Should Loss of Appetite Be Palliated in Patients with Advanced Cancer?

Ehret, Christopher; Jatoi, Aminah

doi:10.1007/s11864-021-00829-0

Cited by 7 publications

(4 citation statements)

References 28 publications

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“…The most prevalent sign of NIS during chemotherapy in this study is lossing of appetite. Previous research has shown that patients with advanced malignancies are more likely to experience appetite loss [15], which is typically brought on by tumor growth, the side effects of treatment, and psychosocial stress associated with the tumor [16,17]. For instance, 10,753 individuals with advanced pancreatic cancer were investigated by Mavros et al[18].…”

Section: Discussionmentioning

confidence: 99%

The experience of nutrition impact symptoms during chemotherapy for lung cancer patients : A qualitative study

Zhu,

Ding,

Shi

et al. 2023

Preprint

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Purpose This study comprehend the perspective of lung cancer patients who encounter nutrition impact symptoms during chemotherapy and investigate how these symptoms manifest in lung cancer patients and the physical and psychological impacts they have.Method Semi-structured interviews with 31 lung cancer patients from a hospital in Jiangsu Province, China, were conducted using a phenomenological technique. The interviews were taped, verbatim and sentence-for-sentence, and then subjected to Colaizzi's seven-step analysis procedure.Results The data analysis produced the following two major themes: "nutrition impact symptoms" and "the psychosocial effects of nutrition impact symptoms." Patients with lung cancer who underwent chemotherapy frequently experienced mouth ulcers, xerostomia, and lack of appetite. "Lose the pleasure of eating," "persistent depression," "feeling of helplessness," and "social restriction" are among the sub-themes under the second major theme.Conclusion This study emphasizes the negative impacts of nutrition on the physical and mental aspects of lung cancer patients' chemo-induced symptoms. Lung cancer patients continue to encounter physical discomfort, unfavorable mood swings, and even social limitations throughout chemotherapy as a result of nutrition-related illnesses. Patients with lung cancer may experience long-lasting nutrition impact symptoms during the early stages of chemotherapy, which can have a significant impact on quality of life and the outcome of the subsequent course of treatment.

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Section: Discussionmentioning

confidence: 99%

The experience of nutrition impact symptoms during chemotherapy for lung cancer patients : A qualitative study

Zhu,

Ding,

Shi

et al. 2023

Preprint

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“…A limitation in this study is that we did not stratify the data by cancer type to explore appetite by specific cancer types, as the cohort was assessed as too small. However, loss of appetite is a major symptom in advanced cancer, where patients diagnosed with some cancer types, such as cancer in pancreas, are at a heightened risk [ 52 , 53 ]. Suggested future studies exploring loss of appetite in specific cancer types would contribute valuable knowledge to this field.…”

Section: Discussionmentioning

confidence: 99%

Appetite and its association with mortality in patients with advanced cancer – a Post-hoc Analysis from the Palliative D-study

Goodrose-Flores,

Bonn,

Klasson

et al. 2023

BMC Palliat Care

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Background Loss of appetite is a common nutrition symptom in patients with cancer. Understanding the trajectory of appetite could be of clinical use for prognostication in palliative cancer care. Our primary aim was to explore the association between self-assessed appetite and mortality in patients suffering from advanced cancer. Secondary aims included the relation between fatigue, albumin levels and CRP/albumin ratio and mortality. We also aimed to study potential sex-differences in the associations. Methods Post-hoc analyses were performed using data from the Palliative D-study comprising 530 patients with cancer admitted to palliative care. Appetite and fatigue were assessed with the Edmonton Symptom Assessment System (ESAS). Cox proportional hazards models were used to calculate Hazard ratios (HR) with 95% confidence intervals (CI) for exposures of appetite, fatigue, albumin and CRP/albumin ratio, and time from study inclusion to death or censoring. Analyses were also performed stratified by sex. Results The follow-up time ranged between 7 to 1420 days. Moderate and poor appetite were significantly associated with a higher mortality rate compared to reporting a good appetite; HR 1.44 (95%CI: 1.16–1.79) and HR 1.78 (95%CI: 1.39–2.29), respectively. A higher mortality rate was also seen among participants reporting severe fatigue compared to those reporting no fatigue; HR 1.84 (95%CI:1.43–2.36). Participants with low albumin levels (< 25 g/L) and those in the highest tertile of CRP/albumin ratio, had higher mortality rates, HR 5.35 (95%CI:3.75–7.63) and HR 2.66 (95%CI:212–3.35), compared to participants with high albumin levels (> 36 g/L) and those in lowest tertile of CRP/albumin ratio. These associations were more pronounced in men than in women. Conclusion Poor appetite, severe fatigue, low albumin level and a high CRP/albumin ratio were associated with increased mortality rates among patients with advanced cancer. All these variables might be clinically useful for prognostication in palliative cancer care. Trial registration Clinicaltrial.gov. Identifier: NCT03038516;31, January 2017.

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“…Loss of appetite is also a prevalent symptom in advanced cancer patients [ 5 ] and has been related to worse quality of life, anxiety, and depression [ 8 –[ 9 , 11 ]– 12 ]. Ehret et al [ 33 ], in their article “Should Loss of Appetite Be Palliated in Patients with Advanced Cancer?” I concluded that the decision on the management of this symptom should be based on the expanded discussion among health professionals, patients, and family members, to assess how important appetite is for patients and their families. The management of this symptom will benefit from pharmacological drugs and nutritional and psychological follow-up [ 33 ].…”

Section: Discussionmentioning

confidence: 99%

Anxiety and depression disorders in oncological patients under palliative care at a hospital service: a cross-sectional study

et al. 2023

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Background This study aimed to evaluate the risk and protective factors associated with anxiety and depression symptoms in cancer patients at an advanced stage of cancer. Methods A cross-sectional study was conducted on patients with advanced cancer who were receiving palliative care. Cancer patients aged 18 years or older, with preserved cognitive function who completed the questionnaires were eligible. The questionnaires of Hospital Anxiety and Depression Scale (HADS) and health related of quality of life questionnaire; the European Organization for Research and Treatment of Cancer (EORTC-C30) were applied. Outcome variables were the depression and anxiety symptoms of cancer patients under palliative care, according to the answers to the 14 items that make up the HADS Scale. The analysis used the R software, version 4.2.0. Results Seventy cancer patients with advanced cancer were included. The colon was the most common neoplastic diagnostic (20%), followed by breast (12.9%) and lung (10%). The prevalence of depression was 44.3%, 25.7% anxiety and 52.9% had both symptoms. Patients with a high level of functionality had a lower chance of anxiety (OR = 0.80;p = 0.025), depression (OR = 0.82; p = 0.007), and anxiety and depression (OR = 0.82p = 0.008). We observed a lower chance of depression and depression/anxiety who showed a high level of Overall Performance. Three symptoms increased the chance of depression/anxiety: nausea/vomiting (p = 0.019), fatigue (0.031), loss of appetite (0.048). Conclusion This study found high prevalence of anxiety and depression.Better quality of life and functionality were negatively associated with these outcomes. Examining the patient’s functions will assist the clinician in alleviating symptoms of anxiety and depression, giving cancer patients in palliative care more dignity. Trial registration Not applicable.

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Should Loss of Appetite Be Palliated in Patients with Advanced Cancer?

Cited by 7 publications

References 28 publications

The experience of nutrition impact symptoms during chemotherapy for lung cancer patients : A qualitative study

The experience of nutrition impact symptoms during chemotherapy for lung cancer patients : A qualitative study

Appetite and its association with mortality in patients with advanced cancer – a Post-hoc Analysis from the Palliative D-study

Anxiety and depression disorders in oncological patients under palliative care at a hospital service: a cross-sectional study

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