Short-term treatment with proton pump inhibitors, H2-receptor antagonists and prokinetics for gastro-oesophageal reflux disease-like symptoms and endoscopy negative reflux disease.

Pinxteren, B. van; Numans, M. E.; Bonis, PA; Lau, Joseph

doi:10.1002/14651858.cd002095

Cited by 91 publications

(110 citation statements)

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“…Los Angeles grade C or D esophagitis provides robust evidence of GERD, 134 and also predicts the response to treatment. [135][136][137] Grade A alone is not sufficient for the diagnosis of GERD as it may be encountered in asymptomatic controls. 138 Most of patients with GERD symptoms have normal appearing mucosa on endoscopy, and examination of biopsies through conventional histology has shown limited value (i.e., low specificity) in documenting GERD.…”

Section: Esophageal Mucosal Lesion and Mucosal Integritymentioning

confidence: 99%

Ambulatory reflux monitoring for diagnosis of gastro‐esophageal reflux disease: Update of the Porto consensus and recommendations from an international consensus group

Roman

Gyawali

Savarino³

et al. 2017

Neurogastroenterology Motil

314

326

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Section: Esophageal Mucosal Lesion and Mucosal Integritymentioning

confidence: 99%

Ambulatory reflux monitoring for diagnosis of gastro‐esophageal reflux disease: Update of the Porto consensus and recommendations from an international consensus group

Roman

Gyawali

Savarino³

et al. 2017

Neurogastroenterology Motil

314

326

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“…Recommendation level: 1A. Explanation: There is sufficient evidence to show that PPI are effective for treating patients with normal GERD, 218,219 and they are assumed to be effective for treating GERD in patients with SSc. Other reports have stated that PPI are effective for treating GERD in patients with SSc, [220][221][222][223][224][225] and a random-sampling double-blind study showed that PPI are effective for treating patients with SSc, although the sample size was small.…”

Section: Cq3 Are Ppi Effective For Gerd?mentioning

confidence: 99%

Diagnostic criteria, severity classification and guidelines of systemic sclerosis

Asano

Jinnin

Kawaguchi

et al. 2018

The Journal of Dermatology

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Several effective drugs have been identified for the treatment of systemic sclerosis (SSc). However, in advanced cases, not only their effectiveness is reduced but they may be also harmful due to their side-effects. Therefore, early diagnosis and early treatment is most important for the treatment of SSc. We established diagnostic criteria for SSc in 2003 and early diagnostic criteria for SSc in 2011, for the purpose of developing evaluation of each organ in SSc. Moreover, in November 2013, the American College of Rheumatology and the European Rheumatology Association jointly developed new diagnostic criteria for increasing their sensitivity and specificity, so we revised our diagnostic criteria and severity classification of SSc. Furthermore, we have revised the clinical guideline based on the newest evidence. In particular, the clinical guideline was established by clinical questions based on evidence-based medicine according to the New Minds Clinical Practice Guideline Creation Manual (version 1.0). We aimed to make the guideline easy to use and reliable based on the newest evidence, and to present guidance as specific as possible for various clinical problems in treatment of SSc.

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“…In empiric trials of GERD, the relative risk for the resolution of heartburn with PPI therapy as compared to placebo was 0.37 (95% confidence interval [CI]: 0.32-0.44), and PPIs were significantly better than H2-RAs (relative risk 0.66, 95% CI: 0.60-0.73). 24 Current clinical guidelines support empirical therapy in GERD and recommend a trial of standard dose PPI therapy for 1-2 months in standard dose. 25,26 This strategy may also be the most cost-effective way of managing patients with reflux symptoms.…”

Section: A Clinical Practical Classification: Focus On Gastroesophagmentioning

confidence: 99%

Endoscopy of the esophagus in gastroesophageal reflux disease: are we losing sight of symptoms? Another perspective

Chey

Hunt

Laine³

et al. 2009

Diseases of the Esophagus

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Gastroesophageal reflux disease (GERD) is an extremely common chronic disorder associated with impaired quality of life and huge economic burden. Recently, an International Consensus Group developed a global definition of GERD (The Montreal Definition): a condition that develops when the reflux of stomach contents causes troublesome symptoms and/or complications. The traditional endoscopy-based classification of GERD patients into one of three groups - non-erosive reflux disease, erosive esophagitis, and Barrett's esophagus - is fraught with several limitations. Due to the lack of a gold standard, GERD is a symptom-based diagnosis, and hence symptom evaluation will remain the primary means by which treatment decisions are made for patients with suspected GERD. We propose that patients reporting the predominant GERD-like symptoms (GERS) in the primary care setting be classified based upon their response to an empiric trial of acid suppressive therapy: complete response to acid suppressive therapy, partial response to acid suppressive therapy, and no response to acid suppressive therapy. Given the limitations of objective medical testing, implementation of our proposed new symptom-based classification of patients with GERS would guide primary care physicians on when to refer patients to a gastroenterologist, which in turn could help in better resource utilization. Validation of this proposed classification by well-designed prospective multicenter studies is awaited.

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Short-term treatment with proton pump inhibitors, H2-receptor antagonists and prokinetics for gastro-oesophageal reflux disease-like symptoms and endoscopy negative reflux disease.

Cited by 91 publications

References 0 publications

Ambulatory reflux monitoring for diagnosis of gastro‐esophageal reflux disease: Update of the Porto consensus and recommendations from an international consensus group

Ambulatory reflux monitoring for diagnosis of gastro‐esophageal reflux disease: Update of the Porto consensus and recommendations from an international consensus group

Diagnostic criteria, severity classification and guidelines of systemic sclerosis

Endoscopy of the esophagus in gastroesophageal reflux disease: are we losing sight of symptoms? Another perspective

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