We show that in dimension 4 and above, the lifespan of Ricci flows depends on the relative smallness of the Ricci curvature compared to the Riemann curvature on the initial manifold. We can generalize this lifespan estimate to the local Ricci flow, using which we prove the short-time existence of Ricci flow solutions on noncompact Riemannian manifolds with at most quadratic curvature growth, whose Ricci curvature and its first two derivatives are sufficiently small in regions where the Riemann curvature is large. Those Ricci flow solutions may have unbounded curvature. Moreover, our method implies that, under some appropriate assumptions, the spatial transfer rate (the rate at which high curvature regions affect low curvature regions) of the Ricci flow resembles that of the heat equation. √ K , and if |Rm|(x, t) ≤ K f or all (x, t) ∈ U × [0, T ],andthen |∇ m Rm|(y, t) ≤ CK 1+min{m,l}/2 t (m−l)+/2 for all (y, t) ∈ B g(0) (p, r 2 ) × (0, T ]. Recall that in Theorem 0.1 we have uniform curvature assumptions that sup M |Rm| ≤ K and |∇ m Ric| ≤ K 1+m/2 e −AK for m = 0, 1, 2, where A ≥ 0. And we use T d to denote the first time that sup M |Rm|(t) becomes 2K.Proof of Theorem 0.1. We proof this theorem in three steps.Step 1: Control the first two derivatives of Rm.By Lemma 1.1, sup M |∇Rm|(0) ≤ C(n)K 3/2 .