Should individuals use influenza vaccine effectiveness studies to inform their decision to get vaccinated?

Zhao, Linlu; Stirling, R. Ferguson; Young, Kelsey

doi:10.14745/ccdr.v45i06a02

Cited by 3 publications

(3 citation statements)

References 4 publications

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“…More generally, it is still unclear whether the expected vaccine effectiveness should be provided to laypeople. Zhao et al [43] have stated that "vaccine effectiveness studies are designed to inform public health decisions rather than for individual decision-making" and "an individual's decision to get vaccinated should be primarily informed by their risk of influenza illness and their risk of transmitting influenza to vulnerable people". We, however, believe that anticipated suboptimal (which varies substantially by season, location, age group, and average 40-60% [44]) IV effectiveness should be openly disclosed by healthcare providers.…”

Section: Discussionmentioning

confidence: 99%

Changes in Attitudes and Beliefs Concerning Vaccination and Influenza Vaccines between the First and Second COVID-19 Pandemic Waves: A Longitudinal Study

Domnich

Grassi²,

Fallani

et al. 2021

Vaccines

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Perceptions of the risks of vaccine-preventable diseases and preventive behaviors change over time. The ongoing COVID-19 pandemic may have modified laypeople’s attitudes towards routine vaccinations. In this longitudinal study, we aimed to assess changes in attitudes and beliefs concerning (influenza) vaccines between the first and second COVID-19 pandemic waves. A total of 1979 participants completed both 2020 and 2021 surveys. After one year, more interviewees agreed that vaccines were fundamental and should be mandatory (77.3% vs. 75.0%). Analogously, willingness to undergo influenza vaccination increased (p < 0.001) from 44.1% to 48.6%. This increase was seen in subjects aged ≥35 years. Previous influenza vaccinations, receipt of a COVID-19 vaccine, positive attitudes towards (influenza) vaccination, male sex, and older age were the main correlates of willingness to receive the 2021/22 influenza vaccine. Totals of 12.6% and 11.8% had no intention to receive the next seasonal influenza and COVID-19 vaccines, respectively. Most respondents favored a hypothetical combined influenza/COVID-19 vaccine (73.7%) or influenza and COVID-19 vaccine co-administration (67.5%). In Italy, influenza and COVID-19 vaccination hesitancy and refusal are common. Effective public health strategies to pursue higher uptake of both vaccines are urgently needed.

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Section: Discussionmentioning

confidence: 99%

Changes in Attitudes and Beliefs Concerning Vaccination and Influenza Vaccines between the First and Second COVID-19 Pandemic Waves: A Longitudinal Study

Domnich

Grassi²,

Fallani

et al. 2021

Vaccines

View full text Add to dashboard Cite

show abstract

“…On the other side, acknowledgement that variable influenza vaccine effectiveness estimates may change the decision-making process by both vaccinating HCPs and patients, and the question of whether or not to communicate vaccine effectiveness data to patients is debatable. In this regard, Zhao et al [ 53 ] have claimed that “vaccine effectiveness studies are designed to inform public health decisions rather than for individual decision-making” and “an individual’s decision to get vaccinated should be primarily informed by their risk of influenza illness and their risk of transmitting influenza to vulnerable people”. However, we believe that in the web 2.0 era, when the patient–HCP relationship paradigm has been changing continuously, a vaccinating HCP should inform the patient about expected levels of vaccine effectiveness.…”

Section: Discussionmentioning

confidence: 99%

Attitudes and Beliefs on Influenza Vaccination during the COVID-19 Pandemic: Results from a Representative Italian Survey

Domnich¹,

Cambiaggi²,

Vasco³

et al. 2020

Vaccines

107

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The last 2019/20 northern hemisphere influenza season overlapped with the first wave of coronavirus disease 2019 (COVID-19) pandemic. Italy was the first western country where severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spread to a significant extent. In this representative cross-sectional survey, we aimed to describe some opinions and attitudes of the Italian general population towards both influenza vaccination and the COVID-19 pandemic, and to identify potential modifiers of the decision-making process regarding the uptake of the 2020/21 influenza vaccine. A total of 2543 responses were analyzed. Although most (74.8%) participants valued influenza vaccination positively and declared that it should be mandatory, some misconceptions around influenza persist. The general practitioner was the main source of trusted information on influenza vaccines, while social networks were judged to be the least reliable. Younger and less affluent individuals, subjects not vaccinated in the previous season, and those living in smaller communities showed lower odds of receiving the 2020/21 season influenza vaccination. However, the COVID-19 pandemic may have positively influenced the propensity of being vaccinated against 2020/21 seasonal influenza. In order to increase influenza vaccination coverage rates multidisciplinary targeted interventions are needed. The role of general practitioners remains crucial in increasing influenza vaccine awareness and acceptance by effective counselling.

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“…For example, VE in the elderly population is reduced because of lower seroconversion rates that arise due to poorer immunological response to vaccination [ 90 ]. How well an individual responds to a vaccine may also be determined by underlying health conditions [ 91 ]. The observed higher pooled adjusted VE for studies that included age but not medical conditions compared with those that included both age and medical conditions among adjusted covariates in studies is in line with expectations, as adjusting for both age and medical conditions is likely to diminish VE compared with adjusting for age.…”

Section: Discussionmentioning

confidence: 99%

Variations in Seasonal Influenza Vaccine Effectiveness due to Study Characteristics: A Systematic Review and Meta-analysis of Test-Negative Design Studies

Okoli

Racovitan

Righolt

et al. 2020

Open Forum Infectious Diseases

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Background Study characteristics influence vaccine effectiveness (VE) estimation. We examined the influence of some of these on seasonal influenza VE estimates from test-negative design (TND) studies. Methods We systematically searched bibliographic databases and websites for full-text publications of TND studies on VE against laboratory-confirmed seasonal influenza in outpatients after the 2009 pandemic influenza. We followed the Cochrane Handbook for Systematic Reviews of Interventions guidelines. We examined influence of source of vaccination information, respiratory specimen swab time, and covariate adjustment on VE. We calculated pooled adjusted VE against H1N1 and H3N2 influenza subtypes, influenza B, and all influenza using an inverse-variance random-effects model. Results We included 70 full-text articles. Pooled VE against H1N1 and H3N2 influenza subtypes, influenza B, and all influenza was higher for studies that used self-reported vaccination than for those that used medical records. Pooled VE was higher with respiratory specimen collection within ≤7 days vs ≤4 days of symptom onset, but the opposite was observed for H1N1. Pooled VE was higher for studies that adjusted for age but not for medical conditions compared with those that adjusted for both. There was, however, a lack of statistical significance in almost all differences in pooled VE between compared groups. Conclusions The available evidence is not strong enough to conclude that influenza VE from TND studies varies by source of vaccination information, respiratory specimen swab time, or adjustment for age/medical conditions. The evidence is, however, indicative that these factors ought to be considered while designing or evaluating TND studies of influenza VE.

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Should individuals use influenza vaccine effectiveness studies to inform their decision to get vaccinated?

Cited by 3 publications

References 4 publications

Changes in Attitudes and Beliefs Concerning Vaccination and Influenza Vaccines between the First and Second COVID-19 Pandemic Waves: A Longitudinal Study

Changes in Attitudes and Beliefs Concerning Vaccination and Influenza Vaccines between the First and Second COVID-19 Pandemic Waves: A Longitudinal Study

Attitudes and Beliefs on Influenza Vaccination during the COVID-19 Pandemic: Results from a Representative Italian Survey

Variations in Seasonal Influenza Vaccine Effectiveness due to Study Characteristics: A Systematic Review and Meta-analysis of Test-Negative Design Studies

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