Neutrophils (PMN) play a key role in eliciting congenital immune response. These cells are equipped with specific receptors that are located on the surface of their cell membrane. These receptors produce various signals which in turn help in the effective functioning of PMN. The activity of these cells may be modified by factors of endo-and exogenous origin, including xenoestrogens such as bisphenol A (BPA). The aim of this study was to evaluate the effect of BPA on the expression of CD11c, CD14, CD15, CD16, CD62L and CD284 compounds on the surface of neutrophils in women and men. The study material included PMN isolated from the whole blood. The cells were incubated in the presence of BPA and/or LPS. Flow cytometry technique was used to evaluate the expression of CD antigens. Studies of these receptors indicate that BPA, at a concentration corresponding to the serum level of this compound in healthy subjects as well as at higher doses, induces changes in the immunophenotype of PMN, which may lead to immunity disorders associated with the dysfunction of these cells. Moreover, the observed effects of xenoestrogen on the expression of CD11c, CD14, CD15, CD16, CD62L and CD284 differentiation markers on these cells are sex-independent. There has been an increase in the number of allergic diseases, diabetics, obese individuals, and cases of endocrine, neurological and sexual disorders worldwide since the twentieth century and continues to show an increasing trend. This observation can be attributed to the rapidly growing chemical pollution of the environment. Humans are constantly exposed to natural and synthetic chemical compounds. Among them, xenoestrogens, estrogen-like compounds of exogenous origin endocrine disrupting compounds (EDCs), play an important role. They have the ability to interact with the hormonal system and modulate its functions in a manner that is characteristic for estrogens. Sources of xenoestrogens include some pharmaceutical compounds, metals, detergents, and chemicals used to harden plastics, such as bisphenol A (BPA) 1-7. The popularity of plastic products has lead to the widespread use of BPA. BPA easily penetrates into food and beverages at elevated temperatures or as a result of damage caused at the time of packaging. Humans are exposed to this compound mainly through food products, and the absorption is found to be particularly high in children. BPA is known to exert harmful effects on human health even at low concentrations. This factor disturbs the hormonal homeostasis of the organism, leading to infertility and cancers 4,5,8-10. Bisphenol A can affect the body functions through complex and still not fully understood mechanisms, including both the interaction with receptors and the influence on the permeability of cell membranes. There is evidence to prove that low levels of BPA cause negative effects on the female hormone estrogen, consequently causing a disruption of the hormonal balance in the body. The chemical structure of BPA is similar to that of phenol, thus enabling it to act ...