This article explores the practice of Christian mission in the developing field of global health care. First, the definition and context of global health is discussed. Second, the history of medical missions is traced, from their origins in biblical healing, through traditional medical missions in the 19th century, to today’s global health-care paradigm. Third, the situation of Christian medical mission today is described – in hospitals and non-governmental organisations, and in partnerships with governments and other secular agencies delivering health care. Two key challenges for Christian mission in the global health-care context are then discussed: increasing distance from individuals and increasing pressure not to evangelise. The reasons for evangelicals sometimes appearing to succumb to this latter pressure are considered. Finally, an attempt to resolve this tension is made in the context of Christian calling and the task all Christians have to make disciples, whatever their role in life.