Short-term stent strut coverage: optical coherence tomography vs high-definition intravascular ultrasound

Dobrolińska, Magdalena; Gąsior, Paweł; Roleder, Tomasz; Ochała, Andrzej; Wojakowski, Wojciech

doi:10.33963/kp.a2021.0026

Cited by 2 publications

(1 citation statement)

References 10 publications

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“…This modality is characterized by a high resolution (15–20 µm axial and 20–40 µm lateral). Therefore, OCT enables precise quantification and detection of tissue coverage, which might be missed by other imaging modalities, even by high-definition intravascular ultrasound (HD-IVUS) [ 22 , 23 , 24 ] ( Figure 1 ). Several preclinical studies have investigated the accuracy of OCT and proven its reliability.…”

Section: Neointimal Coverage Assessed By Octmentioning

confidence: 99%

Importance of Short-Term Neointimal Coverage of Drug-Eluting Stents in the Duration of Dual Antiplatelet Therapy

Fluder-Wlodarczyk,

Pawłowski,

Chuchra

et al. 2024

JCM

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Dual antiplatelet therapy (DAPT) is mandatory after percutaneous coronary intervention (PCI) with drug-eluting stent (DES) implantation, but optimal DAPT duration remains a topic of intense discussion. The shorter regimen of DAPT might be especially beneficial for high-bleeding-risk (HBR) patients. Novel stent platforms have been designed with innovations that should facilitate vessel healing following stent implantation and enable short DAPT. This review aimed to summarize evidence of the neointimal coverage of short-term stents and their implications for DAPT duration. Results from histological and optical coherence tomography (OCT) studies confirm the significant role of uncovered struts after the implantation of a stent in patients presenting with late stent thrombosis. Several studies have shown favorable vessel healing at one month (with 83.2% of covered struts, on average) and three months following stent implantation (with 93.3% of covered struts, on average). Solely HBR patient trials have proven that one month of DAPT can be applicable and safe in this population. Three-month DAPT was tested in a more diverse population and remains effective and safe in comparison to a longer DAPT regimen. That evidence proves that short-term DAPT might be applicable, especially for HBR patients.

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Section: Neointimal Coverage Assessed By Octmentioning

confidence: 99%

Importance of Short-Term Neointimal Coverage of Drug-Eluting Stents in the Duration of Dual Antiplatelet Therapy

Fluder-Wlodarczyk,

Pawłowski,

Chuchra

et al. 2024

JCM

Self Cite

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Assessment of Effectiveness of the Algorithm for Automated Quantitative Analysis of Metallic Strut Tissue Short-Term Coverage with Intravascular Optical Coherence Tomography

Fluder-Wlodarczyk,

Schneider,

Pawłowski

et al. 2024

JCM

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Background: Due to its high resolution, optical coherence tomography (OCT) is the most suitable modality for neointimal coverage assessments. Evaluation of stent healing seems crucial to accurately define their safety profile since delayed healing is connected with stent thrombosis. This study aimed to present an algorithm for automated quantitative analysis of stent strut coverage at the early stages of vessel healing in intravascular OCT. Methods: A set of 592 OCT frames from 24 patients one month following drug-eluting stent implantation was used to assess the algorithm’s effectiveness. Struts not covered on any side or covered but only on one side were categorized as uncovered. The algorithm consists of several key steps: preprocessing, vessel lumen segmentation, automatic strut detection, and measurement of neointimal thickness. Results: The proposed algorithm proved its efficiency in lumen and stent area estimation versus manual reference. It showed a high positive predictive value (PPV) (89.7%) and true positive rate (TPR) (91.4%) in detecting struts. A qualitative assessment for covered and uncovered struts was characterized by high TPR (99.1% and 80%, respectively, for uncovered and covered struts) and PPV (77.3% and 87%). Conclusions: The proposed algorithm demonstrated good agreement with manual measurements. Automating the stent coverage assessment might facilitate imaging analysis, which might be beneficial in experimental and clinical settings.

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Short-term stent strut coverage: optical coherence tomography vs high-definition intravascular ultrasound

Cited by 2 publications

References 10 publications

Importance of Short-Term Neointimal Coverage of Drug-Eluting Stents in the Duration of Dual Antiplatelet Therapy

Importance of Short-Term Neointimal Coverage of Drug-Eluting Stents in the Duration of Dual Antiplatelet Therapy

Assessment of Effectiveness of the Algorithm for Automated Quantitative Analysis of Metallic Strut Tissue Short-Term Coverage with Intravascular Optical Coherence Tomography

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