Shortened telomere length is associated with paroxysmal atrial fibrillation among cardiovascular patients enrolled in the Intermountain Heart Collaborative Study

Carlquist, John F.; Knight, Stacey; Cawthon, Richard M.; Le, Viet T; Bunch, T. Jared; Horne, Benjamin D.; Rollo, Jeffrey; Huntinghouse, John; Muhlestein, Joseph B.; Anderson, Jeffrey L.

doi:10.1016/j.hrthm.2015.07.032

Cited by 46 publications

(53 citation statements)

References 26 publications

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“…Shorter telomere length is associated with a wide range of age‐related chronic diseases, such as hypertension, insulin resistance, vascular dementia, myocardial infarction, and stroke . Only a few studies have investigated the association between shorter telomere length and the age‐related disease AF, and the studies reported opposing results with only 1 study supporting the association …”

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confidence: 99%

Association Between Leukocyte Telomere Length and the Risk of Incident Atrial Fibrillation: The Framingham Heart Study

Stærk

Wang

Lunetta

et al. 2017

JAHA

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BackgroundAdvancing age is a prominent risk factor for atrial fibrillation (AF). Shorter telomere length is a biomarker of biological aging, but the link between shorter telomere length and increased risk of AF remains unclear. We examined the association between shorter leukocyte telomere length (LTL) and incident AF.Methods and ResultsWe included AF‐free participants from the observational Framingham Heart Study Offspring cohort from 1995 to 1998, who had LTL measurements. We examined the association between baseline LTL and incident AF with multivariable Cox models adjusted for age, sex, current smoking, height, weight, systolic and diastolic blood pressure, use of antihypertensive medication, diabetes mellitus, history of myocardial infarction, and history of heart failure. The study sample comprised 1143 AF‐free participants (52.8% women), with mean age of 60±8 years. The mean LTL at baseline was 6.95±0.57 kb. During 15.1±4.2 years mean follow‐up, 184 participants (64 women) developed AF. Chronological age was associated with increased risk of AF (hazard ratio per 10‐year increase, 2.16; 95% confidence interval, 1.71–2.72). There was no significant association between LTL and incident AF (hazard ratio per 1 SD decrease LTL, 1.01; 95% confidence interval, 0.86–1.19). Our study was observational in nature; hence, we could not exclude residual confounding and we were unable to establish causal pathways.ConclusionsIn our moderate‐sized community‐based cohort, we did not find evidence for a significant association between LTL and risk of incident AF.

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confidence: 99%

Association Between Leukocyte Telomere Length and the Risk of Incident Atrial Fibrillation: The Framingham Heart Study

Stærk

Wang

Lunetta

et al. 2017

JAHA

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show abstract

“…Advancing age is considered to be a significant risk factor for atrial fibrillation (AF). Several studies have reported an increasing prevalence of AF with age, taking a value of 4% in individuals older than 60 years and 8% in those older than 80 years . However, the underlying mechanisms underlying aging‐related AF remain incompletely elucidated.…”

Section: Introductionmentioning

confidence: 99%

“…However, the underlying mechanisms underlying aging‐related AF remain incompletely elucidated. AF is an important clinical condition as it shows a strong association with higher hospitalization rate, and higher mortality, and a poorer quality of life, as well as displaying a slight preponderance toward males . It is therefore important to identify the patients who are at risk of developing AF.…”

Section: Introductionmentioning

confidence: 99%

“…However, its association with AF has not been addressed. A retrospective study performed by Carlquist et al has shown that subjects with paroxysmal AF rather than persistent AF or permanent AF have significantly shorter telomere length than those without AF. In the present study, we conducted a prospective cohort study to determine the association between LTL and PAF, followed by a systematic review and meta‐analysis of published literature on this issue.…”

Section: Introductionmentioning

confidence: 99%

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Leucocyte telomere length and paroxysmal atrial fibrillation: A prospective cohort study and systematic review with meta‐analysis

Zhang

Fan

Gong

et al. 2018

Clinical Laboratory Analysis

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“…Although not coding proteins, microRNA has pluripotent biological functions, including modulation of cell growth and survival [11], as well as regulating cell proliferation, cell cycle [12], autophagy, and the signaling pathway [13]. …”

Section: Introductionmentioning

confidence: 99%

Functional Role and Mechanism of microRNA-28b in Atrial Myocyte in a Persistent Atrial Fibrillation Rat Model

Wang

Kang

et al. 2016

Med Sci Monit

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BackgroundPersistent atrial fibrillation has been indicated to be related with microRNA-28b. However, the exact role of microRNA-28b in persistent atrial fibrillation needs to be further elucidated. Therefore, this study aimed to establish a rat model of persistent atrial fibrillation to investigate the level of microRNA-28b in atrial myocytes and to explore the molecular mechanism involved.Material/MethodsA persistent atrial fibrillation model was established in rats by using chronic rapid atrial pacing induction. The size of the heart was measured by ultrasonic method. The expression of microRNA-28b in left atrial myocytes was quantified by RT-PCR. Cardiomyocytes were isolated and cultured to detect cell proliferation and apoptosis by MTT and flow cytometry, respectively. The specific inhibitor of ERK signaling pathway, PD98059, was used to further illustrate the role of ERK signaling pathway in the modulation of cardiomyocytes in persistent atrial fibrillation.ResultsMicroRNA-28b was up-regulated in the experimental rat model with persistent atrial fibrillation. The proliferation of cardiomyocytes was significantly inhibited with potentiated apoptosis. Blockage of the ERK pathway suppressed the microRNA-28b expression and inhibited cell apoptosis.ConclusionsmicroRNA-28b-induced growth inhibition and cell apoptosis of atrial myocytes was observed in the rat model with persistent atrial fibrillation, via activation of the ERK signaling pathway.

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Shortened telomere length is associated with paroxysmal atrial fibrillation among cardiovascular patients enrolled in the Intermountain Heart Collaborative Study

Cited by 46 publications

References 26 publications

Association Between Leukocyte Telomere Length and the Risk of Incident Atrial Fibrillation: The Framingham Heart Study

Association Between Leukocyte Telomere Length and the Risk of Incident Atrial Fibrillation: The Framingham Heart Study

Leucocyte telomere length and paroxysmal atrial fibrillation: A prospective cohort study and systematic review with meta‐analysis

Functional Role and Mechanism of microRNA-28b in Atrial Myocyte in a Persistent Atrial Fibrillation Rat Model

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