Should the high prevalence of sessile serrated lesions in patients aged below 50 years influence screening colonoscopy recommendations?

Ismail, Ali Galalah Mostafa; Lall, Vidit; Ayonrinde, Oyekoya T.

doi:10.1111/jgh.15511

Cited by 3 publications

(9 citation statements)

References 7 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…There is a reported increased incidence of CRC in the younger population in Australia 25 . As a result of this, there is discussion about commencing CRC screening at the younger age of 40 years for the population 26 . For patients aged between 40 and 49 inclusive, our study shows a low ADR of 13.1% and a high SLDR of 22.6%.…”

Section: Discussionmentioning

confidence: 60%

Quality of rural colonoscopy outperforms key performance indicators in a multi‐centre prospective clinical study

Watson

Maddern

et al. 2022

ANZ Journal of Surgery

View full text Add to dashboard Cite

Background High‐quality colonoscopy is vital for the detection and removal of adenomatous polyps and early diagnosis of colorectal cancer. The aim of this study was to prospectively assess the quality and safety of colonoscopies performed in the non‐metropolitan setting. Key performance indicators measured include completion, polypectomy and adenoma/serrated polyp detection rates, rate of adequate bowel preparation, withdrawal time and complications. Methods Prospective data collection for all colonoscopies performed over a one‐year period in seven non‐metropolitan South Australian hospitals. Two general surgeons and twelve registrars working in rural South Australian hospitals (Mount Gambier, Millicent, Naracoorte, Port Lincoln, Port Augusta, Whyalla and Berri) contributed to this study. Results In total 3497 colonoscopies were analysed. Complete colonoscopy was achieved in 96.1%. The adenoma detection and serrated polyp detection rates were 25.6% and 5.4% respectively. Cancer was detected in 71 patients (2%). Colonic perforation occurred in five patients (0.1%). There was no procedure‐related mortality. Conclusions Colonoscopy performed in the non‐metropolitan Australian setting outperforms key performance indicators set by national institutions. This is the first Australian prospective multi‐centre study investigating the quality and safety of endoscopic procedures.

show abstract

Section: Discussionmentioning

confidence: 60%

Quality of rural colonoscopy outperforms key performance indicators in a multi‐centre prospective clinical study

Watson

Maddern

et al. 2022

ANZ Journal of Surgery

View full text Add to dashboard Cite

show abstract

“…Therefore, if a particular indication was associated with adenoma detection, this would likely associate with SSL detection regardless of whether it was an independent covariate. Significantly, FIT status was not associated with SSL detection, consistent with the fact that SSLs rarely bleed [4,16]. This means that while some studies support earlier initiation of FIT for increasing rates of CRC in average-risk patients < 50 years, such an approach may provide inadequate protection for females < 50 years who may be more susceptible to SSLs [3].…”

Section: Colonoscopy Indicationmentioning

confidence: 66%

“…This variability in sex association is observed regardless of geographical region. Australian studies have reported either no association with sex or association with female sex [16,23]. On the other hand, European studies report either no association or association with the male sex [24,25].…”

Section: Age and Sexmentioning

confidence: 96%

“…There are several potential reasons why our study, and others, exhibit considerable variability in SSL sex associations and SSL prevalence. Firstly, the dates of publication of the above studies range from 2008 to 2019, suggesting that different histopathological criteria have been used to identify SSLs [14,16,[23][24][25][26][27][28]. The most recent SSL histopathological criteria are more sensitive than those used previously, possibly contributing to our relatively highobserved prevalence.…”

Section: Age and Sexmentioning

confidence: 99%

“…There is also ongoing controversy regarding risk factors associated with SSLs, with high variability seen for both endoscopist SSL detection rate and histopathological identification [4,[13][14][15][16][17]. Factors contributing to these inconsistencies include (a) the flat morphology of SSLs and their frequent location in the proximal colon, (b) periodic updates of SSL histopathological diagnostic criteria by the WHO, most recently in 2019, and (c) the fact that SSLs rarely bleed, resulting in low detection utilising the faecal immunochemical test (FIT) as a sole screening tool [4,15,18].…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Disparate age and sex distribution of sessile serrated lesions and conventional adenomas in an outpatient colonoscopy population–implications for colorectal cancer screening?

Lall

Ismail

Ayonrinde

2022

Int J Colorectal Dis

Self Cite

View full text Add to dashboard Cite

Purpose Colorectal cancer (CRC) is increasingly diagnosed in individuals aged < 50 years, resulting in advocacy of screening from age 45 years. Despite existing knowledge associating CRC with conventional adenomas, the significance of sessile serrated lesions (SSLs) on the burden of CRC is less detailed. We aimed to provide contemporary estimates for SSL prevalence and examine patient and procedure factors associated with SSL detection. Methods Retrospective observational study examining associations between SSL and conventional adenoma detection, polyp histopathology, patient, and procedure characteristics in an outpatient colonoscopy unit over 12 months. Results From 2097 colonoscopies, SSL detection was 13.8% overall and 12.5% in patients < 50 years. SSLs were mostly proximal in location (64%), and SSL detection was significantly higher in females compared with males (16.2% vs. 11.7%, p = 0.003), particularly in those < 50 years (16.8% vs. 8.6%, p < 0.001). In multivariable analysis, SSL detection was associated with female sex (adjusted odds ratio [aOR] 1.48, 95% confidence interval [CI] 1.15–1.91), synchronous conventional adenoma detection (aOR 1.36, 95% CI 1.04–1.78) and BMI ≥ 25 kg/m2 (aOR 1.34, 95% CI 1.02–1.77). Conventional adenoma detection was 33.6% and associated with age ≥ 50 years (aOR 3.57, 95% CI 2.84–4.47) and synchronous SSL detection (aOR 1.36, 95% CI 1.03–1.79). Conclusions We observed age and sex disparities in polyp types and prevalence in this outpatient colonoscopy population. SSLs were most prevalent in females aged < 50 years, suggesting a potential increased susceptibility of young females to SSLs and CRC. Our findings may have implications for the design of CRC screening programs.

show abstract

Colorectal adenomatous and serrated polyps in rural South Australia: who, why, what and where?

Watson,

Maddern

et al. 2023

ANZ Journal of Surgery

View full text Add to dashboard Cite

BackgroundsThe adenoma‐carcinoma and serrated pathways offer a window of opportunity for the removal of pre‐malignant polyps and prevention of colorectal cancer (CRC) through the use of colonoscopy. The aim of this study was to investigate variation in polyp incidence in different age groups, gender and indications for undertaking colonoscopy. We also address histological types of polyps found and where in the bowel they are located.MethodsThis study is based on the colonoscopy data collected prospectively over a one‐year period in multiple South Australian rural centres, 24 general surgeons contributed to this study. All histopathology results were subsequently entered into the dataset.ResultsA total of 3497 colonoscopies were performed, with a total of 2221 adenomatous and serrated polyps removed. Both serrated and adenomatous polyps were more common in the distal colon. Patients of male gender, aged 70 years and over and with an indication of polyp surveillance had higher adenoma and serrated polyp detection rates (ADR and SPDR). Patients aged 40–49 years old who underwent colonoscopy for positive faecal occult blood had an ADR and SPDR of 25.0% and 6.3%, respectively.ConclusionsThis study has shown variation in ADR and SPDR depending on age, gender and indication for colonoscopy. This variation will help further develop key performance indicators in colonoscopy. The high ADR and SPDR in patients aged 40–49 years old whom underwent colonoscopy for positive faecal occult blood may support lowering the age of commencement of CRC screening in Australia.

show abstract

Should the high prevalence of sessile serrated lesions in patients aged below 50 years influence screening colonoscopy recommendations?

Cited by 3 publications

References 7 publications

Quality of rural colonoscopy outperforms key performance indicators in a multi‐centre prospective clinical study

Quality of rural colonoscopy outperforms key performance indicators in a multi‐centre prospective clinical study

Disparate age and sex distribution of sessile serrated lesions and conventional adenomas in an outpatient colonoscopy population–implications for colorectal cancer screening?

Colorectal adenomatous and serrated polyps in rural South Australia: who, why, what and where?

Contact Info

Product

Resources

About