Short therapy for tinea unguium with terbinafine: four different courses of treatment

Albanese, G; Cintio, R. Di; Martini, C.; Nicoletti, André Gustavo Bombana

doi:10.1111/j.1439-0507.1995.tb00051.x

Cited by 17 publications

(6 citation statements)

References 8 publications

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“…From these facts, it would be interesting to know whether or not pulse therapy with terbinafine is also effective. In this, some clinical trials have reported favorable results by intermittent dosing of terbinafine 4–8,12–14 …”

Section: Discussionmentioning

confidence: 99%

Combination of pulse therapy with terbinafine tablets and topical terbinafine cream for the treatment of dermatophyte onychomycosis: A pilot study

Nakano

Hiruma

Shiraki

et al. 2006

The Journal of Dermatology

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We performed a pilot study to assess the safety and efficacy of pulse therapy with terbinafine tablets in 66 patients with dermatophyte onychomycosis. One pulse consisted of oral terbinafine tablets (500 mg/day) given for 1 week followed by a 3-week interval. Topical 1% terbinafine cream was applied daily. The number of pulses was determined by the extent of improvement in the affected nails and by the patient's requests, up to a maximum of six pulses. Efficacy was assessed based on both clinical and mycological examinations 1 year after treatment initiation. We observed a complete cure in 51 patients (77.3%), marked improvement in five patients (7.6%), improvement in five patients (7.6%) and slight improvement in one patient (1.5%). Four patients (6.0%) showed no change. In the patients who were completely cured, the average number of pulses used was 3.7 +/- 1.4 pulses and the treatment duration was 3.3 +/- 1.6 months. Nine patients experienced adverse effects, consisting of gastrointestinal disturbance (eight patients) and drug-induced eruption (one patient). There were no abnormal findings in the laboratory tests, including liver function tests. In summary, terbinafine pulse therapy in combination with topical application of terbinafine cream appeared safe and effective in this pilot study.

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Section: Discussionmentioning

confidence: 99%

Combination of pulse therapy with terbinafine tablets and topical terbinafine cream for the treatment of dermatophyte onychomycosis: A pilot study

Nakano

Hiruma

Shiraki

et al. 2006

The Journal of Dermatology

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“…[115][116][117] The combination of daily terbinafi ne doses (250 mg) with chemical or mechanical removal of the nail offers little to no additional increase in effi cacy over terbinafi ne alone. 118,119 Similarly, only limited increases in effi cacy are observed when daily oral therapy is combined with adjunctive therapy including once-weekly topical amorolfi ne or once-daily topical ciclopirox. [120][121][122][123] In each study topical therapy appeared to confer slight improvements in response; however, limited sample sizes restrict their signifi cance and superiority over terbinafi ne alone could not be determined.…”

Section: Onychomycosismentioning

confidence: 99%

Update on terbinafine with a focus on dermatophytoses

Newland¹,

Abdel‐Rahman

2009

CCID

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Since terbinafi ne was introduced on the world market 17 years ago, it has become the leading antifungal for the treatment of superfi cial fungal infections, aided by unique pharmacologic and microbiologic profi les. This article reviews mode of action, antimycotic spectrum and disposition profi le of terbinafi ne. It examines the data, accumulated over 15 years, on the comparative effi cacy of terbinafi ne (vs griseofulvin, itraconazole, fl uconazole) in the management of the infections for which it is primarily indicated (eg, dermatophytoses) and provides a brief discussion on its use for the treatment of non-dermatophyte infections. Finally, the available data on the newest topical and systemic formulations are introduced.

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“…Intermittent dosing of terbinafine appeared to produce good treatment results in some clinical trials. 9,10,[14][15][16] The present study was designed to consider the pharmacokinetic properties of terbinafine and the standard dose in Japan.…”

Section: Discussionmentioning

confidence: 99%

Combination therapy consisting of week pulses of oral terbinafine plus topical application of terbinafine cream in the treatment of onychomycosis

Sanmano

Hiruma

Mizoguchi

et al. 2004

Journal of Dermatological Treatment

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Short therapy for tinea unguium with terbinafine: four different courses of treatment

Cited by 17 publications

References 8 publications

Combination of pulse therapy with terbinafine tablets and topical terbinafine cream for the treatment of dermatophyte onychomycosis: A pilot study

Combination of pulse therapy with terbinafine tablets and topical terbinafine cream for the treatment of dermatophyte onychomycosis: A pilot study

Update on terbinafine with a focus on dermatophytoses

Combination therapy consisting of week pulses of oral terbinafine plus topical application of terbinafine cream in the treatment of onychomycosis

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