Shortening amplitude affects the incomplete force recovery after active shortening in mouse soleus muscle

Noten, Pieter Van; Leemputte, Marc Van

doi:10.1016/j.jbiomech.2009.08.027

Cited by 5 publications

(1 citation statement)

References 35 publications

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“…Work (W) is determined by shortening amplitude (AMP) and force during shortening (F s ) and both factors have been shown to affect FD. Indeed, a strong linear relationship between AMP and FD has been observed (Abbott and Aubert 1952;Herzog and Leonard 1997;Schachar et al 2002;Van Noten and Van Leemputte 2009) yet the slope of this relationship seems muscle length dependent (Maréchal and Plaghki 1979). The relationship between F s and FD has been studied by changing shortening velocity (Herzog et al 2000) and activation level (Leonard and Herzog 2005), both affecting the force production during shortening.…”

Section: Introductionmentioning

confidence: 99%

The effect of muscle length on force depression after active shortening in soleus muscle of mice

Noten

Leemputte

2010

Eur J Appl Physiol

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Isometric muscle force after active shortening is reduced [force depression (FD)]. The mechanism is incompletely understood but work delivered during shortening has been suggested to be the main determinant of FD. However, whether muscle length affects the sensitivity of FD to work is unknown, although this information might add to the understanding of the phenomenon. The aim of this study is to investigate the length dependence of the FD/work ratio (Q). Therefore, isometric force production (ISO) of 10 incubated mouse soleus muscles was compared to isometric force after 0.6, 1.2, and 2.4 mm shortening (IAS) at different end lengths ranging from L(0) - 3 to L(0) + 1.8 mm in steps of 0.6 mm. FD was calculated as the force difference between an ISO and IAS contraction at the same activation time (6 s) and end length. We confirm the strong relation between FD and work at L(0) (R² = 0.92) and found that FD is length dependent with a maximum of 8.8 ± 0.3% at L(0) + 1.2 mm for 0.6 mm shortening amplitude. Q was only constant for short muscle lengths (<85% L(0)) but increased exponentially with increasing muscle length. The observed length dependence of Q indicates that FD is not only determined by work produced during shortening but also by a length-dependent factor, possibly actin compliance, which should be incorporated in any mechanism explaining FD.

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Section: Introductionmentioning

confidence: 99%

The effect of muscle length on force depression after active shortening in soleus muscle of mice

Noten

Leemputte

2010

Eur J Appl Physiol

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Force depression and relaxation kinetics after active shortening and deactivation in mouse soleus muscle

Noten

Leemputte

2013

Journal of Biomechanics

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A cross-bridge based model of force depression: Can a single modification address both transient and steady-state behaviors?

Corr

Herzog

2016

Journal of Biomechanics

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Force depression (FD), the reduction of isometric force following active shortening, is a phenomenon of skeletal muscle that has received significant attention in biomechanical and physiological literature, yet the mechanisms underlying FD remain unknown. Recent experiments identified a slower rate of force redevelopment with increasing amounts of steady-state FD, suggesting that FD may be caused, at least in part, by a decrease in cross-bridge binding rate (Corr and Herzog, 2005; Koppes et al., 2014). Herein, we develop a cross-bridge based model of FD in which the binding rate function, f, decreases with the mechanical work performed during shortening. This modification incorporates a direct relationship between steady-state FD and muscle mechanical work (Corr and Herzog, 2005; Herzog et al., 2000; Kosterina et al., 2008), and is consistent with a proposed mechanism attributing FD to stress-induced inhibition of cross-bridge attachments (Herzog, 1998; Maréchal and Plaghki, 1979). Thus, for an increase in mechanical work, the model should predict a slower force redevelopment (decreased attachment rate) to a more depressed steady-state force (fewer attached cross-bridges), and a reduction in contractile element stiffness (Ford et al., 1981). We hypothesized that since this modification affects the cross-bridge kinetics, a corresponding model would be able to account for both transient and steady-state FD behaviors. Comparisons to prior experiments (Corr and Herzog, 2005; Herzog et al., 2000; Kosterina et al., 2008) show that both steady-state and transient aspects of FD, as well as the relationship of FD with respect to speed and amplitude of shortening, are well captured by this model. Thus, this relatively simple cross-bridge based model of FD lends support to a mechanism involving the inhibition of cross-bridge binding, and indicates that cross-bridge kinetics may play a critical role in FD.

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Shortening amplitude affects the incomplete force recovery after active shortening in mouse soleus muscle

Cited by 5 publications

References 35 publications

The effect of muscle length on force depression after active shortening in soleus muscle of mice

The effect of muscle length on force depression after active shortening in soleus muscle of mice

Force depression and relaxation kinetics after active shortening and deactivation in mouse soleus muscle

A cross-bridge based model of force depression: Can a single modification address both transient and steady-state behaviors?

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