Short‐term repeatability of the peguero‐lo presti electrocardiographic left ventricular hypertrophy criteria

Abstract

Background: Electrocardiographic left ventricular hypertrophy (ECG-LVH) represents preclinical cardiovascular disease and predicts cardiovascular disease morbidity and mortality. While the newly developed Peguero-Lo Presti ECG-LVH criteria have greater sensitivity for LVH than the Cornell voltage and Sokolow-Lyon criteria, its short-term repeatability is unknown. Therefore, we characterized the short-term repeatability of Peguero-Lo Presti ECG-LVH criteria and evaluate its agreement with Cornell voltage and Sokolow-Lyon ECG-LVH criteria.Methods: Participants underwent two resting, standard, 12-lead ECGs at each of two visits one week apart (n = 63). We defined a Peguero-Lo Presti index as a sum of the deepest S wave amplitude in any single lead and lead V 4 (i.e., S D + SV 4 ) and defined Peguero-Lo Presti LVH index as ≥ 2,300 µV among women and ≥ 2,800 µV among men. We estimated repeatability as an intraclass correlation coefficient (ICC), agreement as a prevalence-adjusted bias-adjusted kappa coefficient (κ), and precision using 95% confidence intervals (CIs). Results:The Peguero-Lo Presti index was repeatable: ICC (95% CI) = 0.94 (0.91-0.97).Within-visit agreement of Peguero-Lo Presti LVH was high at the first and second visits: κ (95% CI) = 0.97 (0.91-1.00) and 1.00 (1.00-1.00). Between-visit agreement of the first and second measurements at each visit was comparable: κ (95% CI) = 0.90 (0.80-1.00) and 0.93 (0.85-1.00). Agreement of Peguero-Lo Presti and Cornell or Sokolow-Lyon LVH on any one of the four ECGs was slightly lower: κ (95% CI) = 0.71 (0.54-0.89). Conclusion:The Peguero-Lo Presti index and LVH have excellent repeatability and agreement, which support their use in clinical and epidemiological studies.

Reproducibility of global electrical heterogeneity measurements on 12-lead ECG: The Multi-Ethnic Study of Atherosclerosis

“…In this large study of more than 4,000 MESA participants with two consecutive routine Only few and mostly small previous studies assessed the reproducibility of ECG biomarkers. [34][35][36][37][38][39] The earlier small (n=253) GEH reproducibility study included primarily African Americans, performed only N median beat analysis, and demonstrated similar findings to the current study. [25] In two random 10-second ECG segments selected in 5-minute ECG recording, a heart rate differed by ~5 bpm, and spatial QRS-T angle differed by ~13 degrees.…”

Reproducibility of global electrical heterogeneity measurements on 12-lead ECG: The Multi-Ethnic Study of Atherosclerosis

“…Only few and mostly small previous studies assessed the reproducibility of ECG biomarkers. [34][35][36][37][38][39] The earlier small (n=253) GEH reproducibility study included primarily African Americans, performed only N median beat analysis, and demonstrated similar findings to the current study. [25] In two random 10-second ECG segments selected in 5-minute ECG recording, a heart rate differed by ~5 bpm, and spatial QRS-T angle differed by ~13 degrees.…”