Short wavelength-automated perimetry compared with standard achromatic perimetry in autosomal dominant optic atrophy

Walters, James W.; Gaume, Amber; Pate, Lloyd

doi:10.1136/bjo.2006.097196

Cited by 11 publications

(8 citation statements)

References 9 publications

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“…Visual loss occurs gradually and clinical diagnosis is typically made in the first two decades of life (Newman 2005). Visual field defects include central, paracentral and centrocecal scotomata, in agreement with the typical temporal pallor of the optic nerve head (Walters et al 2006). Histopathology reports describe selective loss of macular ganglion cells and nerve fibres in the papillomacular bundle (Johnston et al 1979;Kjer et al 1983 …”

Section: Introductionmentioning

confidence: 81%

Axonal loss occurs early in dominant optic atrophy

Miléa

Sander

Wegener

et al. 2010

Acta Ophthalmologica

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. Purpose: This study set out to investigate retinal nerve fibre layer (RNFL) thickness and best corrected visual acuity (BCVA) in relation to age in healthy subjects and patients with OPA1 autosomal dominant optic atrophy (DOA). Methods: We carried out a cross‐sectional investigation of RNFL thickness and ganglion cell layer density in 30 healthy subjects and 10 patients with OPA1 DOA using optical coherence tomography (OCT). We then performed a regression analysis of RNFL thickness and BCVA versus age. Results: Both healthy subjects and DOA patients demonstrated a gradual reduction in RNFL thickness with age; the relationship was best described statistically by a model that assumed a constant offset between the two groups. Best corrected VA decreased significantly with age in DOA patients, in whom BCVA was correlated with peripapillary RNFL thickness in the inferior and superior peripapillary quadrants and with total macular thickness at eccentricities of 500–3000 μm. The observations were best described by a constant offset of 41.9 μm separating the two groups and an annual decrease in RNFL thickness of 0.48 μm (p < 0.0001). In patients with DOA, increasing age was associated with decreasing BCVA (p = 0.046). Conclusions: This cross‐sectional study found evidence of comparable age‐related decreases in RNFL thickness in healthy subjects and in DOA patients, where the deficit in DOA patients is best described using a model that assumes the deficit between the groups does not vary with age. The gradual reduction of BCVA with age may be a consequence of a relative deficit in RNFL thickness that is established before the second decade of life.

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Section: Introductionmentioning

confidence: 81%

Axonal loss occurs early in dominant optic atrophy

Miléa

Sander

Wegener

et al. 2010

Acta Ophthalmologica

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“…[ 48 ] The field defects seem to be significantly worse when tested with short wavelength automated perimetry (SWAP) where the MD were depressed 10–20 times more than MD in SAP. [ 49 ]…”

Section: Ischemic Optic Neuropathymentioning

confidence: 99%

Visual fields in neuro-ophthalmology

Kedar

Ghate

Corbett

2011

Indian J Ophthalmol

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Visual field assessment is important in the evaluation of lesions involving the visual pathways and should be performed at baseline and periodically in the follow-up. Standard automated perimetry has been shown to be adequate in neuro-ophthalmic practise and is now the technique of choice for a majority of practitioners. Goldman kinetic visual fields are useful for patients with severe visual and neurologic deficits and patients with peripheral visual field defects. Visual fields are useful in monitoring progression or recurrence of disease and guide treatment for conditions such as idiopathic intracranial hypertension (IIH), optic neuropathy from multiple sclerosis, pituitary adenomas, and other sellar lesions. They are used as screening tools for toxic optic neuropathy from medications such as ethambutol and vigabatrin. Visual field defects can adversely affect activities of daily living such as personal hygiene, reading, and driving and should be taken into consideration when planning rehabilitation strategies. Visual field testing must be performed in all patients with lesions of the visual pathway.

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“…Loss of perception of the blue colors in DOA was also among the early observations by Kjer 7 and the most frequently reported color vision defect in this disorder. 1 , 4 , 25 – 29 Reports showing clear age-related variations are, however, scarce; and this could be explained by the differences in the testing conditions used. The Trivector test procedure of the CCT enables better discrimination and quantitative assessment of the individual color axes than the elliptical test procedure previously used in another study.…”

Section: Discussionmentioning

confidence: 99%

“…In the context of DOA, psychophysical studies have focused mainly on color vision and have shown various deficits that tended to be most severe for discrimination along the tritan axis. 1 , 25 – 29 There are two reports detailing deficits in the parvocellular and magnocellular pathways in DOA, with one showing abnormal achromatic contrast sensitivities and the other abnormal peripheral motion detection thresholds. 1 , 28 Although both parvocellular and magnocellular pathways seem to be involved in visually affected patients, the severity and progression of deficits with increasing age remain unclear.…”

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confidence: 99%

The Pattern of Retinal Ganglion Cell Loss in OPA1-Related Autosomal Dominant Optic Atrophy Inferred From Temporal, Spatial, and Chromatic Sensitivity Losses

Majander

João

Rider

et al. 2017

Invest. Ophthalmol. Vis. Sci.

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PurposeProgressive retinal ganglion cell (RGC) loss is the pathological hallmark of autosomal dominant optic atrophy (DOA) caused by pathogenic OPA1 mutations. The aim of this study was to conduct an in-depth psychophysical study of the visual losses in DOA and to infer any selective vulnerability of visual pathways subserved by different RGC subtypes.MethodsWe recruited 25 patients carrying pathogenic OPA1 mutations and age-matched healthy individuals. Spatial contrast sensitivity functions (SCSFs) and chromatic contrast sensitivity were quantified, the latter using the Cambridge Colour Test. In 11 patients, long (L) and short (S) wavelength–sensitive cone temporal acuities were measured as a function of target illuminance, and L-cone temporal contrast sensitivity (TCSF) as a function of temporal frequency.ResultsSpatial contrast sensitivity functions were abnormal, with the loss of sensitivity increasing with spatial frequency. Further, the highest L-cone temporal acuity fell on average by 10 Hz and the TCSFs by 0.66 log10 unit. Chromatic thresholds along the protan, deutan, and tritan axes were 8, 9, and 14 times higher than normal, respectively, with losses increasing with age and S-cone temporal acuity showing the most significant age-related decline.ConclusionsLosses of midget parvocellular, parasol magnocellular, and bistratified koniocellular RGCs could account for the losses of high spatial frequency sensitivity and protan and deutan sensitivities, high temporal frequency sensitivity, and S-cone temporal and tritan sensitivities, respectively. The S-cone–related losses showed a significant deterioration with increasing patient age and could therefore prove useful biomarkers of disease progression in DOA.

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Short wavelength-automated perimetry compared with standard achromatic perimetry in autosomal dominant optic atrophy

Cited by 11 publications

References 9 publications

Axonal loss occurs early in dominant optic atrophy

Axonal loss occurs early in dominant optic atrophy

Visual fields in neuro-ophthalmology

The Pattern of Retinal Ganglion Cell Loss in OPA1-Related Autosomal Dominant Optic Atrophy Inferred From Temporal, Spatial, and Chromatic Sensitivity Losses

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