Short-wavelength blue light contributes to the pyroptosis of human lens epithelial cells (hLECs)

Wang, Xiaohui; Song, Zhaowei; Li, Huazhang; Liu, Kexin; Sun, Ying; Liu, Xiangyu; Yang, Y; Shen, Sheng; Z, Li

doi:10.1016/j.exer.2021.108786

Cited by 8 publications

(3 citation statements)

References 27 publications

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“…For example, 808-nm infrared is absorbed in the iris and transformed into heat, which is subsequently transmitted to the lens and produces cataracts [ 65 ]. Short-wave blue light induces programmed inflammatory cell death by activating the gasdermin D signaling axis, leading to pyroptosis of human lens epithelial cells (hLECs) [ 66 ]. One study investigated the impact of ionizing radiation on the production of reactive oxygen species (ROS) and nitrogen species (RNS) in hLECs, indicating that ROS and RNS play a significant role in radiation-induced injury and that the extent of damage varies with the dose and dose rate of IR exposure [ 67 ].…”

Section: Discussionmentioning

confidence: 99%

A bibliometric and visualized analysis of the pathogenesis of cataracts from 1999 to 2023

Shu,

Liu,

et al. 2024

Heliyon

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Section: Discussionmentioning

confidence: 99%

A bibliometric and visualized analysis of the pathogenesis of cataracts from 1999 to 2023

Shu,

Liu,

et al. 2024

Heliyon

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“…Sun et al showed that CRTAC1-mediated UVB-induced pyroptosis in human LECs occurs via ROS/NLRP3/CASP1 signaling [ 20 ]. Other studies have shown that short-wavelength blue light induces pyroptosis by activating the canonical or noncanonical CASP1/GSDMD signaling axis in LECs [ 220 , 222 ]. In addition, the expression levels of CASP1 and GSDMD in LECs changed with blue light exposure times [ 222 ].…”

Section: Pyroptosis In Ocular Diseasesmentioning

confidence: 99%

Spotlight on pyroptosis: role in pathogenesis and therapeutic potential of ocular diseases

Chen

Rong

Xia

2022

J Neuroinflammation

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Pyroptosis is a programmed cell death characterized by swift plasma membrane disruption and subsequent release of cellular contents and pro-inflammatory mediators (cytokines), including IL‐1β and IL‐18. It differs from other types of programmed cell death such as apoptosis, autophagy, necroptosis, ferroptosis, and NETosis in terms of its morphology and mechanism. As a recently discovered form of cell death, pyroptosis has been demonstrated to be involved in the progression of multiple diseases. Recent studies have also suggested that pyroptosis is linked to various ocular diseases. In this review, we systematically summarized and discussed recent scientific discoveries of the involvement of pyroptosis in common ocular diseases, including diabetic retinopathy, age-related macular degeneration, AIDS-related human cytomegalovirus retinitis, glaucoma, dry eye disease, keratitis, uveitis, and cataract. We also organized new and emerging evidence suggesting that pyroptosis signaling pathways may be potential therapeutic targets in ocular diseases, hoping to provide a summary of overall intervention strategies and relevant multi-dimensional evaluations for various ocular diseases, as well as offer valuable ideas for further research and development from the perspective of pyroptosis.

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“…Moreover, a high level of CRTAC1 plays an important role in pyroptosis in cataracts, while the downregulation of CRTAC1 significantly attenuates UVB-induced pyroptosis ( Sun et al, 2020 ). In addition to the canonical inflammasome pathway, non-canonical inflammasomes are involved in caspase-11–triggered and GSDMD-triggered cataracts in a pyroptosis-dependent manner in short-wavelength blue light–exposed rat lens cells ( Wang X. et al, 2021 ). A recent study demonstrated that the expression of the pyroptosis markers caspase-1, caspase-11, and GSDMD in rat LECs was increased after short-wavelength blue light exposure ( Wang et al, 2020 ).…”

Section: Ocular Diseases Inflammasomes and Pyroptosismentioning

confidence: 99%

Pyroptosis: A New Insight Into Eye Disease Therapy

Zhang

Yan

et al. 2021

Front. Pharmacol.

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Pyroptosis is a lytic form of programmed cell death mediated by gasdermins (GSDMs) with pore-forming activity in response to certain exogenous and endogenous stimuli. The inflammasomes are intracellular multiprotein complexes consisting of pattern recognition receptors, an adaptor protein ASC (apoptosis speck-like protein), and caspase-1 and cause autocatalytic activation of caspase-1, which cleaves gasdermin D (GSDMD), inducing pyroptosis accompanied by cytokine release. In recent years, the pathogenic roles of inflammasomes and pyroptosis in multiple eye diseases, including keratitis, dry eyes, cataracts, glaucoma, uveitis, age-related macular degeneration, and diabetic retinopathy, have been continuously confirmed. Inhibiting inflammasome activation and abnormal pyroptosis in eyes generally attenuates inflammation and benefits prognosis. Therefore, insight into the pathogenesis underlying pyroptosis and inflammasome development in various types of eye diseases may provide new therapeutic strategies for ocular disorders. Inhibitors of pyroptosis, such as NLRP3, caspase-1, and GSDMD inhibitors, have been proven to be effective in many eye diseases. The purpose of this article is to illuminate the mechanism underlying inflammasome activation and pyroptosis and emphasize its crucial role in various ocular disorders. In addition, we review the application of pyroptosis modulators in eye diseases.

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Short-wavelength blue light contributes to the pyroptosis of human lens epithelial cells (hLECs)

Cited by 8 publications

References 27 publications

A bibliometric and visualized analysis of the pathogenesis of cataracts from 1999 to 2023

A bibliometric and visualized analysis of the pathogenesis of cataracts from 1999 to 2023

Spotlight on pyroptosis: role in pathogenesis and therapeutic potential of ocular diseases

Pyroptosis: A New Insight Into Eye Disease Therapy

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