Short-Term Use of Selective Serotonin Reuptake Inhibitors Increases Risk of Gastrointestinal Bleeding in Men With Psychiatric Diagnoses

Ayers, Katie; Waljee, Akbar K.; Saini, Sameer D.

doi:10.1053/j.gastro.2014.09.010

Cited by 6 publications

(2 citation statements)

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“…19 In contrast, a previous real-world study from Texas showed a smaller number of GI-bleeding events in patients taking NOAC than those receiving VKA; however, the number of patients treated with NOAC was small. [22][23][24][25][26][27][28] However, recent studies showed that a prestroke SSRI exposure was not associated with increased cerebral haemorrhage. 18,21 Conflicting results have been reported concerning the bleeding risk of patients receiving SSRI treatment in previous observational retrospective studies, which might be explained by different applied methodologies, health care system, selection bias, or follow-up periods.…”

Section: Resultsmentioning

confidence: 99%

“…In the general population, an increased risk of GI bleeding or blood transfusion was associated with SSRI intake. [22][23][24][25][26][27][28] However, recent studies showed that a prestroke SSRI exposure was not associated with increased cerebral haemorrhage. 29 In addition, investigations in patients undergoing cardiac surgery showed that SSRI exposure was not associated with increased bleeding risk or blood transfusion.…”

Section: Discussionmentioning

confidence: 99%

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SSRI co‐medication with NOAC or VKA does not increase hospitalisation for bleeding: A retrospective nationwide cohort study in Austria 2010‐2015

Sheikh

Mittlböck

Reichardt

et al. 2019

Int J Geriat Psychiatry

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Objectives Non‐vitamin K oral anticoagulants (NOACs) or vitamin K antagonists (VKAs) are used for the prophylaxis and treatment of thromboembolic events. A potential drug–drug interaction and increased bleeding events have been reported with co‐medication of selective serotonin receptor inhibitors (SSRIs) and VKA. The aim of this study was to investigate the bleeding risk of a coprescription of NOAC or VKA with SSRI. Methods Patients with prescription of NOAC or VKA and an antidepressant drug therapy (ADTx) were selected from the drug reimbursement database of 13 Austrian health insurance funds. For this cohort, hospital discharge diagnoses for gastrointestinal bleeding, cerebral haemorrhage, and bleeding anaemia between 2010 and 2015 were analysed. Results Data were available from 50 196 female and 31 308 male patients. Among these, 892 patients had 987 hospitalisations with bleeding events. The most frequent bleeding cases were gastrointestinal bleedings with 588 events (59.6%), followed by cerebral haemorrhage with 344 (34.8%), and bleeding anaemia with 55 events (5.6%), respectively. The risk of bleeding events was similar between SSRI and other ADTx, when combined with oral anticoagulants (p = 0.51). Concomitant treatment of patients with SSRI or other ADTx and NOAC was associated with an increased bleeding risk compared with cotreatment with VKA (1.21, 95% CI: 1.05‐1.40; p = 0.0097). Conclusion Co‐medication of SSRI with VKA or NOAC has little if any impact on hospital discharge diagnoses for bleeding events compared with cotreatment of those anticoagulants with other antidepressant medications.

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