Should the UK introduce a universal childhood varicella vaccination programme?

Amirthalingam, Gayatri; Ramsay, Mary

doi:10.1136/archdischild-2015-308730

Cited by 7 publications

(9 citation statements)

References 11 publications

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“…In the United States (US), illicit drug use (specifically opioid use disorder) among pregnant women has increased almost four-fold between 2004 and 2012, with at least one infant born with signs of withdrawal or neonatal opioid withdrawal syndrome (NOWS), formerly known as neonatal abstinence syndrome (NAS), every 15 min [ 1 , 2 , 3 ]. Similar trends in the rate of NOWS have also been reported in other countries, including the United Kingdom and Canada [ 4 , 5 , 6 ].…”

Section: Introductionsupporting

confidence: 81%

Economic Evaluation of Interventions for Treatment of Neonatal Opioid Withdrawal Syndrome: A Review

et al. 2021

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This study assessed the economic evidence on the pharmacological and non-pharmacological management of infants with neonatal opioid withdrawal syndrome (NOWS). Six databases were searched up to October 2020 for peer-reviewed studies. After titles and abstracts were screened, 79 studies remained for full-text review, and finally, 8 studies were eligible for inclusion in the review. The methodological quality of included studies was assessed using the Drummond checklist. The review showed significant limitations in these studies, with one study being rated as good and the remaining seven studies as of poor quality. There are methodological issues that require addressing, including a lack of detail on cost categories, a robust investigation of uncertainty, and extending the time horizon to consider longer-term outcomes beyond the initial birth hospitalization. Despite these limitations, existing evidence suggests non-pharmacological strategies such as rooming-in were associated with a shorter hospital stay and a decreased need for pharmacological treatment, thereby lowering hospitalization costs. The review highlights the paucity of high-quality studies assessing the cost-effectiveness of intervention strategies for NOWS. There is also a lack of evidence on long-term outcomes associated with NOWS and the treatment of NOWS. The inclusion of economic analyses in future studies will provide evidence to inform policymakers on resource allocation decisions for this patient population.

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Section: Introductionsupporting

confidence: 81%

Economic Evaluation of Interventions for Treatment of Neonatal Opioid Withdrawal Syndrome: A Review

et al. 2021

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“…Several other countries, including Uruguay, Germany, and Australia, have adopted similar immunization programs 13,34 . Other countries like the UK have a selective vaccination policy which means that immunization is only offered to high risk groups such as non-immune health care workers and household contacts of the immuno-suppressed 15 .…”

Section: Literature Reviewmentioning

confidence: 99%

“…Introduction of the vaccine has led to significant reductions in varicella incidence, morbidity, mortality, hospitalisations and ambulatory visits in the population and in vulnerable groups 11,12,13 . Thus, some countries are reviewing the evidence for universal varicella immunization in their own setting 14,15 . This review looks at the evidence for universal varicella immunization in an African country, like Ghana.…”

Section: Introductionmentioning

confidence: 99%

Chickenpox In Ghana; Is It Time To Consider Universal Immunization?

Addai¹,

Tette²

2022

pmjg

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Chickenpox is a very common disease worldwide. It is one of the most frequently reported infectious diseases in North America. Although childhood varicella disease is not usually a life-threatening condition, it can cause major financial and social problems to parents and society from lost working time spent looking after sick children. Besides, there is a large number of unrecognized complications including fatalities from invasive infections. The availability of an effective vaccine, has made universal immunization a cost-effective approach to prevention and minimizing the effects of the disease in some settings. The exact burden of the disease in Ghana and for that matter most of Africa is unknown. Thus, in Ghana, a surveillance system and selective immunization is recommended as more information is gathered on the burden of disease and its impact on Ghana and the rest of Africa.

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“…Children in the UK are not routinely vaccinated against varicella, due to the relatively mild course of disease for most individuals and previous cost-benefit analyses 20 21. A herpes zoster vaccine has been recommended in those above 70 years since 2013 2.…”

Section: Vaccinationmentioning

confidence: 99%

Fifteen-minute consultation: Prevention and treatment of chickenpox in newborns

Holland

Sadarangani

2019

Arch Dis Child Educ Pract Ed

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There are inconsistencies in how newborns are managed following exposure to varicella, ranging from reassurance and observation to administration of varicella zoster immunoglobulin (VZIG) and admission to hospital for varying length courses of intravenous aciclovir.Hospitalised preterm babies exposed to varicella should receive VZIG. Administration can otherwise be limited to pregnant non-immune women or to newborns if there is development of maternal chickenpox from 5 days prior to delivery up to 48 hours postdelivery. Intravenous aciclovir is only recommended in cases of newborn disease despite VZIG or in severe disease. The use of VZIG may not prevent varicella but may reduce severity of disease.In this article, we review the evidence for risk to non-immune mothers, the fetus and newborns who had different types of exposure to varicella, with recommendations for management and treatment of confirmed neonatal chickenpox.

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Should the UK introduce a universal childhood varicella vaccination programme?

Cited by 7 publications

References 11 publications

Economic Evaluation of Interventions for Treatment of Neonatal Opioid Withdrawal Syndrome: A Review

Economic Evaluation of Interventions for Treatment of Neonatal Opioid Withdrawal Syndrome: A Review

Chickenpox In Ghana; Is It Time To Consider Universal Immunization?

Fifteen-minute consultation: Prevention and treatment of chickenpox in newborns

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