Should Brazilian patients with chronic hepatitis C virus infection be vaccinated against hepatitis A virus?

Villar, Lívia Melo; Melo, Maria Mabel Monte de; Calado, I.A.; Almeida, Adílson José de; Lampe, Elisabeth; Gaspar, Ana

doi:10.1111/j.1440-1746.2008.05575.x

Cited by 6 publications

(4 citation statements)

References 31 publications

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“…For this reason, authors of this study recommend anti-HAV testing before vaccination against HAV as a cost-effective strategy. 18 However, these results are higher than those observed in patients with HCV infection (mean age of 44.8 years), in the city of Rio de Janeiro (86%), leading authors of this other study to recommend implementation of hepatitis A vaccination for this population. 19 Thus, despite the observed changes in the HA epidemiology from high to intermediate endemicity in the Southeastern Brazil, the high seroprevalence of anti-HAV antibodies in adult patients with LC observed in the present study shows that routine HA vaccination could not be implemented for this patients.…”

Section: Discussioncontrasting

confidence: 47%

Seroprevalence of hepatitis A immunity among brazilian adult patients with liver cirrhosis: is HAV vaccination necessary?

Oliveira¹,

Comácio²,

Santos³

2011

Braz J Infect Dis

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BACKGROUND: Patients with chronic liver disease have a higher risk of fulminant hepatitis when infected with hepatitis A virus, and vaccination of these patients against such infection is recommended. In Brazil, mainly in the South and Southeast regions, the epidemiology of hepatitis A (HA) has shifted from high to intermediate endemicity, which would have implication on policy of HA vaccination for these populations. OBJECTIVE: To verify the prevalence of HA immunity in adult patients with liver cirrhosis (LC), in Uberlândia MG, a city of Southeastern Brazil. METHODS: Between December 2005 and December 2006, 106 patients with LC were consecutively evaluated. In addition, 75 individuals without LC or alcoholism were evaluated (control group - CG). RESULTS: Total anti-HAV (ELISA methods) was positive in 104 (98.1%) patients with LC (82 men, 24 women; mean age, 53.3 ± 11.9 years) and in 74 (98.7%) individuals of the CG (55 men, 20 women; mean age, 47 ± 11.6 years), p > 0.05. CONCLUSIONS: For patients with chronic liver disease, in the geographic regions and age groups evaluated, routine vaccination against hepatitis A is not recommended. Moreover, the serum determination of total anti-HAV, used to assess immunity, is five times cheaper than vaccination against hepatitis A and, for this reason, should precede vaccination

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Section: Discussioncontrasting

confidence: 47%

Seroprevalence of hepatitis A immunity among brazilian adult patients with liver cirrhosis: is HAV vaccination necessary?

Oliveira¹,

Comácio²,

Santos³

2011

Braz J Infect Dis

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“…At present, although direct-acting antivirals against HCV can lead to a higher sustained virological response with less adverse events, no effective HCV vaccines are available. Thus, HAV vaccination should be considered for HCV-infected patients, especially those with cirrhosis or advanced fibrosis [ 81 , 82 , 83 , 84 , 85 , 86 , 87 , 88 ].…”

Section: Coinfection Of Hav With Hcvmentioning

confidence: 99%

“…HAV vaccination may be important for patients with chronic liver diseases, especially those with cirrhosis [ 81 , 82 , 83 , 84 , 85 , 86 , 87 , 88 ]. While a universal vaccination program against HAV seems to be the most effective solution for the prevention of HAV infection, it may be difficult to carry out this program worldwide due to the high costs of HAV vaccine production and its low effectiveness in certain countries in which the infection is endemic [ 88 , 95 ].…”

Section: Prevention Of Hav Infection In Patients With Chronic LIVmentioning

confidence: 99%

Co-Occurrence of Hepatitis A Infection and Chronic Liver Disease

Sasaki

Masuzaki

Takahashi

et al. 2020

IJMS

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Hepatitis A virus (HAV) infection occasionally leads to a critical condition in patients with or without chronic liver diseases. Acute-on-chronic liver disease includes acute-on-chronic liver failure (ACLF) and non-ACLF. In this review, we searched the literature concerning the association between HAV infection and chronic liver diseases in PubMed. Chronic liver diseases, such as metabolic associated fatty liver disease and alcoholic liver disease, coinfection with other viruses, and host genetic factors may be associated with severe hepatitis A. It is important to understand these conditions and mechanisms. There may be no etiological correlation between liver failure and HAV infection, but there is an association between the level of chronic liver damage and the severity of acute-on-chronic liver disease. While the application of an HAV vaccination is important for preventing HAV infection, the development of antivirals against HAV may be important for preventing the development of ACLF with HAV infection as an acute insult. The latter is all the more urgent given that the lives of patients with HAV infection and a chronic liver disease of another etiology may be at immediate risk.

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“…No entanto, a superinfecção pelo VHA em pacientes com doenças crônicas do fígado, incluindo pacientes com hepatite crônica causada pelo VHC, está associada com um alto risco de hepatite fulminante e óbito (ROWE I.A. et al, 2012, CHO H. C. et al, 2011, VILLAR M. L. et al, 2008, SHIM M. et al, 2005, SAAB S., et al, 2005, VENTO S. et al, 1998.…”

Section: T; Morgan T R 2006)unclassified

Prevalência de marcadores sorológicos das hepatites A e B em pacientes com hepatite C crônica atendidos no ambulatório de hepatites do serviço de Gastroenterologia Clínica do Hospital das Clínicas da Faculdade de Medicina da Universidade

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Should Brazilian patients with chronic hepatitis C virus infection be vaccinated against hepatitis A virus?

Cited by 6 publications

References 31 publications

Seroprevalence of hepatitis A immunity among brazilian adult patients with liver cirrhosis: is HAV vaccination necessary?

Seroprevalence of hepatitis A immunity among brazilian adult patients with liver cirrhosis: is HAV vaccination necessary?

Co-Occurrence of Hepatitis A Infection and Chronic Liver Disease

Prevalência de marcadores sorológicos das hepatites A e B em pacientes com hepatite C crônica atendidos no ambulatório de hepatites do serviço de Gastroenterologia Clínica do Hospital das Clínicas da Faculdade de Medicina da Universidade

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