Should Nevus Sebaceus of Jadassohn in Children be Excised? A Study of 757 Cases, and Literature Review

Santibanez-Gallerani, Alberto; Marshall, Diedre; Duarte, Ana M.; Melnick, Steven J.; Thaller, Seth R.

doi:10.1097/00001665-200309000-00010

Cited by 106 publications

(87 citation statements)

References 7 publications

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“…In 1895, the German dermatologist Josef Jadassohn histologically described sebaceous nevus as a congenital facial or scalp lesion with excess glandular skin structures [2]. Sebaceous nevus of Jadassohn is a hamartoma and is often referred to in early reports as an organoid nevus (involving all skin layers) [3], and may contain a variety of excess cutaneous structures including pilosebaceous, eccrine and apocrine elements.…”

Section: Discussionmentioning

confidence: 99%

Newborn with Sebaceous Nevus of Jadassohn Presenting as Exophytic Scalp Lesion

et al. 2008

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It is essential that various factors be considered when determining the differential diagnosis of congenital scalp lesions, including lesion size, appearance, intracranial extension, underlying medical condition and the embryological germ layer involved. We present the case of a newborn diagnosed as having a sebaceous nevus of Jadassohn scalp lesion. While a common congenital lesion, we describe the unusual presentation at birth as an exophytic nodular lesion. To our knowledge only one other case report of an exophytic congenital lesion has been published.

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Section: Discussionmentioning

confidence: 99%

Newborn with Sebaceous Nevus of Jadassohn Presenting as Exophytic Scalp Lesion

et al. 2008

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“…Serious complications can occur such as the development of a secondary neoplasm and a risk of malignant transformation (6,12,13). Th e rate of malignancy remains unknown due a lack of prospective studies, but current literature suggests that the most common secondary neoplasms seen within sebaceous nevi are benign syringocystadenoma papilliferum and trichoblastomas (6,(13)(14)(15)(16)). Th ere is a known association with basal cell carcinomas, which have been reported to occur in <1% of patients with sebaceous nevi (13)(14)(15).…”

Section: Discussionmentioning

confidence: 99%

“…Despite the overall risk of malignancy increasing with age, Rosen et al showed that basal cell carcinomas can develop within these lesions even prior to puberty and without signifi cant physical change (14). Conversely, Santibanez-Gallerani et al studied 757 cases of sebaceous nevi in children <16 years of age and found no basal cell carcinomas, thereby drawing the conclusion that prophylactic excision is not indicated (16). Determining workup and management of these lesions requires acknowledgment of these risks and consideration of patient goals.…”

Section: Discussionmentioning

confidence: 99%

Evaluation and Management of an Unusual Congenital Nevus

Kerwin

Menter

2017

Baylor University Medical Center Proceedings

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Abnormal findings on routine skin exams are common and can be a source of unnecessary medical workup if a clinician is unfamiliar with the finding. Sebaceous nevi are rare skin lesions that are most often benign but may be associated with a multiorgan syndrome or local skin cancer. Dermatologists and primary care physicians may encounter these on routine exams and thus must be comfortable with diagnosis and management. We present the clinical characteristics of a benign sebaceous nevus to help aid in diagnosis of these lesions and outline suggestions for appropriate management options.T he total body skin examination is one of the most common dermatologic visits and a common component of primary care visits. Examining the skin for potential malignancies can be taxing; therefore, effi cient evaluation is a necessity for high-volume clinics. Quick identifi cation of malignant features and confi dence in evaluating rare nevi is fundamental to effi ciency. We present a case describing the evaluation and management of a rare, unusual-appearing congenital nevus with neoplastic potential. CASE DESCRIPTIONA 52-year-old white woman presented to the dermatology clinic for a routine annual full-body skin exam and evaluation of a suspicious lesion she noticed on her posterior auricular skinfold. She was unsure how long the lesion had been present but believed it to be growing in size over the past 5 years. She denied pain, pruritus, bleeding, or drainage from the lesion and denied ophthalmologic defects, neurologic symptoms, skeletal deformities, or a personal history of skin cancers.Th e postauricular lesion was a linear, waxy, fl esh-and yellowcolored plaque that measured approximately 40 mm in length (Figure). No erythema or drainage was noted. On palpation, the lesion was fi rm and nonmobile, and sebum could not be expressed. No punctum was identifi ed. No other similar lesions were found on the remainder of the skin exam, only benign nevi and seborrheic keratoses.Th e lesion was determined to be a single sebaceous nevus based on texture, anatomic distribution, physical characteristics, and presence for more than 5 years. A biopsy was not performed as the lesion was not felt to have any signifi cant characteristics suggesting malignancy. Th e patient was counseled to observe the lesion for continued growth, change in texture, ulceration, or pruritus. Th e lesion was photographed to assist with monitoring it over time, with plans for yearly follow-ups. DISCUSSIONSebaceous glands are sebum-secreting glands located in the dermis of all hair-bearing skin and are associated with hair follicles and apocrine ducts (1). Hormones strongly aff ect the activity level of these glands; thus, at the time of puberty, sebum production increases. However, as an individual ages further, sebaceous glands become diff usely hyperplastic, sebum production decreases, and cell turnover and migration slow (2).

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“…2005 yılında 6264 çocuk arasında yapılan başka bir çalışmada 21 primer cilt tümörü arasında BCC insidansı %9.5 olarak belirtilmiştir (1). 2000 yılında yapılan başka bir çalışmada, 596 hastada (ortalama yaş:25.4) profilaktik nevus sebaseus eksizyonu sonrası 5 adet BCC tanı almıştır(%0.8) (9). 16 yaş altında sadece 6 hastada kitle içerisinde benign oluşum gözlenmiştir (9).…”

Section: Discussionunclassified

“…2000 yılında yapılan başka bir çalışmada, 596 hastada (ortalama yaş:25.4) profilaktik nevus sebaseus eksizyonu sonrası 5 adet BCC tanı almıştır(%0.8) (9). 16 yaş altında sadece 6 hastada kitle içerisinde benign oluşum gözlenmiştir (9). Premalign lezyon ve genetik hastalıklar dışında, çocukluk çağında BCC "de novo" olarak da ortaya çıkabilir.…”

Section: Discussionunclassified

Çocukluk Çaği Mali̇gn Deri̇ Tümörleri̇: Sebase Nevüs Zemi̇ni̇nde Geli̇şen Bazal Hücreli̇ Karsi̇nom

et al. 2015

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Basal cell carcinoma(BCC) is the most common skin tumor however it is very rare in childhood and usually associated with genetic syndromes. BCC can be sporadic very rarely in this age group but mostly there is a predisposing factor such as nevus sebaceous. In this case, 13 year-old girl developed a pigmented nodular lesion in the nevus sebaceous and referred to our clinic for excisional biopsy. The tumor was excised and pigmented basal cell carcinoma was diagnosed according to the pathology report. BCC in the childs may be overlooked due to the low prevalence so predisposing factors such as nevus sebaceous should be kept in mind and morphological changes seen in the lesion should be confirmed by biopsy. Keywords: Basal cell carsinoma; non-melanoma skin cancer; nevus sebaceous GİRİŞ BCC (Bazal hücreli karsinom), nonmelanom kutanöz kanserler içinde en sık görülen kanserdir. 6.-7. dekadda sıklığı artar, 40 yaş altı BCC prevalansı çok düşüktür (4,7). Çocukluk çağında çok nadir görülür ve sıklıkla genetik sendromlara eşlik eder (7). Kliniğimize başvuran saçlı derisinde mevcut olan sebase nevusünün büyümesi ve renk değişikliği göstermeye başlaması nedeniyle eksizyonel biyopsi yapılan ve biopsi sonucu BCC olarak raporlanan 13 yaşındaki kız hasta sunuldu ve literatür gözden geçirildi.VAKA 13 yaşındaki kız hasta, doğumdan itibaren saçlı derinin oksipital kısmında bulunan nodüler kitlenin büyümesi nedeniyle başvurdu. Hasta zamanla bu kitlenin sarımsı-pembe renge dönüştüğünü, son 2 yılda kitlenin boyutlarında artış olduğunu, yeni bir kitle oluştuğunu bildirdi. Yapılan fizik muayenede: Okspital bölgede yaklaşık olarak 4x2 cm boyutlarında, sınırları düzenli, eliptik şekilde, sarımsı-pembe papillomatöz lezyon ile bu lezyonun üst 1/3 kısmında yaklaşık 2x1 cm boyutlarında heterojen renkli, noduler kitle saptandı.

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Should Nevus Sebaceus of Jadassohn in Children be Excised? A Study of 757 Cases, and Literature Review

Cited by 106 publications

References 7 publications

Newborn with Sebaceous Nevus of Jadassohn Presenting as Exophytic Scalp Lesion

Newborn with Sebaceous Nevus of Jadassohn Presenting as Exophytic Scalp Lesion

Evaluation and Management of an Unusual Congenital Nevus

Çocukluk Çaği Mali̇gn Deri̇ Tümörleri̇: Sebase Nevüs Zemi̇ni̇nde Geli̇şen Bazal Hücreli̇ Karsi̇nom

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