Short-Term Impact of Atmospheric Pollution on Fecundability

Slama, Rémy; Bottagisi, Sébastien; Solanský, Ivo; Lepeule, Johanna; Giorgis-Allemand, Lise; Šrám, Radìm J.

doi:10.1097/ede.0b013e3182a702c5

Cited by 82 publications

(50 citation statements)

References 40 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Overall, couples who took longer to conceive or were infertile tended to live closer to major roadways in our study, but we lacked statistical power to observe a significant association at close distances or for prospectively measured infertility. These findings are consistent with other investigations showing decrements in fertility rates (8), fecundability (9) and IVF treatment success (10;11) associated with traffic-related pollutant exposures.…”

Section: 0 Discussionsupporting

confidence: 93%

“…The only population-based study of fertility and traffic-related air pollutant exposure found a 13% reduction in fertility rates among women aged 15-44 years in Barcelona, Spain in 2011-2012 associated with coarse particles using a land-use regression model and vital statistics data(8). Couple-based fecundability was assessed in Teplice, where pregnancy in the first month of unprotected intercourse was less likely when couples were exposed to higher levels of nitrogen dioxide (NO 2 ) and PM 2.5 (9). NO 2 was associated with lower live birth rates and PM 2.5 with decreased conception rates after in vitro fertilization (IVF),(10) whereas miscarriage rates appeared higher in couples exposed to the highest quartile of PM exposure prior to IVF or embryo transfer(11).…”

Section: 0 Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Proximity to major roadways and prospectively-measured time-to-pregnancy and infertility

Mendola

Sundaram

Louis

et al. 2017

Science of The Total Environment

View full text Add to dashboard Cite

We aimed to study the potential impact of proximity to major roadways on time-to-pregnancy and infertility in couples attempting pregnancy in the Longitudinal Investigation of Fertility and Environment (LIFE) study (2005-2009), a population-based, prospective cohort study. Couples attempting pregnancy (n=500) were enrolled and followed prospectively until pregnancy or 12 months of trying and 393 couples (78%) had complete data and full follow-up. Time-to-pregnancy was based on a standard protocol using fertility monitors, tracking estrone-3-glucuonide and luteinizing hormone, and pregnancy test kits to detect human chorionic gonadotropin (hCG). The fecundability odds ratio (FOR) and 95% confidence interval (CI) were estimated using proportional odds models. Infertility was defined as 12 months of trying to conceive without an hCG pregnancy and the relative risk (RR) and 95% CI were estimated with log-binomial regression. Final models were adjusted for age, parity, study site, and salivary alpha-amylase, a stress marker. Infertile couples (53/393; 14%) tended to live closer to major roadways on average than fertile couples (689 m vs. 843 m, respectively) but the difference was not statistically significant. The likelihood of pregnancy was increased 3% for every 200 meters further away the couples residence was from a major roadway (FOR=1.03; CI=1.01-1.06). Infertility also appeared elevated at moderate distances compared to 1000 meters or greater, but estimates lacked precision. Our findings suggest that proximity to major roadways may be related to reductions in fecundity. Prospective data from larger populations is warranted to corroborate these findings.

show abstract

Section: 0 Discussionsupporting

confidence: 93%

Section: 0 Introductionmentioning

confidence: 99%

Proximity to major roadways and prospectively-measured time-to-pregnancy and infertility

Mendola

Sundaram

Louis

et al. 2017

Science of The Total Environment

View full text Add to dashboard Cite

show abstract

“…Among the other air pollutants studied (PAH, O 3 , NO 2 ), only NO 2 levels were significantly associated with a decreased fecundability in the first month (adjusted Fecundability Ratio (FR) = 0.71 [95% CI = 0.57-0.87]) and two first months (adjusted FR: 0.72 [95% CI: 0.53-0.97])of unprotected intercourse [30]. In Barcelona, using a cross-sectional study based on registry data at census tract level and a land use regression modeling approach, Nieuwenhuijsen et al reported a statistically significant link (detailed in Table 1) between a decrease in the fertility rate (number of live births per 1000 women) and an increase in the level of air pollution, notably PM2.…”

Section: Resultsmentioning

confidence: 99%

Does air pollution play a role in infertility?: a systematic review

et al. 2017

View full text Add to dashboard Cite

Background: Air pollution is involved in many pathologies. These pollutants act through several mechanisms that can affect numerous physiological functions, including reproduction: as endocrine disruptors or reactive oxygen species inducers, and through the formation of DNA adducts and/or epigenetic modifications. We conducted a systematic review of the published literature on the impact of air pollution on reproductive function. Eligible studies were selected from an electronic literature search from the PUBMED database from January 2000 to February 2016 and associated references in published studies. Search terms included (1) ovary or follicle or oocyte or testis or testicular or sperm or spermatozoa or fertility or infertility and (2) air quality or O 3 or NO 2 or PM2.5 or diesel or SO 2 or traffic or PM10 or air pollution or air pollutants. The literature search was conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. We have included the human and animal studies corresponding to the search terms and published in English. We have excluded articles whose results did not concern fertility or gamete function and those focused on cancer or allergy. We have also excluded genetic, auto-immune or iatrogenic causes of reduced reproduction function from our analysis. Finally, we have excluded animal data that does not concern mammals and studies based on results from in vitro culture. Data have been grouped according to the studied pollutants in order to synthetize their impact on fertility and the molecular pathways involved.

show abstract

“…In humans, a few studies indicate that the particulate fraction in ambient air may impact on female fertility, including time to pregnancy [60–62]. Low grade systemic inflammation arising from exposure to ambient particle level [63] could possibly be a contributing factor.…”

Section: Discussionmentioning

confidence: 99%

Airway exposure to multi-walled carbon nanotubes disrupts the female reproductive cycle without affecting pregnancy outcomes in mice

et al. 2017

View full text Add to dashboard Cite

BackgroundThe use of multiwalled carbon nanotubes (MWCNT) is increasing due to a growing use in a variety of products across several industries. Thus, occupational exposure is also of increasing concern, particularly since airway exposure to MWCNTs can induce sustained pulmonary acute phase response and inflammation in experimental animals, which may affect female reproduction. This proof-of-principle study therefore aimed to investigate if lung exposure by intratracheal instillation of the MWCNT NM-400 would affect the estrous cycle and reproductive function in female mice.ResultsEstrous cycle regularity was investigated by comparing vaginal smears before and after exposure to 67 μg of NM-400, whereas reproductive function was analyzed by measuring time to delivery of litters after instillation of 2, 18 or 67 μg of NM-400. Compared to normal estrous cycling determined prior to exposure, exposure to MWCNT significantly prolonged the estrous cycle during which exposure took place, but significantly shortened the estrous cycle immediately after the exposed cycle. No consistent effects were seen on time to delivery of litter or other gestational or litter parameters, such as litter size, sex ratio, implantations and implantation loss.ConclusionLung exposure to MWCNT interfered with estrous cycling. Effects caused by MWCNTs depended on the time of exposure: the estrous stage was particularly sensitive to exposure, as animals exposed during this stage showed a higher incidence of irregular cycling after exposure. Our data indicates that MWCNT exposure may interfere with events leading to ovulation.

show abstract

Short-Term Impact of Atmospheric Pollution on Fecundability

Abstract: In this polluted area, we highlighted short-term decreases in a couple's ability to conceive in association with PM2.5 and NO2 levels assessed in a central monitoring station.

Cited by 82 publications

References 40 publications

Proximity to major roadways and prospectively-measured time-to-pregnancy and infertility

Proximity to major roadways and prospectively-measured time-to-pregnancy and infertility

Does air pollution play a role in infertility?: a systematic review

Airway exposure to multi-walled carbon nanotubes disrupts the female reproductive cycle without affecting pregnancy outcomes in mice

Contact Info

Product

Resources

About