Short Term, Oral Supplementation with Optimized Curcumin Does Not Impair Performance Improvements Associated with High Intensity Interval Training

Kisiolek, Jacob N.; Kheredia, Nikeeta; Flores, Victoria; Ramani, Arjun; Lisano, Jonathon; Johnston, Nora; Stewart, Laura K.

doi:10.1080/19390211.2021.1936335

Cited by 5 publications

(5 citation statements)

References 28 publications

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“…Ten papers displayed an overall low risk of bias ( Amalraj et al, 2020 ; Basham et al, 2019 ; Cardaci et al, 2020 ; Faria et al, 2020 ; Hillman et al, 2021 ; Kisiolek et al, 2021 ; Mallard et al, 2020 ; Nicol et al, 2015 ; Salehi et al, 2021; Sciberras et al, 2015 ).…”

Section: Resultsmentioning

confidence: 99%

“…I 2 statistics were as follows: 37.15% (0 h), 68.94% (24 h), 41.93% (48 h) and 20.32% (72 h). One study by Kisiolek et al (2021) was removed from this analysis due to reporting data in relation to supplement ingestion and time trial performance, and post-exercise intervals. One paper was removed (Salehi et al, 2021) as inflammation was assessed using CRP, along with a lack of specific time points post-exercise being reported.…”

Section: Resultsmentioning

confidence: 99%

“…Lastly this review investigated curcumin and inflammation. Previous research in this area has observed mixed results, with some authors reporting non-significant IL-6 reductions (McFarlin et al, 2016;Sciberras et al, 2015), no change (Faria et al, 2020;Kisiolek et al, 2021) or significant IL-6 increases (Mallard et al, 2020). One previous systematic review reported mostly non-significant effects (Suhett et al, 2020).…”

Section: Inflammationmentioning

confidence: 97%

“…Sixteen studies were assessed for bias, with six displaying some overall risk (Figure 2). Ten papers displayed an overall low risk of bias (Amalraj et al, 2020;Basham et al, 2019;Cardaci et al, 2020;Faria et al, 2020;Hillman et al, 2021;Kisiolek et al, 2021;Mallard et al, 2020;Nicol et al, 2015;Salehi et al, 2021;Sciberras et al, 2015). Risk of bias across studies.…”

Section: Risk Of Biasmentioning

confidence: 99%

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The effect of curcumin supplementation on functional strength outcomes and markers of exercise-induced muscle damage: A systematic review and meta-analysis

Oxley,

Peart

2023

Nutr Health

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Background: Curcumin is a polyphenol derived from the Curcuma longa L (turmeric) plant and has gained attention through its perceived anti-inflammatory characteristics. The potential interaction with exercise-induced muscle damage (EIMD) and delayed onset muscle soreness (DOMS) has led to investigation of curcumin as a post-exercise strategy that may have the potential to lessen acute reductions in functional strength (FS) following physical activity. Aim: The purpose of this review is to assess the evidence examining curcumin in relation to four outcome measures: FS, EIMD, DOMS and inflammation. Methods: A Medline, SPORTDiscus and CINAHL database search was undertaken with no publication date limit. Sixteen papers met the inclusion criteria and were included in this review. Three meta-analyses were completed for EIMD, DOMS and inflammation, respectively, with FS being excluded due to limited research. Results: Effect sizes were as follows: EIMD (0.15, −0.12, −0.04, −0.2 and −0.61 corresponding to 0, 24, 48, 72 and 96 h post-exercise, respectively), DOMS (−0.64, −0.33, 0.06, −0.53 and −1.16 corresponding to 0, 24, 48, 72 and 96 h post-exercise, respectively) and inflammation (−0.10, 0.26, 0.15 and 0.26 corresponding to 0, 24, 48 and 72 h post-exercise, respectively). A 96 h post-exercise inflammation meta-analysis was not conducted due to limited data. Conclusion: No effect sizes were statistically significant for EIMD ( p = 0.644, 0.739, 0.893, 0.601 and 0.134), DOMS ( p = 0.054, 0.092, 0.908, 0.119 and 0.074) and inflammation ( p = 0.729, 0.603, 0.611 and 0.396). Further research is needed to thoroughly examine whether an effect exists.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Inflammationmentioning

confidence: 97%

Section: Risk Of Biasmentioning

confidence: 99%

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The effect of curcumin supplementation on functional strength outcomes and markers of exercise-induced muscle damage: A systematic review and meta-analysis

Oxley,

Peart

2023

Nutr Health

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“…It also inhibits COX-2 and NF-kB signaling pathways while enhancing adaptability to training [ 7 ], offering similar benefits to NSAIDs without their side effects [ 8 ]. Its effectiveness in alleviating post-exercise inflammation has contributed to its growing popularity [ 9 ], though its exact mechanism of action remains unclear. A meta-analysis of studies in this field is necessary to derive more precise and reliable conclusions, ultimately providing a scientific basis for protecting athletes’ health.…”

Section: Introductionmentioning

confidence: 99%

Meta-analysis of the effect of curcumin supplementation on skeletal muscle damage status

Liu,

Lin,

2024

PLoS ONE

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Objectives Meta-analysis was conducted to examine the effect of supplemental curcumin intake on skeletal muscle injury status and to propose an optimal intervention program. Methods In accordance with the procedures specified in the PRISMA statement for systematic reviews and meta-analyses of randomized controlled trials, the Review Manager 5.3 was used to analyze the results of creatine kinase (CK), muscle soreness, interleukin-6 (IL-6), and range of motion (ROM) as outcome indicators in the 349 subjects included in the 14 articles. Results The effect size of curcumin supplementation on muscle soreness, mean difference (MD) = -0.61; the relationship between curcumin supplementation and muscle soreness for time of measurement (I2 = 83.6%)、the relationship between curcumin supplementation and muscle soreness for period of intervention (I2 = 26.2%)、the relationship between whether one had been trained (I2 = 0%) and supplementation dose (I2 = 0%) were not heterogeneous for the relationship between curcumin supplementation and muscle soreness; The effect size on CK, MD = -137.32; the relationship between curcumin supplementation and CK (I2 = 79.7%)、intervention period (I2 = 91.9%)、whether or not trained (I2 = 90.7%)、and no heterogeneity in the relationship between curcumin supplementation and CK for the time of measurement (I2 = 0%); The effect size MD = 4.10 for the effect on ROM; The effect size for IL-6 was MD = -0.33. Conclusions This meta-analysis highlights that curcumin supplementation significantly mitigates skeletal muscle damage, with notable improvements in CK levels, muscle soreness, IL-6 levels, and ROM. The results highlight the importance of curcumin dosage and timing, revealing that prolonged supplementation yields the best results, especially for untrained individuals or those less exposed to muscle-damaging exercise. For muscle soreness and ROM enhancement, a pre-emptive, low-dose regimen is beneficial, while immediate post-exercise supplementation is most effective at reducing CK and IL-6 levels.

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Curcumin/turmeric supplementation could improve blood pressure and endothelial function: A grade-assessed systematic review and dose–response meta-analysis of randomized controlled trials

Dehzad,

Ghalandari,

Askarpour

2024

Clinical Nutrition ESPEN

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Short Term, Oral Supplementation with Optimized Curcumin Does Not Impair Performance Improvements Associated with High Intensity Interval Training

Cited by 5 publications

References 28 publications

The effect of curcumin supplementation on functional strength outcomes and markers of exercise-induced muscle damage: A systematic review and meta-analysis

The effect of curcumin supplementation on functional strength outcomes and markers of exercise-induced muscle damage: A systematic review and meta-analysis

Meta-analysis of the effect of curcumin supplementation on skeletal muscle damage status

Curcumin/turmeric supplementation could improve blood pressure and endothelial function: A grade-assessed systematic review and dose–response meta-analysis of randomized controlled trials

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