Short-term ibuprofen to prevent ossification after hip arthroplasty:No effects in a prospective randomized study of 47 arthrosis cases

Heterotopic ossification after hip arthroplasty:A randomized double-blind multicenter study of tenoxicam in 147 hips

“…Two randomized studies have reported shorter treatment periods, one with a 2 weeks' treatment period with indomethacin, where the reduction in heterotopic ossification was found to be significant and one with a I0-day treatment period with ibuprofen, in which there was no significant reduction in the ibuprofen-treated group (Kjaersgaard-Andersen et al 1993, Ahrengart et al 1994. This is the first prospective randomized study showing that a non-steroidal anti-inflammatory drug given for as short a period as 5 days can reduce heterotopic ossification after cemented total hip arthroplasty.…”

Optimal Timing of Preoperative Radiation for Prophylaxis Against Heterotopic Ossification

“…Despite its high prevalence and multiple clinical studies of the complication, the pathophysiology of heterotopic ossification remains unclear 15,[33][34][35][36][37][38][39][40][41] . Nonetheless, both local and systemic measures have been established to provide effective prophylaxis against heterotopic ossification following hip surgery [6][7][8][9][10][11][12][13][14][16][17][18][19][33][34][35][36][37][38][39][40][41][42][43][44][45] . Although nonsteroidal anti-inflammatory agents are effective in preventing heterotopic ossification, systemic and local gastrointestinal side-effects often limit their usefulness 8,11,16,46 .…”

“…Analysis of the ratios of low-grade (0, I, and II) to high-grade (III and IV) heterotopic ossification in the groups further sup-ported the superior efficacy of the treatment given twenty-four hours preoperatively. Authors of clinical studies of prophylaxis against heterotopic ossification [5][6][7][8]12,17,18 have commonly reported the frequency of heterotopic ossification on the basis of two classifications of severity (grades I and II compared with grades III and IV). A similar analysis of our data showed an even stronger advantage of radiation administered twentyfour hours preoperatively as opposed to four hours (p = 0.02), seventy-two hours (p = 0.002), or three weeks (p = 0.03) preoperatively.…”

“…Nearly 10% of patients with heterotopic ossification experience functional impairment such as pain and a decreased range of motion related to the inflammatory reaction that accompanies this condition [1][2][3][4][5] . Prophylactic methods aimed at inhibiting heterotopic ossification have included pharmacological measures and radiation therapy [6][7][8][9][10][11][12][13][14][15][16][17][18][19] .…”

Intra- and Periarticular Heterotopic Ossification in the Knee After a Low-Velocity Gunshot Wound Treated With Retrograde Intramedullary Nailing of the Femur

“…Heterotopic ossification (HO) has been reported as a complication after many orthopaedic procedures, including total hip arthroplasty, [1][2][3][4][5] open reduction and internal fixation of acetabular fractures, 6,7 antegrade intramedullary femoral nailing, [8][9][10][11] intramedullary tibial nailing, 12,13 high-velocity wounds sustained during combat, 14,15 and polytrauma after traumatic brain injury. 16,17 HO is more commonly reported in the hip 16 and elbow 16,18 compared with other joints.…”