Should meta-analysts search Embase in addition to Medline?

Sampson, Margaret; Barrowman, Nicholas; Moher, David; Klassen, Terry P; Pham, Ba’; Platt, Robert W.; John, Philip D. St.; Viola, Raymond; Raina, Parminder

doi:10.1016/s0895-4356(03)00110-0

Cited by 144 publications

(87 citation statements)

References 23 publications

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“…A manual search of Spine, European Spine Journal, and the American and British versions of Journal of Bone and Joint Surgery, as well as the reference lists of the selected studies was conducted to identify further articles. Though Embase was not accessible, we assumed that there would be few additional references when a comprehensive search in the abovementioned databases combined with a hand search was conducted (35).…”

Section: Search Strategy and Inclusion/exclusion Criteriamentioning

confidence: 99%

Can posterior dynamic stabilization reduce the risk of adjacent segment deterioration?

Zhou¹,

Xia²,

Zhao³

et al. 2012

Turkish Neurosurgery

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AIm:The aim of this study was to systematically review the relevant literature to develop a benchmark for the incidence of adjacent segment degeneration (ASDeg) and adjacent segment disease (ASDis) following the posterior dynamic stabilization (PDS) procedure and to investigate whether conclusions can be made with regard to the isolated PDS procedure in reducing the risk of ASDeg and ASDis compared with fusion, and with regard to the role of additional PDS devices implanted adjacent to fusion in protecting from ASDeg and ASDis caused by the neighboring fusion. mAteRIAl and methods:We retrieved electronic databases of Medline, Ovid and Cochrane Central Registry of Controlled Trials, combined with a supplemental hand search. Thirty-one articles met our inclusion criteria. Results:The pooled incidence of ASDeg and ASDis following PDS procedure was 16.4% and 5.5% respectively. Data from comparative studies showed a significantly lower incidence of ASDeg and nonsignificantly lower incidence of ASDis following PDS than following fusion surgery. Further, the additional PDS devices implanted adjacent to fusion could significantly reduce the risk of ASDeg and nonsignificantly decrease that of ASDis caused by fusion. BulGulAR: PDS işleminden sonra ASDeg ve ASDis'in birleştirilmiş insidansı sırasıyla %16,4 ve %5,5 bulundu. Karşılaştırmalı çalışmalardan veriler PDS'den sonra füzyon cerrahisine göre önemli ölçüde daha düşük ASDeg insidansı ve önemli olmayan ölçüde daha düşük ASDis insidansı gösterdi. Ayrıca füzyona komşu implante edilen ek PDS cihazları füzyonun neden olduğu ASDeg riskini önemli ölçüde ve ASDis riskini önemli olmayan ölçüde azaltabiliyordu. sonuÇ: Bu sonuçlar PDS işleminin ASDeg ve ASDis durumlarına karşı koruma açısından relatif başarısına işaret etti. ConClusIon

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Section: Search Strategy and Inclusion/exclusion Criteriamentioning

confidence: 99%

Can posterior dynamic stabilization reduce the risk of adjacent segment deterioration?

Zhou¹,

Xia²,

Zhao³

et al. 2012

Turkish Neurosurgery

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“…It is not clear, however, whether a search limited to Medline might bias estimates of treatment benefit [13], provided the rest of the search is comprehensive. From our results in asymptomatic patients, the diagnostic OR is very little or marginally influenced by the number of databases searched.…”

Section: Resultsmentioning

confidence: 99%

“…Few authors have shown that searching Embase and Pascal Biomed could complement Medline in the field of randomized clinical trials [8][9][10][11][12][13]. Topfer [9] has compared literature searches for devices in Embase and Medline, however, all devices included in this study had therapeutic uses.…”

Section: Introductionmentioning

confidence: 99%

Literature search parameters marginally improved the pooled estimate accuracy for ultrasound in detecting deep venous thrombosis

Kassaï¹,

Sonié²,

Shah³

et al. 2006

Journal of Clinical Epidemiology

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Background and Objectives-Data collection remains of utmost importance to avoid publication bias in systematic reviews. Our objectives were to compare search strategies with and without methodological terms in Medline, to find out how other databases complement Medline, and how these strategies affect the pooled estimates of the accuracy.Study Design and Setting-A study was eligible if it prospectively compared ultrasound to venography for the diagnosis of deep venous thrombosis in the lower limbs. All relevant articles found with all databases, searched from 1966 through 2003, constitute the reference standard. Sensitivity was defined as the proportion of relevant studies found by Medline searches divided by the total number of articles in the reference standard.Results-Of a total of 1,473 citations, 237 abstracts were included. The sensitivity of strategies without methodological terms was higher (96%) than those with (95%, 76%, and 95%). Searches of multiple databases found seven articles not found with Medline. Searches of congress proceedings (International Society of Thrombosis and Haemostasis) found three abstracts not published in full. The diagnostic odds ratio OR was 5.66 (95% confidence interval CI = 4.84-6.48) when multiple databases were searched and 5.57 (95% CI = 3.49-7.65) when only English-language articles in Medline were identified.Conclusion-Medline searches combining free text and MeSH terms were more sensitive. Single Medline search affects only marginally the pooled estimate accuracy.

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“…We had no access to Embase and assumed it would provide few additional references if a comprehensive retrieval was performed in the aforementioned databases. 39 The search strategy combined the terms clazosentan, endothelin receptor antagonists, endothelins crossed with subarachnoid hemorrhage, intracranial aneurysm, or intracranial vasospasm. We restricted the search to human studies and clinical trials.…”

Section: Literature Searchmentioning

confidence: 99%

Dissociation of vasospasm-related morbidity and outcomes in patients with aneurysmal subarachnoid hemorrhage treated with clazosentan: a meta-analysis of randomized controlled trials

Shen¹,

Pan²,

Fan³

et al. 2013

JNS

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Object Clazosentan therapy after aneurysmal subarachnoid hemorrhage (SAH) has been found to be effective in reducing the incidence of vasospasm in randomized controlled trials. However, while vasospasm-related morbidity, including delayed ischemic neurological deficits (DINDs) and delayed cerebral infarctions, was consistently decreased, statistical significance was not demonstrated and outcomes were not affected by clazosentan treatment. The objective of this meta-analysis was to determine whether clazosentan treatment after aneurysmal SAH significantly reduced the incidence of DINDs and delayed cerebral infarctions and improved outcomes. Methods All randomized controlled trials investigating the effect of clazosentan were retrieved via searches with sensitive and specific terms. Six variables were abstracted after the assessment of the methodological quality of the trials. Analyses were performed following the method guidelines of the Cochrane Back Review Group. Results Four randomized, placebo-controlled trials met eligibility criteria, enrolling a total of 2181 patients. The meta-analysis demonstrated a significant decrease in the incidence of DINDs (relative risk [RR] 0.76 [95% CI 0.62–0.92]) and delayed cerebral infarction (RR 0.79 [95% CI 0.63–1.00]) in patients treated with clazosentan after aneurysmal SAH. However, this treatment regimen was not shown to outcomes including functional outcomes measured by Glasgow Outcome Scale-Extended (RR 1.12 [95% CI 0.96–1.30]) or mortality (RR 1.02 [95%CI 0.70–1.49]). Adverse events, including pulmonary complications, anemia, and hypotension, were all significantly increased in patients who received clazosentan therapy. Conclusions The results of the present meta-analysis show that treatment with clazosentan after aneurysmal SAH significantly reduced the incidence of the vasospasm-related DINDs and delayed cerebral infarctions, but did not improve poor neurological outcomes in patients with aneurysmal SAH. Further study is required to elucidate the dissociation between vasospasm-related morbidity and outcomes.

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Should meta-analysts search Embase in addition to Medline?

Cited by 144 publications

References 23 publications

Can posterior dynamic stabilization reduce the risk of adjacent segment deterioration?

Can posterior dynamic stabilization reduce the risk of adjacent segment deterioration?

Literature search parameters marginally improved the pooled estimate accuracy for ultrasound in detecting deep venous thrombosis

Dissociation of vasospasm-related morbidity and outcomes in patients with aneurysmal subarachnoid hemorrhage treated with clazosentan: a meta-analysis of randomized controlled trials

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