Should Surgical Patients be Screened for Thrombophilia?

Wheeler, Hailey Britt; Walsh, Patrick C.

doi:10.1016/s0022-5347(05)68389-9

Cited by 1 publication

(2 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Thus, it is uncertain whether these conditions merit routine screening. It should be noted that laboratory thrombophilia screening is not a routine component of preoperative evaluations for other elective surgeries 20 …”

Section: Discussionmentioning

confidence: 99%

“…It should be noted that laboratory thrombophilia screening is not a routine component of preoperative evaluations for other elective surgeries. 20 F I G U R E 1 A proposed algorithm for thrombophilia screening among prospective live liver donors is outlined above. This algorithm seeks to reduce unnecessary testing by using personal and family history as a screening tool, and focusing thrombophilia testing only on those patients with concerning personal or family histories.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

The utility of thrombophilia and hematologic screening in live liver donation

Naymagon

Tremblay

Facciuto

et al. 2020

Clinical Transplantation

View full text Add to dashboard Cite

Background Most centers perform some degree of hematologic screening, including thrombophilia testing, on prospective live liver donors. The nature and extent of such screens are not standardized, and there is limited evidence regarding hematologic risk stratification. Methods and Results We present an experience of hematologic screening among prospective liver donors. Five‐hundred‐eightyfour patients were screened for liver donation between 1/2013 and 1/2020, of whom 156 (27%) proceeded to donor hepatectomy. Thirty‐three of 428 (8%) declined patients were excluded for hematologic indications. Hematologic indications were the 2nd most frequent medical indications for exclusion (trailing only hepatologic indications). The most common reason for hematologic exclusion was concern regarding thrombophilia. Nevertheless, 21 patients with evidence of possible thrombophilia proceeded to donor hepatectomy, and none incurred hematologic complications. Similarly, seven patients with screening findings concerning for increased bleeding risk (most often thrombocytopenia) underwent donor hepatectomy without hematologic complication. Three of 156 (2%) of patients who underwent donor hepatectomy incurred a hematologic complication (all thrombotic, none fatal). None of these patients had any evident hematologic risk factor on screening. Conclusion This study underscores the difficulty of hematologic risk stratification among prospective living donors, however, suggests that some patients with relatively mild risk factors may be safe for donation.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%