Short term toxicity study in rats dosed with pulegone and menthol

Thorup, Inger; Würtzen, G.; Carstensen, John; Olsen, P.

doi:10.1016/0378-4274(83)90120-0

Cited by 101 publications

(49 citation statements)

References 7 publications

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“…Since peppermint oil contains 1-3% pulegone, which is known to be toxic, a comparison of the toxicology of menthol with pulegone was undertaken in order to determine if menthol could also be implicated as a cause of neuropathy. Rats were given menthol by gavage for 28 days at 0, 200, 400 and 800mgkg-' and showed few toxic effects (Thorup et al 1983b). For menthol, the only effects were an increase in liver weight and increased vacuolization of hepatocytes which was evident at all doses, and probably represents an induction of liver enzymes.…”

Section: Toxicologymentioning

confidence: 99%

Menthol and Related Cooling Compounds

Eccles

1994

Journal of Pharmacy and Pharmacology

423

334

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ToxicologySummary-Menthol and related cooling compounds such as 'coolant agent lo', are widely used in products ranging from common cold medications to toothpastes, confectionery, cosmetics and pesticides. The review brings together a range of information on production and chemistry of menthol, and its metabolism, mechanism of action, structure-activity relationships, pharmacology and toxicology. In particular, the coolant action and carminative actions of menthol are discussed in terms of actions on calcium conductance in sensory nerves and smooth muscle. The actions of menthol on the nose, respiratory reflexes, oral cavity, skin and gastrointestinal tract are reviewed.

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Section: Toxicologymentioning

confidence: 99%

Menthol and Related Cooling Compounds

Eccles

1994

Journal of Pharmacy and Pharmacology

423

334

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“…It is used in flavoring agents, in perfumery, and in aromatherapy. It was reported that the chemical is toxic to rats if a large quantity is consumed [22]. Pulegone is also an insecticide the most powerful of three insecticides naturally occurring in many mint species [23].…”

Section: Resultsmentioning

confidence: 99%

Antimicrobial Effect of Essential Oil of Ziziphora tenuior on Water by Heterotrophic Plate Counts Method in Kerman (Southeast of Iran)

Ganjali¹,

Harati²,

Kaykhaii³

2016

IJCEA

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Abstract-The increasing demands of consumers for using less chemical preservatives has led to increasing number of researches to produce natural compounds with antimicrobial properties. Fresh aerial parts of wild Ziziphora tenuior were collected in Eastern Iran. Z.tenuior samples were collected after initial preparation isolated from the aboveground plant parts and plant samples preparation by water distillation using Clevenger apparatus after determining the optimal conditions for making essential oil was obtained. Essential oil with an efficiency of 1/1 percent (g/g) was obtained and by GC-MS to determine the composition of the essential oils was analyzed and indicates 21 compounds. Key combinations were as: pulegone (82.6 %) and limonene (6.8%) which was extracted. the studied essential oil would exhibit good antimicrobial properties, this essential oil in 0.08 ml concentration could eliminate microorganisms in water. but this was not evaluated and further investigation should be carried out for use of this essential oil in various industries.Index Terms-Ziziphora tenuior, antimicrobial, essential oil, GC-MS, heterotrophic plate counts method.

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“…In a 28-day oral gavage study in rats, pulegone was administered at doses of 0 20, 60 and 160 mg/kg/day. The NOEL for pulegone was 20 mg/kg/day (Thorup et al 1983). In experimental animals, pulegone is metabolically transformed (CYP450 involvement) to methofuran and other metabolites.…”

Section: Toxicology Summary and Data Analysismentioning

confidence: 99%

Proposed Occupational Exposure Limits for Non-Carcinogenic Hanford Waste Tank Vapor Chemicals

Poet¹,

Timchalk²

2006

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Short term toxicity study in rats dosed with pulegone and menthol

Cited by 101 publications

References 7 publications

Menthol and Related Cooling Compounds

Menthol and Related Cooling Compounds

Antimicrobial Effect of Essential Oil of Ziziphora tenuior on Water by Heterotrophic Plate Counts Method in Kerman (Southeast of Iran)

Proposed Occupational Exposure Limits for Non-Carcinogenic Hanford Waste Tank Vapor Chemicals

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