Short-Term Mitomycin C Followed By Long-Term Interferon α2β for Conjunctiva-Cornea Intraepithelial Neoplasia

Abstract

MMC (0.02%), followed by INF-alpha2beta (1 million IU/mL) 4 times a day, is an effective treatment against highly extensive CIN, in cases where surgical resection with safety margins is unfeasible.

Modern management of ocular surface squamous neoplasia

“…However, due to intolerance to further topical MMC, treatment was continued with IFN-α 2b until complete resolution of the tumor was acheived [51]. Topical MMC has been used before IFN-α 2b in an attempt to reduce the length of IFN-α 2b treatment [52]. In a case reported by Huerva et al, complete resolution of an extensive OSSN tumor was achieved after two cycles of MMC and 75 days of topical IFN-α 2b [52].…”

“…Topical MMC has been used before IFN-α 2b in an attempt to reduce the length of IFN-α 2b treatment [52]. In a case reported by Huerva et al, complete resolution of an extensive OSSN tumor was achieved after two cycles of MMC and 75 days of topical IFN-α 2b [52]. Lack of treatment efficacy with MMC and successful tumor management with 5-FU has been reported [50].…”

Conjunctival Intraepithelial Neoplasia – Clinical Presentation, Diagnosis and Treatment Possibilities

“…The lesions are well documented at the limbus occuping different degrees. Generally, in the extensive cases the cornea may be invaded (Huerva et al, 2006). The form of invasion may be variable: nodular, frothy vascular irregular extension and pedunculated and may simulate other conjunctival lesions as a pterigium or pannus .…”

“…In extensive lesions, surgical excision is difficult, and additional procedures have been employed. Extensive resections in very extensive CIN may produce a limbal stem deficiency (Huerva et al, 2006). Adjuvant radiation has the potential complications of cataracts, scleral necrosis, corneal rupture, scarring of the cornea and conjunctiva, moderate to severe conjunctivitis, and loss of eyelashes (Giaconi & Karp, 2003).…”

“…However, all sizes of lesions could be treated with topical INF alpha as the primary treatment because it is an effective, non-invasive treatment alternative to surgery that increases quality of life with low costs (Huerva et al, 2006), (Huerva et al, 2007), ). Actually, no clear consensus on the best way to manage the disorder has been established, because long-term, well designed studies are still needed.…”