteins, WHY1, WHY2, and WHY3 are also known to be involved in maintaining low mutation rates and structural integrity of mitochondrial and chloroplast genome. SOG1, the central regulator in DNA damage response in plants, has also been found to mediate endoreduplication and cell-cycle progression through chloroplast to nucleus retrograde signaling in response to chloroplast genome instability. Various proteins associated with the maintenance of genome stability are targeted to both nuclear and organellar compartments, establishing communication between organelles as well as organelles and nucleus. Therefore, understanding the mechanism of DNA damage repair and inter compartmental crosstalk mechanism in various sub-cellular organelles following induction of DNA damage and identification of key components of such signaling cascades may eventually be translated into strategies for crop improvement under abiotic and genotoxic stress conditions. This review mainly highlights the current understanding as well as the importance of different aspects of organelle genome maintenance mechanisms in higher plants.

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Short‐term high temperature treatment reduces viability and inhibits respiration and DNA repair enzymes in Araucaria angustifolia cells

Cited by 6 publications

References 45 publications

DNA Repair and the Stability of the Plant Mitochondrial Genome

DNA Repair and the Stability of the Plant Mitochondrial Genome

The Dark Side of UV-Induced DNA Lesion Repair

An Insight Into the Mechanism of Plant Organelle Genome Maintenance and Implications of Organelle Genome in Crop Improvement: An Update

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