Short-term Toxicological Evaluation of Monodora myristica Seed Oil

Ajayi, I. A.

doi:10.9790/2402-0355358

Cited by 1 publication

(2 citation statements)

References 23 publications

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“…Instructively, these signs were absent in group 1 and group 2 of Phase I (Hodge and Sterner, 1943;Loomis and Hayes, 1996;Letsara et al, 2020). In contrast to this study, however, several authors have reported different parts of M. myristica, extracted with different solvents, to be very safe Isiogugu et al, 2018;Ajayi et al, 2013).…”

Section: Acute Toxicity Studycontrasting

confidence: 59%

“…Isiogugu et al, (2018), who worked on the root bark, reported LD50 value above 5000 mg/kg. Ajayi et al, (2013), investigated the short-term toxicological effects of the seed oil of M. myristica, and concluded that there were no toxic effects on albino rats. who evaluated the acute and sub-lethal toxicological profile of the ethyl acetate fraction of the seed extract, also reported LD50 greater than 5000 mg/kg.…”

Section: Introductionmentioning

confidence: 99%

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Acute toxicity studies, physicochemical and GC/MS analyses of Monodora myristica (Gaertn.) Dunal oil

Miediegha¹,

Owaba²,

Okori-West³

2023

njpr

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Background: The seeds of Monodora myristica, a tropical plant belonging to the family Annonaceae, are widely used as condiments in the preparation of a number of African delicacies, to impart or enhance flavour. Their use is largely due to the volatile and fixed oils contained in the nuts.Objective: To screen for the acute toxicity (LD50) profile, determine the physicochemical properties, as well as carry out GC-MS analysis of the seed oil of Monodora myristica.Method: The acute toxicity screening was done using Lorke’s method. Physicochemical profile of the oil was determined using standard methods. GC-MS analysis of the oil sample was also carried out, using Shimadzu GCMS-QP2010SE.Results: The acute toxicity study showed that the oil sample had an LD50 of 316 mg/kg. The acid value was determined to be 9.27 mg KOH/g oil, while saponification value was 194.95 mg KOH/g oil. GC-MS analysis of the oil revealed that it contained fatty acids such as n-hexadecanoic acid, cis-vaccenic acid and 9,12-octadecadienoic acid; as well as terpinoids such as alpha-terpineol and alpha-cadinol.Conclusion: Results of the toxicological screening indicates that Monodora myristica oil is moderately toxic as the LD50 was within 50 – 500 mg/kg range. The oil has a relatively high tendency to go rancid due to the high acid value of 9.27 mg KOH/g oil.

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