WANG, JACK, BLANDINE LAFERRÈ RE, JOHN C. THORNTON, RICHARD N. PIERSON, JR., and F. XAVIER PI-SUNYER. Regional subcutaneous-fat loss induced by caloric restriction in obese women. Obes Res. 2002;10:885-890. Objective: With anthropometric models using skinfolds and circumferences, we studied changes in the percentage of subcutaneous fat in the total cross-sectional area (SF%) at four body sites in obese women, before and after weight loss induced by 6 months of caloric restriction.
Research Methods and Procedures:In 61 obese women [31 African Americans and 30 whites; ages, 24 to 68 years; body mass index (BMI), Ն28kg/m 2 ], we measured SF% at the midpoint of the upper arm and thigh and the waistline and hipline, and we measured the percentage of total body fat by DXA before (Obs#1) and after (Obs#2) a 6-month nonintervention control period and then after 6 months on a 1200 kcal/d diet (Obs#3). Results: The mean body weight and BMI increased (1.8 kg and 0.61 kg/m 2 ; p ϭ 0.0001), but there were no significant changes in any other body composition measurements from Obs#1 to Obs#2. The means of Obs#3 for weight and BMI decreased by 11%, and the percentage of total body fat decreased by 13% of Obs#2 mean values (p ϭ 0.0001). The mean SF% at each site decreased 7.6% to 18.0% of the Obs#2 mean values (p Ͻ 0.001). The SF% decreases were greater at mid-arm and mid-thigh than in the cross-sectional regions at the waistline and hipline (p ϭ 0.05). There was no interaction between age or ethnicity (p Ͼ 0.2). Conclusions: In obese women, caloric restriction alone reduces anthropometrically measured subcutaneous fat proportionally more in peripheral than in central regions.