Should High Dose Chemotherapy
with, or without. Autologous Bone
Marrow Transplant Be Included in the
Primary Treatment of Testicular
Cancer? Round Table Discussion

Km, Grigor; Schmoll, H.-J.

doi:10.1159/000474600

Cited by 3 publications

(1 citation statement)

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“…Renal tubular injury frequently occurs under several circumstances, including therapy with aminoglycosides, cis-platinum and heavy metals, and in patients with reflux nephropathy. Although cis-platinum causes renal tubular injury, multi-drug chemotherapy with cis-platinum is a very popular treatment in several kinds of malignancies [10][11][12], including testicular cancer [13]. In the treatment of testicular cancer, higher doses of cis-platinum are used compared with other types of cancers; renal toxicity is therefore one of the important ratelimiting factors [14].…”

Section: Introductionmentioning

confidence: 99%

Urinary Endothelin-1-Like Immunoreactivity in Young Male Patients with Testicular Cancer Treated by CIS-Platinum: Comparison with other Urinary Parameters

et al. 1994

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1. Urinary excretion of endothelin-1-like immunoreactivity and urinary excretion of other parameters (beta 2-microglobulin, N-acetyl-beta-D-glucosaminidase and microalbumin) were measured before, within 1 week after and 2 weeks after the administration of cis-platinum in five young male patients with testicular cancer (mean age 33.0 years) and were compared. 2. Urinary endothelin-1-like immunoreactivity/creatinine during, 1 week after, and 2 weeks after cis-platinum treatment was significantly higher than before cis-platinum. There was no difference in urinary endothelin-1-like immunoreactivity/creatinine during, 1 week after and 2 weeks after cis-platinum. 3. Among the four parameters, urinary endothelin-1-like immunoreactivity/creatinine showed the highest level after cis-platinum treatment. Urinary beta 2-microglobulin/creatinine most rapidly returned to normal levels after cis-platinum. 4. Although urinary endothelin-1-like immunoreactivity/creatinine did not show any significant correlations with urinary N-acetyl-beta-D-glucosaminidase (r = 0.291, not significant) or urinary microalbumin/creatinine (r = 0.076, not significant), it showed a significant correlation with urinary beta 2-microglobulin/creatinine (r = 0.475, P < 0.05). 5. These results suggest that endothelin-1 may be a sensitive urinary parameter in detecting cis-platinum-induced renal tubular injury.

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Section: Introductionmentioning

confidence: 99%