Short term resistance training enhanced plasma apoA-I and FABP4 levels in Streptozotocin-induced diabetic rats

Abstract

BackgroundType 1 diabetes mellitus is associated with a high risk for early atherosclerotic complications. Altered lipids and lipoprotein metabolism in chronic diabetes mellitus is associated with pathogenesis of atherosclerosis and other cardiovascular diseases. The aim of this study was to investigate the effects of 4 weeks resistance training on plasma lipid profile, fatty acid binding protein (FABP) 4 and apolipoprotein (apo) A-I levels in type 1 diabetic rats.MethodsThirty two male Wister rats (12–14 weeks old) were randomly divided into four groups: non-diabetic control; non-diabetic trained; diabetic control; diabetic trained. The rats in training groups were subjected to a resistance training program (3 days/wk, for 4 wk) consisted of climbing a ladder carrying a load suspended from the tail.ResultsDiabetic inducing increased plasma apoA-I and decreased FABP4 levels compared with non-diabetic control group (respectively, P = 0.001 & P = 0.041). After 4 weeks’ resistance training, plasma levels of apoA-I and FABP4 in the diabetic trained rats were significantly higher compared with the diabetic control group (respectively, P = 0.003 & P = 0.017). Plasma HDL-C level in diabetic trained group was higher than diabetic control group (P = 0.048). Liver triglycerides concentrations were significantly lower in both trained (non-diabetic and diabetic) groups compared with their control groups (respectively, P = 0.041 and P = 0.002).ConclusionThese data indicated that resistance training may be an efficient intervention strategy to increase plasma apoA-I, HDL-C and FABP4 concentrations, along with decreases liver triglycerides in streptozotocin induced diabetic rats. Further research is needed to elucidate physiological significance of circulating FABP4 levels.

Protective effect of alpha‐lipoic acid, aerobic or resistance exercise from colitis in second hand smoke exposed young rats

“…For resistance exercise training, the rats climbed to a vertical ladder (1.1 m high, 26 steps, 80° incline) 3 days per week with eight repeats and three sets for 5 weeks . All rats were adapted to climbing in the first week, for 3 days, before resistance exercise sessions.…”

“…For resistance exercise training, the rats climbed to a vertical ladder (1.1 m high, 26 steps, 80° incline) 3 days per week with eight repeats and three sets for 5 weeks. 40 All rats were adapted to climbing in the first week, for 3 days, before resistance exercise sessions. On the initial adaptation day, rats climbed the ladder without load and on the following exercise days the load was increased, respectively, to 50% and 75% of the body weight.…”

Resistance training alone or combined with leucine supplementation improves the serum lipid profile of diabetic rats, whereas leucine alone does not

“…In addition, the resistance training has also been considered as a potent non-pharmacological tool. In STZ-induced diabetic rats, resistance training increased muscle strength, interleukin-15 (IL-15) secretion capacity as a myokine that is not depressed in the diabetic state and improved adiposity and obesityassociated inflammation and the serum lipid profile (Molanouri et al 2014;Safarzade and Talebi-Garakani 2014). Number of studies regarding the effects of resistance training on lipoproteins metabolism in diabetes is very limited and their findings are still controversial.…”

“…Number of studies regarding the effects of resistance training on lipoproteins metabolism in diabetes is very limited and their findings are still controversial. Research show that resistance training associated with aerobic training increases high-density lipoprotein cholesterol (HDL-C) and reduces LDL-C (Safarzade and Talebi-Garakani 2014). Furthermore, studies in humans show that resistance training alone reduces or does not alter the concentrations of LDL-C in blood (Cauza et al 2005;Ghanbari -Niaki et al 2011) and decreases or increases circulating HDL-C (Costa et al 2011;Williams et al 2011).…”

Interval Training Is Insufficient to Attenuate Metabolic Disturbances in Diabetic Rats

“…This metabolic disease is associated with hyperglycemia, which leads to many alterations lipids and lipoprotein metabolism, increasing risk of atherosclerosis and other cardiovascular diseases 2 . Nevertheless, T1D has been associated with various defects in the innate immune system, which in turn may increase the risk of infections 3 .…”