“…If some of the MUS turn out to have developmental origins, these drugs may be appropriate to consider for their therapeutic potential in these patients. This hypothesis also may explain the effectiveness of such ‘central’ approaches to therapy as tricyclic antidepressants (which among other actions attenuate catecholaminergic output) [75,76,77,78], hypnosis [79, 80], effective doctor–patient communication [81], use of psychiatrists as consultants in the general practice setting [82], and various other psychological approaches to treatment [2,83,84,85,86,87,88] that might reduce the perception of threat in amenable patients. We also have successfully used an ‘environmental’ approach to therapy for cats with FIC [89]; EMGEX is one candidate mechanism for the effects of environmental enrichment [90].…”