Short-term social isolation induces depressive-like behaviour and reinstates the retrieval of an aversive task: Mood-congruent memory in male mice?

Takatsu-Coleman, André L.

doi:10.1503/jpn.120050

Cited by 52 publications

(34 citation statements)

References 57 publications

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“…). There is a general lack of agreement over whether acute isolation alters immobility in these assays in mice . However, more consistent results have been obtained in monogamous prairie voles, wherein females or males isolated from their bonded partner for 3–5 days show an increase in immobility time …”

Section: Homeostatic Response To Social Deficit: a Self‐protective Comentioning

confidence: 97%

Neural mechanisms of social homeostasis

Matthews

Tye

2019

Annals of the New York Academy of Sciences

154

101

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Social connections are vital to survival throughout the animal kingdom and are dynamic across the life span. There are debilitating consequences of social isolation and loneliness, and social support is increasingly a primary consideration in health care, disease prevention, and recovery. Considering social connection as an “innate need,” it is hypothesized that evolutionarily conserved neural systems underlie the maintenance of social connections: alerting the individual to their absence and coordinating effector mechanisms to restore social contact. This is reminiscent of a homeostatic system designed to maintain social connection. Here, we explore the identity of neural systems regulating “social homeostasis.” We review findings from rodent studies evaluating the rapid response to social deficit (in the form of acute social isolation) and propose that parallel, overlapping circuits are engaged to adapt to the vulnerabilities of isolation and restore social connection. By considering the neural systems regulating other homeostatic needs, such as energy and fluid balance, we discuss the potential attributes of social homeostatic circuitry. We reason that uncovering the identity of these circuits/mechanisms will facilitate our understanding of how loneliness perpetuates long‐term disease states, which we speculate may result from sustained recruitment of social homeostatic circuits.

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Section: Homeostatic Response To Social Deficit: a Self‐protective Comentioning

confidence: 97%

Neural mechanisms of social homeostasis

Matthews

Tye

2019

Annals of the New York Academy of Sciences

154

101

View full text Add to dashboard Cite

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“…Indeed, many studies have shown that maternal separation (isolating pups from dam) and neonatal isolation (isolating pups from dam and other pups) are significant stressors, evoking ultrasonic vocalizations and inducing CORT release in pups (Hennessy and Weinberg, 1990; Kehne et al, 1991; Kuhn et al, 1990; Levine et al, 1991; McCormick et al, 1998; Viau et al, 1996). In addition, acute isolation of group-housed rats also induces CORT, which is taken as a clear indication of stress (Takatsu-Coleman et al, 2013). Many researchers thus make the leap of considering isolation rearing a condition of chronic stress, citing large CORT induction from acute stress as evidence.…”

Section: 1 What Is the Best Control For Enrichment?mentioning

confidence: 99%

Inoculation stress hypothesis of environmental enrichment

Crofton

Zhang

Green

2015

Neuroscience & Biobehavioral Reviews

176

112

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One hallmark of psychiatric conditions is the vast continuum of individual differences in susceptibility vs. resilience resulting from the interaction of genetic and environmental factors. The environmental enrichment paradigm is an animal model that is useful for studying a range of psychiatric conditions, including protective phenotypes in addiction and depression models. The major question is how environmental enrichment, a non-drug and non-surgical manipulation, can produce such robust individual differences in such a wide range of behaviors. This paper draws from a variety of published sources to outline a coherent hypothesis of inoculation stress as a factor producing the protective enrichment phenotypes. The basic tenet suggests that chronic mild stress from living in a complex environment and interacting non-aggressively with conspecifics can inoculate enriched rats against subsequent stressors and/or drugs of abuse. This paper reviews the enrichment phenotypes, mulls the fundamental nature of environmental enrichment vs. isolation, discusses the most appropriate control for environmental enrichment, and challenges the idea that cortisol/corticosterone equals stress. The intent of the inoculation stress hypothesis of environmental enrichment is to provide a scaffold with which to build testable hypotheses for the elucidation of the molecular mechanisms underlying these protective phenotypes and thus provide new therapeutic targets to treat psychiatric/neurological conditions.

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“…Short term SI induces depressive symptoms in male mice [122] and this appears to be exacerbated in animals subjected to injury. In an experimental stroke model, Verma et al [130] showed that SI was associated with post-stroke development of several distinct phenotypes associated with depression: avolition, anhedonia, and sociability.…”

Section: Part I: Si and Its Effects On All-cause Mortalitymentioning

confidence: 99%

One is the deadliest number: the detrimental effects of social isolation on cerebrovascular diseases and cognition

2014

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The deleterious effects of chronic social isolation (SI) have been recognized for several decades. Isolation is a major source of psychosocial stress and is associated with an increased prevalence of vascular and neurological diseases. In addition, isolation exacerbates morbidity and mortality following acute injuries such as stroke or myocardial infarction. In contrast, affiliative social interactions can improve organismal function and health. The molecular mechanisms underlying these effects are unknown. Recently, results from large epidemiological trials and pre-clinical studies have revealed several potential mediators of the detrimental effects of isolation. At least three major biological systems have been implicated; the neuroendocrine (HPA) axis, the immune system, and the autonomic nervous system. This review summarizes studies examining the relationship between isolation and mortality and the pathophysiological mechanisms underlying SI. Cardiovascular, cerebrovascular, and neurological diseases including atherosclerosis, myocardial infarction, ischemic stroke and Alzheimer’s disease are given special emphasis in the context of SI. Sex differences are highlighted and studies are separated into clinical and basic science for clarity.

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Short-term social isolation induces depressive-like behaviour and reinstates the retrieval of an aversive task: Mood-congruent memory in male mice?

Cited by 52 publications

References 57 publications

Neural mechanisms of social homeostasis

Neural mechanisms of social homeostasis

Inoculation stress hypothesis of environmental enrichment

One is the deadliest number: the detrimental effects of social isolation on cerebrovascular diseases and cognition

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