2021
DOI: 10.1016/j.ygyno.2020.11.034
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Should the risk for uterine cancer influence decision making for prophylactic hysterectomy in BRCA1/2 mutated patients- a systematic review and meta-analysis

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Cited by 17 publications
(13 citation statements)
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“…Hence, while RRSO is a well-established procedure for women with BRCAm at 35–40 years of age for BRCA1m and at 40–45 years for BRCA2m [ 2 ], prophylactic hysterectomy at the time of RRSO is still a matter of debate [ 16 ]. If women carrying BRCA1m are confirmed to be at an increased risk for serous or serous-like endometrial cancer, this should be considered when counselling a patient with regards to the risks and benefits of the addition of hysterectomy at the time of RRSO.…”
Section: Introductionmentioning
confidence: 99%
“…Hence, while RRSO is a well-established procedure for women with BRCAm at 35–40 years of age for BRCA1m and at 40–45 years for BRCA2m [ 2 ], prophylactic hysterectomy at the time of RRSO is still a matter of debate [ 16 ]. If women carrying BRCA1m are confirmed to be at an increased risk for serous or serous-like endometrial cancer, this should be considered when counselling a patient with regards to the risks and benefits of the addition of hysterectomy at the time of RRSO.…”
Section: Introductionmentioning
confidence: 99%
“…In our previous publication, we identified that 15.7% of USC patients included in our study were carriers of BRCA germline mutations, and 25.5% of our relatively small USC cohort were previously found to have a personal history of breast carcinoma [5], suggesting a possible association between breast cancer (BC) and USC. In addition, in our recent metaanalysis, we have shown an elevated risk for EC and especially USC among patients with BRCA germline mutations [7].…”
Section: Introductionmentioning
confidence: 81%
“…Prophylactic oophorectomy for BRCA mutation carriers is strongly recommended [22,23]; however, the issue of prophylactic hysterectomy in this unique population is still controversial and should be discussed positively [7]. The NCCN guidelines for BC patients which are not BRCA mutations carriers include surveillance only, and prophylactic oophorectomy is considered only in rare/special cases [24].…”
Section: Discussionmentioning
confidence: 99%
“…A risk-reducing bilateral salpingooophorectomy (without hysterectomy) was also offered to the patient, but the patient opted for hysterectomy in large part due to knowledge of her sister's advanced ovarian carcinoma. Emerging evidence indicates that the risk of serous uterine cancer is increased in BRCA1/ BRCA2 mutation carriers, supporting the consideration to perform hysterectomy on an individual basis for highrisk patients (11,12). Larger data series that include RAD51D mutations, and/or other moderate-risk variants, are needed to guide optimal surgery for this category of familial risk.…”
Section: Discussionmentioning
confidence: 99%