Should we change reference range for serum albumin in major gastrointestinal surgery? Preoperative serum albumin as an important prognostic factor

Czempik, Piotr F.; Czepczor, Kinga; Czok, Marcelina Z

doi:10.1177/1750458919875583

Cited by 2 publications

(1 citation statement)

References 15 publications

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“…Pre-operative total serum protein level has been a predictor/prognostic factor in adult patients. [25][26][27] Malnutrition can lead to lower protein reserves, which may affect normal healing, and can hinder the ability to recover after surgical intervention. Serum total protein is an indication of the circulating amount of albumin and globulin.…”

Section: Discussionmentioning

confidence: 99%

Pre-operative nutritional status and its association with short-term post-operative outcomes in Iranian children with CHD

et al. 2022

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Background: Nutritional assessment appears to be an essential component of the evaluation of children with CHD undergoing surgery because nutritional status may impact corrective surgery-associated morbidity. Methods: A prospective single-centre cohort study with children between 6 and 24 months of age. Patients who had genetic syndromes or those who were premature or low birthweight at birth were excluded. Pre-operative nutritional parameters included anthropometric measurements and serum concentrations of total protein, vitamin D, iron, and ferritin. Outcome measures included ICU length of stay, mechanical ventilation, vasoactive-inotropic score, and duration of inotropes. Linear regression analysis was performed to determine whether pre-operative variables were associated with outcomes. Results: Analysis was performed on 120 patients (median age of 8 months), of whom 67 were male. Prior to surgery, 50.8% of patients had reduced (z ≤ −2.0) weight-for-age z score, 23.3% had reduced length-for-age z score, and 59.2% had reduced mid-upper arm circumference z score. Pre-operative serum total protein levels were 59.36 ± 9.16 g/L. Multiple regression analysis showed that low serum protein was associated with longer ICU length of stay and length of mechanical ventilation, while mid-upper arm circumference z score ≤ −2 was associated with longer ICU length of stay and mechanical ventilation and inotropes duration. Conclusions: Pre-operative assessment of nutritional status by performing anthropometric and biochemical measurements including mid-upper arm circumference z score and serum protein concentrations in children undergoing CHD surgery appears to be predictors of some post-operative short-term outcomes and could be used as a guide to highlight patients needing appropriate perioperative nutritional interventions.

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Section: Discussionmentioning

confidence: 99%