Should we assume that hypothermia is a dysfunction in sepsis?

Steiner, Alexandre A.; Fonseca, Monique T.; Soriano, Francisco

doi:10.1186/s13054-016-1584-y

Cited by 13 publications

(12 citation statements)

References 7 publications

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“…One may consider LPS-induced hypothermia as a failure in neural control of Tb. Alternatively, recent studies have suggested that hypothermia is precisely controlled by specific mechanisms mediated by the central nervous system 35 . Based on these data, we suggest that baroreceptor afferents integrity affect thermoregulatory control during SI by impairing a key part of the afferent signals to the brain.…”

Section: Discussionmentioning

confidence: 99%

Baroreceptor denervation reduces inflammatory status but worsens cardiovascular collapse during systemic inflammation

Amorim

Deus

Pereira

et al. 2020

Sci Rep

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Beyond the regulation of cardiovascular function, baroreceptor afferents play polymodal roles in health and disease. Sepsis is a life-threatening condition characterized by systemic inflammation (SI) and hemodynamic dysfunction. We hypothesized that baroreceptor denervation worsens lipopolysaccharide (LPS) induced-hemodynamic collapse and SI in conscious rats. We combined: (a) hemodynamic and thermoregulatory recordings after LPS administration at a septic-like non-lethal dose (b) analysis of the cardiovascular complexity, (c) evaluation of vascular function in mesenteric resistance vessels, and (d) measurements of inflammatory cytokines (plasma and spleen). LPS-induced drop in blood pressure was higher in sino-aortic denervated (SAD) rats. LPS-induced hemodynamic collapse was associated with SAD-dependent autonomic disbalance. LPS-induced vascular dysfunction was not affected by SAD. Surprisingly, SAD blunted LPS-induced surges of plasma and spleen cytokines. These data indicate that baroreceptor afferents are key to alleviate LPS-induced hemodynamic collapse, affecting the autonomic control of cardiovascular function, without affecting resistance blood vessels. Moreover, baroreflex modulation of the LPS-induced SI and hemodynamic collapse are not dependent of each other given that baroreceptor denervation worsened hypotension and reduced SI.

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Section: Discussionmentioning

confidence: 99%

Baroreceptor denervation reduces inflammatory status but worsens cardiovascular collapse during systemic inflammation

Amorim

Deus

Pereira

et al. 2020

Sci Rep

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“…Hypothermia was considered a failure of the thermoregulatory effectors during severe SI. More recently, this notion has been reconsidered by studies documenting that specific thermoregulatory mechanisms take place in SI to induce hypothermia [ 72 ]. In the present study, we observed that citral enhanced hypothermia.…”

Section: Discussionmentioning

confidence: 99%

“…In the present study, we observed that citral enhanced hypothermia. Since hypothermia is now accepted as an adaptive response when the costs of fever exceed its benefits [ 72 ], we believe that citral has a potential to be therapeutically used as a drug to induced regulated hypothermia.…”

Section: Discussionmentioning

confidence: 99%

Hypothermic Effect of Acute Citral Treatment during LPS-induced Systemic Inflammation in Obese Mice: Reduction of Serum TNF-α and Leptin Levels

et al. 2020

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Citral is a mixture of monoterpenes present in the essential oil of several plants, such as Cymbopogon citratus and Zingiber officinale, possessing anti-inflammatory, anti-ulcerogenic, and antipyretic actions. We investigated the action of citral on body temperature (Tb) and inflammatory signaling in eutrophic and obese mice during Systemic Inflammation (SI) induced by Lipopolysaccharide (LPS). Thus, we assessed the effect of citral (25, 100, and 300 mg/kg) and ibuprofen in LPS-induced SI in Swiss male mice fed a standard diet (SD) or high-fat diet (HFD) for 12 weeks. Following SI induction, we measured Tb and collected the serum, hypothalamus, and gastric mucosa for biochemical measurements. Acute treatment with citral decreased the Tb of both SD and HFD-fed animals. Citral (300 mg/kg) treatment caused a significantly lower Tb variation in HFD-fed animals than in those fed the SD. Citral reduced peripheral levels of tumor necrosis factor (TNF)-α in SD and HFD mice and decreased serum leptin concentration in HFD mice 90 min after the LPS challenge. Furthermore, citral also reduced interleukin (IL)-6 levels in the hypothalamus of obese mice. In summary, citral effectively reduced Tb during SI by reducing inflammatory mediators with a distinct action profile in HFD mice when compared with SD.

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“…One may consider LPS-induced hypothermia as a failure in neural control of Tb. Alternatively, recent studies have suggested that hypothermia is precisely controlled by specific mechanisms mediated by the central nervous system (37). Based on these data, we suggest that baroreceptor afferents integrity affect thermoregulatory control during SI by impairing a key part of the afferent signals to the brain.…”

Section: Discussionmentioning

confidence: 99%

Baroreceptor denervation reduces inflammatory status and worsens cardiovascular collapse during systemic inflammation

Amorim

Deus

Pereira

et al. 2019

Preprint

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ABSTRACTBeyond the regulation of cardiovascular function, baroreceptor afferents play polymodal roles. We hypothesized that baroreceptor denervation affects lipopolysaccharide (LPS)-induced systemic inflammation (SI) and hemodynamic collapse in conscious rats, and that these parameters are interconnected. We combine: a) hemodynamic and thermoregulatory recordings after LPS administration at a septic-like dose b) analysis of the cardiovascular complexity, c) evaluation of vascular function in mesenteric resistance vessels, and d) measurements of inflammatory cytokines (plasma and spleen). LPS-induced drop in blood pressure was higher in sino-aortic denervated (SAD) rats. LPS-induced hemodynamic collapse was associated with SAD-dependent autonomic disbalance. LPS-induced vascular dysfunction was not affected by SAD. Surprisingly, SAD blunted LPS-induced surges of plasma and spleen cytokines. These data indicate that sino-aortic afferents are key to alleviate LPS-induced cardiovascular collapse, affecting the autonomic cardiovascular control, without affecting resistance blood vessels. Moreover, baroreflex modulation of the LPS-induced SI and hemodynamic collapse seem not to be interconnected.

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Should we assume that hypothermia is a dysfunction in sepsis?

Cited by 13 publications

References 7 publications

Baroreceptor denervation reduces inflammatory status but worsens cardiovascular collapse during systemic inflammation

Baroreceptor denervation reduces inflammatory status but worsens cardiovascular collapse during systemic inflammation

Hypothermic Effect of Acute Citral Treatment during LPS-induced Systemic Inflammation in Obese Mice: Reduction of Serum TNF-α and Leptin Levels

Baroreceptor denervation reduces inflammatory status and worsens cardiovascular collapse during systemic inflammation

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