Short-term outcomes following amniotic membrane and conventional dressing in skin graft donor site; a randomized clinical trial

Kazemzadeh, Jafar; Soleimani, Houshang

doi:10.34172/ipp.2022.29314

Cited by 2 publications

(1 citation statement)

References 13 publications

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“…As a result, the patients' comfort during therapeutic interventions could be one of the most indicators of using the HAM dressing. Numerous studies have reported amniotic membrane dressing reduces the pain severity in burn patients, and consequently, a reduction in analgesia administration [23,60,73,74]. According to Insausti et al, HAM does not induce the tumorigenic effects and cell contact growth inhibition.…”

Section: Discussionmentioning

confidence: 99%

Human amniotic membrane vs. silver sulfadiazine dressing in second-degree burns: a randomized controlled clinical trial

Moghimi,

Salehiyan,

Abdi

et al. 2023

Preprint

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Background Burn wounds require optimal medical management due to associated psycho-emotional and socioeconomic impacts, and severe pain. Utilizing synthetic and biological dressings improves healing and reduces burn wound complications. The present study aimed to compare the outcomes of using a human amniotic membrane (HAM) and conventional silver sulfadiazine (SSDZ) ointment as the dressings, in the management of the second-degree burn wound,2018, Zanjan, Iran. Methods Fifty patients participated in this clinical trial and were divided into two groups by simple randomization. The target group (n = 25) was treated with HAM, and the control group (n = 25) was treated with the SSDZ ointment. The researcher-designed checklist was used to determine the clinical performance in the follow-up assessments on days 7, 14, and 30. Results No significant difference was found in terms of gender, age, and the percentage of the burn wound (P > 0.05). Wound epithelialization (days 7,14, and 30), scar and pigmentation of the wound, pain severity, the amount of analgesia required, and the hospital stay length (on day 30) were significantly less in the target group, compared to the control (P < 0.05). Nonetheless, the treatment costs in the target group (170$) were significantly higher than in the control (71$) (P < 0.001). Conclusion The HAM as a technology-based therapy dressing, albeit expensive, is superior to the SSDZ ointment dressing in terms of wound healing and pain mitigation. Due to the efficiency of this novel product educational policies are recommended to implement technological therapy modules in the medical education curriculum.

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Section: Discussionmentioning

confidence: 99%

Human amniotic membrane vs. silver sulfadiazine dressing in second-degree burns: a randomized controlled clinical trial

Moghimi,

Salehiyan,

Abdi

et al. 2023

Preprint

View full text Add to dashboard Cite

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The impact of an open-label design on human amniotic membranes vs. silver sulfadiazine dressings for second-degree burns: a randomized controlled clinical trial

Moghimi,

Salehian,

Abdi

et al. 2024

BMC Surg

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Background Burn wounds require optimal medical management due to associated psycho-emotional and socioeconomic impacts and severe pain. The use of synthetic and biological dressings improves healing and reduces burn wound complications. The present study aimed to compare the outcomes of using human amniotic membrane (hAM) dressings and conventional silver sulfadiazine (SSDZ) ointment dressings in the management of second-degree burn wounds. Methods Fifty patients who participated in this clinical trial were divided into two groups via simple randomization. All the enrolled patients, who had burnt in the last 24 h, had thermal damage mechanisms and were suffering from less than 20% second-degree heat-burn wounds on the skin surface. The target group ( n = 25) was treated with hAM, and the control group ( n = 25) was treated with SSDZ ointment. The researcher-designed checklist was used to determine the clinical performance in the follow-up assessments on days 7, 14, and 30. Results No significant differences were detected in terms of sex, age, or percentage of burn wounds ( p > 0.05). Wound epithelialization at days 7, 14, and 30, scar formation, wound pigmentation, pain severity, analgesia requirements, and hospital stay length (on day 30) were significantly lower in the target group (treated with hAM) than in the control group (treated with SSDZ ointment) ( p < 0.05). However, treatment costs in the target group ($170) were significantly higher than those in the control group ($71) ( p < 0.001). Conclusion Despite its higher cost, hAM, as a technology-based therapy dressing, demonstrates superiority over SSDZ ointment in terms of wound healing and pain management.

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Short-term outcomes following amniotic membrane and conventional dressing in skin graft donor site; a randomized clinical trial

Cited by 2 publications

References 13 publications

Human amniotic membrane vs. silver sulfadiazine dressing in second-degree burns: a randomized controlled clinical trial

Human amniotic membrane vs. silver sulfadiazine dressing in second-degree burns: a randomized controlled clinical trial

The impact of an open-label design on human amniotic membranes vs. silver sulfadiazine dressings for second-degree burns: a randomized controlled clinical trial

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