Short‐term physiological response to high‐frequency‐actuated pVAD support

Rebholz, Mathias; Dual, Seraina A.; Batliner, Martin; Meboldt, Mirko; Daners, Marianne Schmid

doi:10.1111/aor.13521

Cited by 5 publications

(8 citation statements)

References 42 publications

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“…For the high‐speed measurements (dynamic measurements) the same two strain sensors were used and the heart phantom connected to a custom‐built bellows actuator. [ 49,50 ] The actuator was comprised of a polytetrafluorethylene (PTFE) bellows (ElringKlinger AG, Dettingen/Erms, Germany) that could be compressed/stretched through a voice coil (Moticont, Van Nuys, CA, USA) in order to provide a volume displacement (of up to 65 mL). The actuator and, hence, the bellows were driven by a sinusoidal reference signal, allowing the implementation of volume changes (between 10 and 30 mL), as well as, a range of physiological heart rates (60, 80, and 100 bpm).…”

Section: Methodsmentioning

confidence: 99%

Continuous Heart Volume Monitoring by Fully Implantable Soft Strain Sensor

Dual

Zambrano

Sündermann

et al. 2020

Adv Healthcare Materials

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Cardiothoracic open-heart surgery has revolutionized the treatment of cardiovascular disease, the leading cause of death worldwide. After the surgery, hemodynamic and volume management can be complicated, for example in case of vasoplegia after endocarditis. Timely treatment is crucial for outcomes. Currently, treatment decisions are made based on heart volume, which needs to be measured manually by the clinician each time using ultrasound. Alternatively, implantable sensors offer a real-time window into the dynamic function of our body. Here it is shown that a soft flexible sensor, made with biocompatible materials, implanted on the surface of the heart, can provide continuous information of the heart volume after surgery. The sensor works robustly for a period of two days on a tensile machine. The accuracy of measuring heart volume is improved compared to the clinical gold standard in vivo, with an error of 7.1 mL for the strain sensor versus impedance and 14.0 mL versus ultrasound. Implanting such a sensor would provide essential, continuous information on heart volume in the critical time following the surgery, allowing early identification of complications, facilitating treatment, and hence potentially improving patient outcome.

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Section: Methodsmentioning

confidence: 99%

Continuous Heart Volume Monitoring by Fully Implantable Soft Strain Sensor

Dual

Zambrano

Sündermann

et al. 2020

Adv Healthcare Materials

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“…Two separate studies have investigated pulsatile VADs operated at frequencies that exceed the heart rate. 29,30 The in silico and in vitro results demonstrated that pulsatility remains sufficiently high despite the high frequency of operation. In all, the present work is a unique example of a converging approach in which engineering and biological requirements are considered together during the design phase.…”

Section: The Hyperelastic Membrane Design and Validationmentioning

confidence: 98%

A Novel Hybrid Membrane VAD as First Step Toward Hemocompatible Blood Propulsion

et al. 2020

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Heart failure is a raising cause of mortality. Heart transplantation and ventricular assist device (VAD) support represent the only available lifelines for end stage disease. In the context of donor organ shortage, the future role of VAD as destination therapy is emerging. Yet, major drawbacks are connected to the long-term implantation of current devices. Poor VAD hemocompatibility exposes the patient to life-threatening events, including haemorrhagic syndromes and thrombosis. Here, we introduce a new concept of artificial support, the Hybrid Membrane VAD, as a first-of-its-kind pump prototype enabling physiological blood propulsion through the cyclic actuation of a hyperelastic membrane, enabling the protection from the thrombogenic interaction between blood and the implant materials. The centre of the luminal membrane surface displays a rationally-developed surface topography interfering with flow to support a living endothelium. The precast cell layer survives to a range of dynamically changing pump actuating conditions i.e., actuation frequency from 1 to 4 Hz, stroke volume from 12 to 30 mL, and support duration up to 313 min, which are tested both in vitro and in vivo, ensuring the full retention of tissue integrity and connectivity under challenging conditions. In summary, the presented results constitute a proof of principle for the Hybrid Membrane VAD concept and represent the basis for its future development towards clinical validation.

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“…Mathias Rebholz et al of ETH Zurich, Zurich, Switzerland presented data on their pulsatile ventricular assist device (pVAD) system consisting of a pump and an actuator specifically designed for actuation frequencies of up to 240 bpm. In vitro and in vivo results of the short‐term reaction of the cardiovascular system show no significant changes in left ventricular and aortic pressure between actuation frequencies from 60 to 240 bpm.…”

Section: Cardiac Support and Blood Pumpsmentioning

confidence: 99%

Artificial Organs 2019: A year in review

Malchesky¹

2020

Artificial Organs

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In this Editor’s Review, articles published in 2019 are organized by category and summarized. These provide a brief reflection of the research and progress in artificial organs intended to advance and better human life while providing insight for continued application of these technologies and methods. Artificial Organs continues in the original mission of its founders “to foster communications in the field of artificial organs on an international level.” Artificial Organs continues to publish developments and clinical applications of artificial organ technologies in this broad and expanding field of organ Replacement, Recovery, and Regeneration from all over the world. Peer‐reviewed Special Issues this year included contributions from the 14th International Conference on Pediatric Mechanical Circulatory Support Systems and Pediatric Cardiopulmonary Perfusion edited by Dr Akif Undar, and the 26th Congress of the International Society for Mechanical Circulatory Support edited by Dr Minoru Ono and Dr Francesco Moscato. Additionally, important editorials highlighted the need for sustainability in hemodialysis, challenges and opportunities in mechanical circulatory support, progress in artificial pancreas development, historical perspectives on ventilators and dialysis, tissue engineering for cardiac support, and regional updates from India and China. Our Pioneer Series continues to highlight the many researchers who created this field of study. This year we debuted a new series entitled “Recent Progress in Artificial Organs” prepared by Vakhtang Tchantchaleishvili and Elizabeth Maynes of Thomas Jefferson University, Philadelphia, PA, USA. This series highlights recent advances and new developments in the field. We take this time also to express our gratitude to our authors for contributing their work to this journal. We offer our very special thanks to our reviewers who give so generously of their time and expertise to review, critique, and especially provide meaningful suggestions to the author’s work. Without our dedicated expert reviewers, the quality expected from such a journal would not be possible. We also express our special thanks to our Publisher, John Wiley & Sons, for their expert attention and support in the production Artificial Organs. We look forward to reporting further advances in the coming years.

show abstract

Short‐term physiological response to high‐frequency‐actuated pVAD support

Cited by 5 publications

References 42 publications

Continuous Heart Volume Monitoring by Fully Implantable Soft Strain Sensor

Continuous Heart Volume Monitoring by Fully Implantable Soft Strain Sensor

A Novel Hybrid Membrane VAD as First Step Toward Hemocompatible Blood Propulsion

Artificial Organs 2019: A year in review

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