1982
DOI: 10.1001/archpsyc.1982.04290030047009
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Short-term Naloxone Administration in Schizophrenic and Manic Patients

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1982
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Cited by 104 publications
(30 citation statements)
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“…These decreases in Bunney-Hamburg psychosis ratings and the BPRS thinking disturbance score extend the previous findings of Pickar and colleagues that short term opioid system blockade decreases positive symp toms of psychosis (Pickar et al 1981a(Pickar et al , 1981b(Pickar et al , 1982c.…”
Section: Discussionsupporting
confidence: 84%
See 1 more Smart Citation
“…These decreases in Bunney-Hamburg psychosis ratings and the BPRS thinking disturbance score extend the previous findings of Pickar and colleagues that short term opioid system blockade decreases positive symp toms of psychosis (Pickar et al 1981a(Pickar et al , 1981b(Pickar et al , 1982c.…”
Section: Discussionsupporting
confidence: 84%
“…The results of treatment studies using naloxone have been incon clusive (see Bissette et al 1986;Pickar et al 1989). Opi ate antagonists were ineffective when used as the sole treatment for schizophrenia; however, when used as an adjuvant; brief trials of naloxone decreased positive symptoms of psychosis (Bissette et al 1986;Pickar et al 1981aPickar et al , 1981bPickar et al , 1982c. Unfortunately, the World Health Organization (WHO) international collaborative repeated-dose naloxone augmentation trial could not confIrm the results of these single-dose studies (Pickar et al 1989).…”
mentioning
confidence: 99%
“…On the whole, they were safe and well tolerated and resulted in significant improvements of various aspects of schizophrenic symtomatology such as positive and deficit symptoms, polydipsia, alcoholism, and tardive dyskinesia in some (Watson et al, 1978;Lehmann et al, 1979;Berger et al, 1981;Nishikawa et al, 1994a, b;Marchesi et al, 1995;Petrakis et al, 2004;Wonodi et al, 2004), but not all (Volavka et al, 1977;Pickar et al, 1982) participants.…”
Section: Opioid Antagonists May Improve Hedonic Deficits In Patients mentioning
confidence: 97%
“…Naltrexone and another opioid antagonist, naloxone, have either shown no worsening of the symptoms associated with schizophrenia or a modest therapeutic improvement in psychotic symptoms (Pickar et al 1982;Sernyak et al 1998). A few pilot studies have evaluated naltrexone in dually diagnosed patients.…”
Section: Introductionmentioning
confidence: 99%