Short-term trivalent arsenic and hexavalent chromium exposures induce gut dysbiosis and transcriptional alteration in adipose tissue of mice

Singh, D. P.; Yadav, Shiv Kumar; Patel, Kevin; Patel, Shanaya; Patil, Gajanan P; Bijalwan, Vandana; Singh, Gyanendra; Palkhade, Rajendra; Kondepudi, Kanthi Kiran; Boparai, Ravneet K.; Bishnoi, Mahendra; Das, Santasabuj

doi:10.1007/s11033-022-07992-z

Cited by 9 publications

(2 citation statements)

References 47 publications

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“…Arsenic exposure can also decrease PDE3b (phosphodiesterase 3b) expression and activity, an enzyme that regulates lipolysis and glucose uptake in adipocytes, resulting in hyperglycemia and insulin resistance [164]. In addition, SREBP (a transcription factor that regulates lipid metabolism) and PPARg (a nuclear receptor that regulates adipogenesis and glucose metabolism) have both been shown to be activated by iAs in adipocytes, resulting in increased expression of lipogenic genes and adipogenesis, eventually leading to the development of obesity, insulin resistance, and hyperglycemia [164][165][166].…”

Section: Mechanisms Associated With Ias-induced Diabetogenesismentioning

confidence: 99%

Arsenic in Drinking Water and Diabetes

Shakya

Dodson

Artiola

et al. 2023

Water

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Arsenic is ubiquitous in soil and water environments and is consistently at the top of the Agency for Toxic Substances Disease Registry (ATSDR) substance priority list. It has been shown to induce toxicity even at low levels of exposure. One of the major routes of exposure to arsenic is through drinking water. This review presents current information related to the distribution of arsenic in the environment, the resultant impacts on human health, especially related to diabetes, which is one of the most prevalent chronic diseases, regulation of arsenic in drinking water, and approaches for treatment of arsenic in drinking water for both public utilities and private wells. Taken together, this information points out the existing challenges to understanding both the complex health impacts of arsenic and to implementing the treatment strategies needed to effectively reduce arsenic exposure at different scales.

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Section: Mechanisms Associated With Ias-induced Diabetogenesismentioning

confidence: 99%

Arsenic in Drinking Water and Diabetes

Shakya

Dodson

Artiola

et al. 2023

Water

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“…Correspondingly, in an in vitro study reduced brown adipogenesis and down-regulation of UCP1 expression significantly contribute to inhibition of thermogenesis upon As exposure [ 127 ]. In addition, As-induced alterations in gut microbiota including reduced relative abundance of Lactobacilli , Bifidobacteria , Akkermansia , Lachenospiraceae , Fecalibacterium , Eubacterium , and clostridium coccoid group with increased Enterobacteriaceae abundance may contribute to inhibition of adipogenesis, lipolysis, and thermogenesis in gonadal WAT, as well as increased adipogenesis and thermogenesis in BAT, as well as systemic inflammation [ 128 ]. It is also worth mentioning that Gong et al (2021) demonstrated transgenerational effect of paternal As exposure, characterized by reduced body adiposity in F2 offspring and increased susceptibility to diet-induced increase in body adiposity in F3 offspring [ 129 ].…”

Section: Introductionmentioning

confidence: 99%

Association between Heavy Metals, Metalloids and Metabolic Syndrome: New Insights and Approaches

Martins

Ferrer

Tinkov

et al. 2023

Toxics

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Metabolic syndrome (MetS) is an important public health issue that affects millions of people around the world and is growing to pandemic-like proportions. This syndrome is defined by the World Health Organization (WHO) as a pathologic condition characterized by abdominal obesity, insulin resistance, hypertension, and hyperlipidemia. Moreover, the etiology of MetS is multifactorial, involving many environmental factors, including toxicant exposures. Several studies have associated MetS with heavy metals exposure, which is the focus of this review. Environmental and/or occupational exposure to heavy metals are a major risk, contributing to the development of chronic diseases. Of particular note, toxic metals such as mercury, lead, and cadmium may contribute to the development of MetS by altering oxidative stress, IL-6 signaling, apoptosis, altered lipoprotein metabolism, fluid shear stress and atherosclerosis, and other mechanisms. In this review, we discuss the known and potential roles of heavy metals in MetS etiology as well as potential targeted pathways that are associated with MetS. Furthermore, we describe how new approaches involving proteomic and transcriptome analysis, as well as bioinformatic tools, may help bring about an understanding of the involvement of heavy metals and metalloids in MetS.

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Sub‐acute bisphenol A exposure induces proteomic alterations and impairs male reproductive health in mice

Yadav,

Kumar,

Yadav

et al. 2024

J Biochem & Molecular Tox

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Bisphenol A (BPA) is one of the most prevalent endocrine disrupting chemicals (EDCs) and there is widespread concern about the adverse effects of EDCs on human health. However, the exact mechanism of these toxicities has still not been fully deciphered. Additionally, studies have reported the toxicological effects at far low doses to the generally considered no‐observed‐adverse‐effect level (NOAEL) dose. The present study investigates the effects of a sub‐acute (28 days) exposure to BPA (10, 50 and 100 mg/kg/day) in adult male mice on various hormones levels, sperm motility, sperm count, functional integrity of sperm plasma membrane, testicular histological changes, oxidative stress markers and DNA damage. The key proteome signatures were quantified by LC‐MS/MS analysis using Orbitrap Fusion Lumos Tribrid Mass Spectrometer equipped with nano‐LC Easy‐nLC 1200. Data suggest that the BPA exposure in all doses (below/above NOAEL dose) have greatly impacted the hormone levels, sperm parameters (sperm count, motility and membrane integrity) and testicular histology. Mass spectrometry‐based proteomics data suggested for 1352 differentially expressed proteins (DEPs; 368 upregulated, 984 downregulated) affecting biological process, cellular component, and molecular functions. Specifically searched male reproductive function related proteins suggested a complex network where 46 potential proteins regulating spermatogenesis, sperm structure, activity and membrane integrity while tackling oxidative stress responses were downregulated. These potential biomarkers could shed some more light on our current understanding of the reproductive toxicological effects of BPA and may lead to exploration of novel interventions strategies against these targets for male infertility.

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Short-term trivalent arsenic and hexavalent chromium exposures induce gut dysbiosis and transcriptional alteration in adipose tissue of mice

Cited by 9 publications

References 47 publications

Arsenic in Drinking Water and Diabetes

Arsenic in Drinking Water and Diabetes

Association between Heavy Metals, Metalloids and Metabolic Syndrome: New Insights and Approaches

Sub‐acute bisphenol A exposure induces proteomic alterations and impairs male reproductive health in mice

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