Short-term Regulation of Resistin in vivo by Oral Lipid Ingestion and in vitro by Fatty Acid Stimulation

Abstract

OLI is a physiological repressor of systemic resistin release whereas FFA upregulate resistin release in vitro from adipocytes.

Meteorin-Like Protein (Metrnl) in Obesity, during Weight Loss and in Adipocyte Differentiation

“…Palmitic acid (PA; 100 µM), stearic acid (StA; 100 µM), myristic acid (MyA; 100 µM), lauric acid (LaA; 100 µM), oleic acid (OA; 10 µM), linoleic acid (LiA; 10 µM), palmitoleic acid (PoA; 10 µM), arachidonic acid (ArA; 10 µM), eicosapentaenoic acid (EPA; 10 µM), and docosahexaenoic acid (DHA; 10 µM) were used for overnight (18 h) stimulation experiments ( n = 6 wells each). All stimulating doses had been determined by previous experiments in adipocyte culture with respect to dose effects and cell viability [ 35 ]. In addition, cells were incubated under low/high glucose (5.56 mM/25 mM) concentrations and under low/high (0.2 and 2.0 nM) insulin concentrations.…”

Intermittent Fasting in Cardiovascular Disorders—An Overview

“…Its concentration correlates with resistance to insulin and obesity. It has pro-inflammatory activity [53]. It also promotes the pro-inflammatory activity of neutrophils and macrophages as well as the formation of extracellular deposits in vessels.…”

CTRP‐3 is permeable to the blood–brain barrier and is not regulated by glucose or lipids in vivo

“…This study cohort was characterized and published earlier for common anthropometric and laboratory parameters as well as for lipidinduced postprandial regulation of several adipokines [24][25][26][27] and bile acids [28]. This study cohort was characterized and published earlier for common anthropometric and laboratory parameters as well as for lipidinduced postprandial regulation of several adipokines [24][25][26][27] and bile acids [28].…”

“…Study cohort 2: Oral lipid tolerance test. This study cohort was characterized and published earlier for common anthropometric and laboratory parameters as well as for lipidinduced postprandial regulation of several adipokines [24][25][26][27] and bile acids [28]. Hundred healthy volunteers (58 females and 42 males, 66 with normal weight and 34 overweight/obese) gave their informed consent to the study, and participants were examined at the University Hospital of Regensburg.…”

“…The study was approved by the local ethical committee. Detailed information concerning the study procedure can be referred from the literature [24][25][26][27] undergoing neurological evaluation at the Department of Neurology, University Hospital Giessen, Germany, were collected without prior selection. General patient characteristics have been published earlier by our group in two studies on the role of progranulin, resistin and adipsin in CSF [29,30].…”