“…Mirogabalin (MGB, DS-5565, Tarlige ® , (1R,5S,6S)-6-(aminomethyl)-3-ethyl-bicyclo [3.2.0]hept-3-ene-6-acetic acid), an orally administered gabapentinoid, is a novel, preferentially selective ligand for the α 2 δ-1 subunit of voltage-gated Ca 2+ (Ca V ) channels, and has been used in trials for investigations in the treatment of post-herpetic neuralgia, pain associated with fibromyalgia, and diabetic peripheral neuropathic pain [ 1 , 2 , 3 , 4 , 5 , 6 , 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 ]. Owing to the considerable research effort, this compound is being investigated for the treatment of peripheral neuropathic pain and fibromyalgia and has demonstrated promising results in patients with diabetic peripheral neuropathy [ 2 , 3 , 4 , 5 , 6 , 9 , 11 , 14 , 15 ]. Moreover, it has recently been shown to be effective in alleviating anxiety, and in improving cognitive impairments in rats injected repeatedly and intramuscularly with acidic saline [ 12 , 13 , 17 ].…”