Should Administration of Coenzyme Q10 Be Recommended to Patients with Congestive Heart Failure?

Mitochondrial Pharmacology: Its Future Is Now

“…These have been classified as mitochondria‐targeted drugs, untargeted mitochondrial agents, and drugs acting on the translation of mitochondrial genes 11 . CoQ 10 has been advocated as mitochondria‐targeted therapy for secondary mitochondrial disorders, but properly designed studies have not been conducted to confirm its utility, even in treating patients with statin‐induced myopathy, as pointed out in this issue by Reidenberg 18 . Mortensen and Mortensen 19 also concede that there remains controversy concerning CoQ 10 's use in treating mitochondrial dysfunction resulting from congestive heart failure, although increasing evidence supports its use in this setting.…”