Short-term Morbidities in Moderate and Late Preterm Infants

Scheuchenegger, Anna; Lechner, Evelyn; Wiesinger-Eidenberger, G; Weissensteiner, M.; Wagner, O; Schimetta, Wolfgang; Resch, Bernhard

doi:10.1055/s-0033-1355394

Cited by 15 publications

(17 citation statements)

References 15 publications

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“…In accordance with our results, in a recent study GA at birth was associated with Apgar score at fifth minute for late preterm pregnancies with placenta previa [23]. Indeed, a number of recent studies would advocate the benefits of expectant management, even for late preterm neonates [23] [28] [30] [31]. Nevertheless, after 32th week of gestation the neonatal prognosis is good [32].…”

Section: Discussionsupporting

confidence: 90%

“…However, a series of studies have demonstrated that APH is an independent factor for adverse neonatal outcomes in very preterm, as well as late preterm neonates. Among these groups APH has been independently associated with increased neonatal mortality and morbidity, particularly severe respiratory disorders, increased admission rate to NICU and increased hospital stay [28]- [31]. Our study intended to present an overview of the different causes of APH in the third trimester of pregnancy in relation to the perinatal outcome.…”

Section: Discussionmentioning

confidence: 99%

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Late Αntepartum Ηemorrhage and Neonatal Outcome: A Retrospective Study

Tsikouras¹,

Koukouli²,

Liberis³

et al. 2016

OJOG

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Objective: To retrospectively evaluate the causes, the management and neonatal outcome in pregnancies complicated with late antepartum hemorrhage (APH), defined as vaginal bleeding during the third trimester of pregnancy. Methods: We retrospectively identified all eligible patients at a single institution from January 1990 to December 2012. A thorough research was made through patients' medical and obstetrical records. The various causes of late APH were compared to each other regarding the parameters of the neonatal outcome. Multiple regression models were applied for gestational age (GA) at birth, birth weight, Apgar score at first and fifth minute and selection of modus of delivery. Results: 480 patients were included in the study, in a total of 7221 pregnancies. The causes of APH were: cervical dilatation (n = 54, 11.3%), central placental abruption (n = 57, 11.9%), peripheral placental abruption (n = 59, 12.3%), placenta previa (n = 140, 29.2%), others non-related to pregnancy (n = 42, 8.8%), uterine rupture (n = 2, 0.4%) and unknown etiology (n = 126, 26.3%). Overall, 253 neonates (52.7%) were born prematurely at gestational age below 37th week. 37 pregnancies (7.7%) resulted in giving birth prior to 32 weeks of gestation. In multivariable analysis, the cause of hemorrhage was found to be an important independent predictive factor for gestational age (GA) at birth, birth weight, Apgar scores at first and fifth minute and modus of delivery. Preeclampsia, diabetes, thyroid disorder and smoking were associated with decrease of GA at birth. Birth weight below 1500 gr and GA at birth was found to be significant independent factors for Apgar score at first and fifth minute respectively. Modus of delivery did not significantly alter Apgar score. Conclusions: Late APH required immediate evaluation of the general condition of the pregnant woman and the fetus. The cause of APH was important in the prognosis of the neonatal outcome. As long as maternal and fetal status were ensured, expectant management, instead of emergency CS, seemed to be more beneficial even for late preterm neonates.

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Section: Discussionsupporting

confidence: 90%

Section: Discussionmentioning

confidence: 99%

Late Αntepartum Ηemorrhage and Neonatal Outcome: A Retrospective Study

Tsikouras¹,

Koukouli²,

Liberis³

et al. 2016

OJOG

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“…36,37 Therefore, the significant increased risk for preterm births found after in utero exposure to SGAs (OR, 1.85; 95% CI, 1.20-2.86) may pose a significant health care issue. Furthermore, a study by Russell et al 38 (2007) reported that preterm births use significant amounts of health care resources, causing longer hospital stays, and almost 50% of the costs of infant hospitalizations.…”

Section: Discussionmentioning

confidence: 99%

Pregnancy Outcomes Following In Utero Exposure to Second-Generation Antipsychotics

Terrana

Koren

Pivovarov³

et al. 2015

Journal of Clinical Psychopharmacology

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Second-generation antipsychotics (SGAs) are increasingly used for a variety of mental illnesses; however, the data regarding the safety of these medications during pregnancy are inconclusive and contradictory. We examined the risk of adverse pregnancy outcomes associated with in utero exposure to SGAs by conducting a systematic review and meta-analysis. We searched the databases EMBASE and MEDLINE from January 1990 to December 2014. Eligible studies had to report pregnant women who took SGAs during pregnancy (first trimester exposure if analyzing congenital malformations), follow a healthy comparison group in a similar manner, and report data on pregnancy outcomes. There was no restriction on language, sample size, or publication date. The primary outcome analyzed was major congenital malformations, and secondary outcomes included miscarriages, stillbirths, preterm births, small or large for gestational age neonates, and differences in gestational ages and birth weights. A total of 12 studies met our inclusion criteria, totalling 1782 cases and 1,322,749 controls. The use of SGA during the first trimester of pregnancy was associated with a significant increased risk for major congenital malformations (odds ratio, 2.03; 95% confidence interval, 1.41-2.93); however, no specific pattern of malformations was found. An increased risk was also found for preterm births (odds ratio, 1.85; 95% CI, 1.20-2.86). The use of SGA during pregnancy was not found to be associated with an increased risk for secondary outcomes analyzed. The absence of a specific pattern of malformations makes it difficult to identify an explicit risk posed by SGAs, and therefore, further studies sufficiently controlling for confounding factors are needed to validate these findings.

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“…Among these groups APH has been independently associated with increased neonatal mortality and morbidity, particularly severe respiratory disorders, increased admission rate to NICU and increased hospital stay. [44][45][46][47] In a study conducted by Johns J et al both preterm delivery and PPROM are related with low birth weight as predictable factors. Our study demonstrated that the fetal weight was lower in the case than control group.…”

Section: Discussionmentioning

confidence: 99%

Untitled

2020

MIJOBG

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Aims and Objectives: 1 To study perinatal outcome in early pregnancy hemorrhage.2)To study perinatal outcome in late pregnancy hemorrhage. Materials and Methods: 1. This is observational prospective study performed within span of 1 year (August 2014 to July 2015) in the Department of Obstetrics and Gynaecology in ACPM Medical college, Dhule. 2 Total number of 200 women with bleeding per vaginal during pregnancy were enrolled in the study. The patients who presented with vaginal bleeding were divided into: 1 Early pregnancy bleeding < 20 weeks, 2. Late pregnancy bleeding > 20 weeks Since the demographic profile, etiology, risk factors involved, maternal and perinatal morbidities and mortalities associated with early and late pregnancy group are drastically different, so the cases in this study are divided into two groups -EARLY (<20 weeks) and LATE (>20 weeks). Results: In this study, 66% patients presented with early pregnancy bleeding and 34% with late pregnancy bleeding. Perinatal outcome in Early pregnancy bleeding:-30% spontaneous abortion, 7.6% preterm delivery, 4.5% IUGR. Perinatal outcome in Late pregnancy bleeding:-3% stillbirth, 14.7% IUGR, 5.9% IUD, 58.8% preterm birth, 2.9% early and late neonatal deaths. Conclusion: Vaginal bleeding at any stage of pregnancy is an alarming event and can be potentially life-threatening to mother and fetus. Obstetrician should ensure that patient delivers in a well equipped centre with NICU facilities and expertization of neonatologist.

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Short-term Morbidities in Moderate and Late Preterm Infants

Abstract: Nearly half of all infants suffered from any morbidity, and several risk factors were identified being significantly associated with NICU admission rate and length of hospitalization.

Cited by 15 publications

References 15 publications

Late Αntepartum Ηemorrhage and Neonatal Outcome: A Retrospective Study

Late Αntepartum Ηemorrhage and Neonatal Outcome: A Retrospective Study

Pregnancy Outcomes Following In Utero Exposure to Second-Generation Antipsychotics

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