Shortwave-infrared (SWIR) fluorescence molecular imaging using indocyanine green–antibody conjugates for the optical diagnostics of cancerous tumours

Tsuboi, Setsuko

doi:10.1039/d0ra04710d

Cited by 19 publications

(14 citation statements)

References 76 publications

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“…10 Recently, we reported that ICG-annexin V can act as a NIR uorescent dye for cancer cell apoptosis in vitro and in vivo. 22 ICG and ICG-C11 conjugated annexin V (ICG-annexin V and ICG-C11-annexin V) recognize PS on the plasma membrane of apoptotic cells, and they emit SWIR uorescence over 1000 nm (Scheme 1b). Using the annexin V probes, we examined the performance of SWIR uorescence for high-contrast molecular imaging of tumor apoptosis in living mice.…”

Section: Preparation Of Swir Emitting Annexin Vmentioning

confidence: 99%

Shortwave-infrared (SWIR) emitting annexin V for high-contrast fluorescence molecular imaging of tumor apoptosis in living mice

et al. 2022

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Section: Preparation Of Swir Emitting Annexin Vmentioning

confidence: 99%

Shortwave-infrared (SWIR) emitting annexin V for high-contrast fluorescence molecular imaging of tumor apoptosis in living mice

et al. 2022

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“…32,38 However, its major limitations include relatively low photon utilization because NIR-II is only the tail portion of the emission spectrum, as well as the nonspecific targeting mechanism of the EPR effect; 39 hence, researchers continue to identify strategies to improve characteristics of NIR-II imaging probes, such as synthesizing organic small molecules with a rapid excretion profile and higher imaging quality compared with free ICG, 40 and conjugating ICG to antibodies targeting overexpressed receptors on cancer cells. 41…”

Section: Icg In the Nir-ii Windowmentioning

confidence: 99%

Applications of indocyanine green in brain tumor surgery: review of clinical evidence and emerging technologies

Teng

Huang

Arguelles

et al. 2021

Neurosurgical Focus

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Indocyanine green (ICG) is a water-soluble dye that was approved by the FDA for biomedical purposes in 1956. Initially used to measure cardiocirculatory and hepatic functions, ICG’s fluorescent properties in the near-infrared (NIR) spectrum soon led to its application in ophthalmic angiography. In the early 2000s, ICG was formally introduced in neurosurgery as an angiographic tool. In 2016, the authors’ group pioneered a novel technique with ICG named second-window ICG (SWIG), which involves infusion of a high dose of ICG (5.0 mg/kg) in patients 24 hours prior to surgery. To date, applications of SWIG have been reported in patients with high-grade gliomas, meningiomas, brain metastases, pituitary adenomas, craniopharyngiomas, chordomas, and pinealomas.The applications of ICG have clearly expanded rapidly across different specialties since its initial development. As an NIR fluorophore, ICG has advantages over other FDA-approved fluorophores, all of which are currently in the visible-light spectrum, because of NIR fluorescence’s increased tissue penetration and decreased autofluorescence. Recently, interest in the latest applications of ICG in brain tumor surgery has grown beyond its role as an NIR fluorophore, extending into shortwave infrared imaging and integration into nanotechnology. This review aims to summarize reported clinical studies on ICG fluorescence–guided surgery of intracranial tumors, as well as to provide an overview of the literature on emerging technologies related to the utility of ICG in neuro-oncological surgeries, including the following aspects: 1) ICG fluorescence in the NIR-II window; 2) ICG for photoacoustic imaging; and 3) ICG nanoparticles for combined diagnostic imaging and therapy (theranostic) applications.

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“…Furthermore, it would have a higher spatial resolution than the sentinel lymph-node biopsy with VIS (Patent blue) or NIR fluorescence (Indocyanine green, ICG) because of the lower scattering property [ 6 , 7 , 8 , 9 ]. Indeed, a fluorescent image of a small breast cancer of several millimeters was obtained from small animal experiments [ 10 ].…”

Section: Introductionmentioning

confidence: 99%

Monte Carlo Modeling of Shortwave-Infrared Fluorescence Photon Migration in Voxelized Media for the Detection of Breast Cancer

et al. 2020

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Recent progress regarding shortwave-infrared (SWIR) molecular imaging technology has inspired another modality of noninvasive diagnosis for early breast cancer detection in which previous mammography or sonography would be compensated. Although a SWIR fluorescence image of a small breast cancer of several millimeters was obtained from experiments with small animals, detailed numerical analyses before clinical application were required, since various parameters such as size as well as body hair differed between humans and small experimental animals. In this study, the feasibility of SWIR was compared against visible (VIS) and near-infrared (NIR) region, using the Monte Carlo simulation in voxelized media. In this model, due to the implementation of the excitation gradient, fluorescence is based on rational mechanisms, whereas fluorescence within breast cancer is spatially proportional to excitation intensity. The fluence map of SWIR simulation with excitation gradient indicated signals near the upper surface of the cancer, and stronger than those of the NIR. Furthermore, there was a dependency on the fluence signal distribution on the contour of the breast tissue, as well as the internal structure, due to the implementation of digital anatomical data for the Visible Human Project. The fluorescence signal was observed to become weaker in all regions including the VIS, the NIR, and the SWIR region, when fluorescence-labeled cancer either became smaller or was embedded in a deeper area. However, fluorescence in SWIR alone from a cancer of 4 mm diameter was judged to be detectable at a depth of 1.4 cm.

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Shortwave-infrared (SWIR) fluorescence molecular imaging using indocyanine green–antibody conjugates for the optical diagnostics of cancerous tumours

Abstract: We present indocyanine green (ICG)-based shortwave-infrared (SWIR) fluorescence molecular imaging for the highly-sensitive optical detection of breast and skin tumours in mice.

Cited by 19 publications

References 76 publications

Shortwave-infrared (SWIR) emitting annexin V for high-contrast fluorescence molecular imaging of tumor apoptosis in living mice

Shortwave-infrared (SWIR) emitting annexin V for high-contrast fluorescence molecular imaging of tumor apoptosis in living mice

Applications of indocyanine green in brain tumor surgery: review of clinical evidence and emerging technologies

Monte Carlo Modeling of Shortwave-Infrared Fluorescence Photon Migration in Voxelized Media for the Detection of Breast Cancer

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