Short term transcriptional responses of P450s to phytochemicals in insects and mites

Vandenhole, Marilou; Dermauw, Wannes; Leeuwen, Thomas Van

doi:10.1016/j.cois.2020.12.002

Cited by 52 publications

(31 citation statements)

References 78 publications

(62 reference statements)

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“…P450 genes may also be induced upon exposure to a xenobiotic (19,33,60,62,109). However, while induced tolerance to plant allelochemicals is common (109), a similar protection afforded by exposure to a pesticide is not.…”

Section: P450 Inductionmentioning

confidence: 99%

The Role of Cytochrome P450s in Insect Toxicology and Resistance

Nauen

Bass

Feyereisen

et al. 2022

Annu. Rev. Entomol.

244

130

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Insect cytochrome P450 monooxygenases (P450s) perform a variety of important physiological functions, but it is their role in the detoxification of xenobiotics, such as natural and synthetic insecticides, that is the topic of this review. Recent advances in insect genomics and postgenomic functional approaches have provided an unprecedented opportunity to understand the evolution of insect P450s and their role in insect toxicology. These approaches have also been harnessed to provide new insights into the genomic alterations that lead to insecticide resistance, the mechanisms by which P450s are regulated, and the functional determinants of P450-mediated insecticide resistance. In parallel, an emerging body of work on the role of P450s in defining the sensitivity of beneficial insects to insecticides has been developed. The knowledge gained from these studies has applications for the management of P450-mediated resistance in insect pests and can be leveraged to safeguard the health of important beneficial insects. Expected final online publication date for the Annual Review of Entomology, Volume 67 is January 2022. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.

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Section: P450 Inductionmentioning

confidence: 99%

The Role of Cytochrome P450s in Insect Toxicology and Resistance

Nauen

Bass

Feyereisen

et al. 2022

Annu. Rev. Entomol.

244

130

View full text Add to dashboard Cite

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“…The detoxification genes are induced after exposure to phytochemicals or even constitutively overexpressed after host plant adaptation. This implies the existence of a transcriptional cascade linking phytochemicals to the induction of detoxification systems. , Although the induction of insect detoxification genes associated with insecticide tolerance after exposure to phytochemicals has been described, the transcriptional regulation of these genes remains unknown …”

Section: Introductionmentioning

confidence: 99%

“…This implies the existence of a transcriptional cascade linking phytochemicals to the induction of detoxification systems. 2,9 Although the induction of insect detoxification genes associated with insecticide tolerance after exposure to phytochemicals has been described, the transcriptional regulation of these genes remains unknown. 10 Gene expression is commonly regulated by an array of transacting transcription factors (TFs).…”

Section: ■ Introductionmentioning

confidence: 99%

Activation of the ROS/CncC and 20-Hydroxyecdysone Signaling Pathways Is Associated with Xanthotoxin-Induced Tolerance to λ-Cyhalothrin in Spodoptera litura

Lǚ

Cheng

et al. 2021

J. Agric. Food Chem.

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Adaptation to phytochemicals in herbivorous insects can influence tolerance to insecticides. However, it is unclear how insects use phytochemicals as cues to activate their metabolic detoxification systems. In this study, we found that dietary exposure to xanthotoxin enhanced tolerance of Spodoptera litura larvae to λ-cyhalothrin. Xanthotoxin ingestion significantly elevated the mRNA levels of 35 detoxification genes as well as the transcription factors Cap ‘n’ collar isoform-C (CncC) and its binding factor small muscle aponeurosis fibromatosis isoform-K (MafK). Additionally, xanthotoxin exposure increased the levels of reactive oxygen species (ROS), while ROS inhibitor N-acetylcysteine (NAC) treatment blocked xanthotoxin-induced expression of CncC, MafK, and detoxification genes and also prevented xanthotoxin-enhanced larval tolerance to λ-cyhalothrin. The 20-hydroxyecdysone (20E) signaling pathway was effectively activated by xanthotoxin, while blocking of 20E signaling transduction prevented xanthotoxin-enhanced larval tolerance to λ-cyhalothrin. Application of 20E induced the expression of multiple xanthotoxin-induced detoxification genes and enhanced λ-cyhalothrin tolerance in S. litura. NAC treatment blocked xanthotoxin-induced 20E synthesis, while the CncC agonist curcumin activated the 20E signaling pathway. These results indicate that the ROS/CncC pathway controls the induction of metabolic detoxification upon exposure to xanthotoxin, at least in part, through its regulation of the 20E signaling pathway.

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“…Insects have evolved different strategies to overcome insecticides and plant secondary compounds. Detoxification enzymes are the main mechanism of insect adaptation to synthetic and natural xenobiotics (Li et al 2007a; Schuler 2011; Feyereisen 2012; Heidel-Fischer and Vogel 2015; Lu et al 2020; Vandenhole et al 2020). UDP-glycosyltransferases and cytochrome P450 monooxygenases play an important role in the detoxification of flavonoids and terpenoids in insects (Luque and O’Reilly 2002; Huang et al 2008; Krempl et al 2016; Jin et al 2019).…”

Section: Discussionmentioning

confidence: 99%

Fitness costs associated with spinetoram resistance inSpodoptera frugiperdais driven by host plants

Kanno

Guidolin

Padovez

et al. 2021

Preprint

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Insecticide resistance is usually associated with fitness costs. The magnitude of fitness costs is affected by environmental and ecological factors. Here, we explored how host plants could affect fitness costs associated with insecticide resistance. Initially, spinetoram-resistant (RR) and susceptible (SS) strains of Spodoptera frugiperda were selected using F2 screen from a population collected in São Desidério, Bahia State, Brazil in 2018. Besides de RR and SS strains, fitness costs were also assessed for a heterozygous strain (RS). Life-history traits were evaluated to estimate population growth parameters of neonate larvae of each strain fed on corn, soybean and cotton plants. Compared to the SS strain, the relative fitness of the RR strain, based on intrinsic rate of population increase, was 1.06, 0.84 and 0.67 on plants of corn, soybean and cotton respectively. The relative fitness of the RS strain was similar to the SS strain regardless the host plant, suggesting a recessive fitness cost. No differences were found between the strains fed on corn plants. The larval development time was greater for RR strain fed on soybean and cotton plants compared to RS and SS strain. Low survival rate and fecundity of the RR strain were found when larvae fed on plants of soybean and cotton. The results of this study demonstrated that fitness costs of spinetoram resistance in S. frugiperda depend strongly on the host plants that S. frugiperda larvae fed on. Such information can be used to design resistance management strategies considering the host plants of the agricultural landscape.Key messagesThe presence of fitness costs associated with resistance can be exploited in resistance management strategies.Host plant influences the fitness costs associated with spinetoram resistance in S. frugiperda.Information considering the host plants in an agricultural landscape is essential to design effective resistance management programs.

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Short term transcriptional responses of P450s to phytochemicals in insects and mites

Cited by 52 publications

References 78 publications

The Role of Cytochrome P450s in Insect Toxicology and Resistance

The Role of Cytochrome P450s in Insect Toxicology and Resistance

Activation of the ROS/CncC and 20-Hydroxyecdysone Signaling Pathways Is Associated with Xanthotoxin-Induced Tolerance to λ-Cyhalothrin in Spodoptera litura

Fitness costs associated with spinetoram resistance inSpodoptera frugiperdais driven by host plants

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