Shouhui Tongbian Capsule ameliorates constipation via gut microbiota-5-HT-intestinal motility axis

Bai, Jinzhao; Cai, Yajie; Huang, Zhiyan; Gu, Yu‐Cheng; Huang, Nana; Sun, Rong; Zhang, Guimin; Liu, Runping

doi:10.1016/j.biopha.2022.113627

Cited by 19 publications

(13 citation statements)

References 49 publications

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“…67,68 Although Turicibacter 's precise role in constipation is still not entirely understood, Zhang et al 's research on the topic revealed that it may have a role in its etiology because of its negative associations with intestinal motility, the intestinal barrier, and the metabolism of SCFAs. 53 These were consistent with the results of this study. Consequently, the findings suggested a potential association between Akkermansia and Turicibacter constipation that requires further investigation.…”

Section: Discussionsupporting

confidence: 93%

“…5D), in line with previous studies. 53 The genus level of the intestinal microbiota was examined to look for variations between groups. Intestinal bacteria in all groups included a disproportionately high percentage of Muribaculaceae, Bacteroides, Akkermansia, Muribaculum, Lachnospiraceae_NK4A136_group, Alistipes, Blautia and Roseburia (Fig.…”

Section: Food and Function Papermentioning

confidence: 99%

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Xylooligosaccharides from corn cobs alleviate loperamide-induced constipation in mice via modulation of gut microbiota and SCFA metabolism

Song,

Guo,

Sun

et al. 2023

Food Funct.

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Section: Discussionsupporting

confidence: 93%

Section: Food and Function Papermentioning

confidence: 99%

Xylooligosaccharides from corn cobs alleviate loperamide-induced constipation in mice via modulation of gut microbiota and SCFA metabolism

Song,

Guo,

Sun

et al. 2023

Food Funct.

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“…The main side effects of loperamide are bloating and constipation, and its cardiovascular toxicity has also been reported [ 25 ]. In this study, loperamide was used to establish a constipation mouse model as in the previous studies [ 26 , 27 , 28 ] with some modifications. The fecal water content and fecal morphology ( Figure 1 B,C) are associated parameters by which to evaluate the function of the GI tract.…”

Section: Resultsmentioning

confidence: 99%

Prevention of Loperamide-Induced Constipation in Mice and Alteration of 5-Hydroxytryotamine Signaling by Ligilactobacillus salivarius Li01

et al. 2022

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Although Ligilactobacillus salivarius Li01 (Li01) has shown much promise in preventing multiple gastrointestinal diseases, the potential of the probiotic in alleviating constipation and the related mechanisms remain unclear. In this study, the effects of Li01 were evaluated in a loperamide-induced constipation mouse model. The results demonstrated that Li01 intervention can relieve constipation symptoms by improving water content, quantity, and morphology of feces and act as an intestinal barrier structure protector. Furthermore, Li01 can modulate gut motility (gastrointestinal transit rate), the fluid transit-associated expression of aquaporins, and the serum parameters vasoactive intestinal peptide, substance P, and somatostatin. Constipation significantly increased the levels of 5-hydroxytryotamine (5-HT) in serum (p < 0.01) and decreased the levels in the intestine (p < 0.001). Due to its function of elevating the expression of tryptophan hydroxylase 1, this was reversed after Li01 treatment. Li01 also promoted the expression of 5-HT receptor 3 and 4, indicating that the 5-HT signaling pathway may play a critical role in the mechanism by which Li01 alleviate constipation symptoms. Additionally, Li01 significantly altered the gut microbiota composition by enhancing the ratio of Firmicutes/Bacteroidetes and increasing the abundance of Rikenellaceae_RC9 genera. Based on the above results, Li01 may have the potential to effectively alleviate constipation by regulating the 5-HT pathway and alteration of the gut microbiota.

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“…We randomly divided the mice into three groups ( n = 5 per group): control group, constipation group (LOP), and LOP/D-Au NPs group. We administered the mice in the constipation group with loperamide hydrochloride (10 mg·kg –1 ·d –1 ) for 14 days of twice-daily oral gavage to induce constipation. , We simultaneously administered the mice in the LOP/D-Au NPs group with loperamide hydrochloride (10 mg·kg –1 ·d –1 ) and D-Au NPs (1700 μg·kg –1 ·d –1 ) for 14 days of twice-daily oral gavage. We administered the mice in the control group with the same volume of normal saline.…”

Section: Materials and Methodsmentioning

confidence: 99%

Ligand-Modified Gold Nanoparticles as Mitochondrial Modulators: Regulation of Intestinal Barrier and Therapy for Constipation

et al. 2023

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Intestinal metabolism-related diseases, such as constipation, inflammatory bowel disease, irritable bowel syndrome, and colorectal cancer, could be associated with the dysfunction of intestinal mitochondria. The mitochondria of intestinal epithelial cells are of great significance for promoting intestinal motility and maintaining intestinal metabolism. It is necessary for the prophylaxis and therapy of intestinal metabolism-related diseases to improve mitochondrial function. We investigated the effect of 4,6-diamino-2-pyrimidinethiol-modified gold nanoparticles (D-Au NPs) on intestinal mitochondria and studied the regulatory role of D-Au NPs on mitochondria metabolism-related disease. D-Au NPs improved the antioxidation capability of mitochondria, regulated the mitochondrial metabolism, and maintained intestinal cellular homeostasis via the activation of AMPK and regulation of PGC-1α with its downstream signaling (UCP2 and DRP1), enhancing the intestinal mechanical barrier. D-Au NPs improved the intestinal mitochondrial function to intervene in the emergence of constipation, which could help develop drugs to treat and prevent mitochondrial metabolism-related diseases. Our findings provided an in-depth understanding of the mitochondrial effects of Au NPs for improving human intestinal barriers.

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Shouhui Tongbian Capsule ameliorates constipation via gut microbiota-5-HT-intestinal motility axis

Cited by 19 publications

References 49 publications

Xylooligosaccharides from corn cobs alleviate loperamide-induced constipation in mice via modulation of gut microbiota and SCFA metabolism

Xylooligosaccharides from corn cobs alleviate loperamide-induced constipation in mice via modulation of gut microbiota and SCFA metabolism

Prevention of Loperamide-Induced Constipation in Mice and Alteration of 5-Hydroxytryotamine Signaling by Ligilactobacillus salivarius Li01

Ligand-Modified Gold Nanoparticles as Mitochondrial Modulators: Regulation of Intestinal Barrier and Therapy for Constipation

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