Should we mind for late neurologic manifestations from novel coronavirus?

André, Ana; Félix, Catarina; Nzwalo, Hipólito

doi:10.1016/j.clineuro.2020.106021

Cited by 2 publications

(2 citation statements)

References 5 publications

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“…11 Headache has been the most common neurological complaint (14%), 8 along with other nonspecific subjective symptoms of concentration difficulties, subjective memory loss, reduced attention span, and even delirium, the latter noted predominantly in hospitalized populations. [12][13][14][15][16] Longer-term sequelae of SARS-CoV-2 infection involving outpatients have not been described as thoroughly. A recent longitudinal prospective cohort study 17 tracked chronic symptoms in a cohort of 234 patients who had COVID-19 residing in the Pacific Northwestern United States.…”

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confidence: 99%

Post–COVID-19 Syndrome (Long Haul Syndrome): Description of a Multidisciplinary Clinic at Mayo Clinic and Characteristics of the Initial Patient Cohort

Vanichkachorn

Newcomb

Cowl

et al. 2021

Mayo Clinic Proceedings

164

121

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Objective To describe characteristics of a series of patients reporting prolonged symptoms after an infection with COVID-19. Methods This study describes the multidisciplinary COVID-19 Activity Rehabilitation Program (CARP), established at Mayo Clinic to evaluate and treat post-COVID-19 syndrome (PCS) patients, and reports the clinical characteristics of the first 100 patients receiving evaluation and management during the timeframe of June 1, 2020 and December 31, 2020. Results The cohort consisted of 100 patients (mean age 45 years, 68% women, BMI 30.2, presenting a mean of 93 days after infection). Common pre-existing conditions were respiratory (23%) and mental health, including depression and/or anxiety (34%.) The majority (75%) had not been hospitalized for COVID-19. Common presenting symptoms ware fatigue (80%), respiratory complaints (59%), and neurologic complaints (59%) followed by subjective cognitive impairment, sleep disturbance, and mental health symptoms. More than one-third of the patients (34%) reported difficulties with performing basic activities of daily living. Only 1 in 3 patients had returned to unrestricted work duty at the time of the analysis. For most patients, laboratory and imaging studies were normal or non-diagnostic despite debilitating symptoms. Most patients required physical therapy, occupational therapy, or brain rehabilitation. Face-to-face and virtual care delivery modalities were feasible. Conclusion Many of the patients did not experience COVID-19-related symptoms that were severe enough to require hospitalization, were younger than 65 years of age, more likely to be female, and most had no pre-existing comorbidities prior to SARS-CoV-2 infection. Symptoms including mood disorders, fatigue, and perceived cognitive impairment resulted in severe negative impacts on resumption of functional and occupational activities in patients experiencing prolonged effects.

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confidence: 99%

Post–COVID-19 Syndrome (Long Haul Syndrome): Description of a Multidisciplinary Clinic at Mayo Clinic and Characteristics of the Initial Patient Cohort

Vanichkachorn

Newcomb

Cowl

et al. 2021

Mayo Clinic Proceedings

164

121

View full text Add to dashboard Cite

show abstract

“…Headache is also reported in recovered COVID-19 individuals. Headache is also the most common neurological symptom in individual with long COVID-19, along with other complaints such as impaired concentration and memory [2,[10][11][12][13]. Mendelson et al proposed that a headache that lasts at least six months, whether as a single clinical symptom, co-occurring with other cognitive disorders such as "brain fog" or exacerbating pre-existing migraine symptoms should be suspected of being caused by long COVID-19 [14].…”

Section: Introductionmentioning

confidence: 99%

A comparison study of headache characteristics and headache-associated quality-of-life of COVID-19 and non-COVID-19 patients

Mutiawati

Kusuma

Fathima

et al. 2022

Narra J

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Headache is prevalent in coronavirus disease 2019 (COVID-19) patients. The main objective of this study was to compare the characteristics of COVID-19-associated headache to non-COVID-19 headache. The quality-of-life (QoL) and its associated determinants between COVID-19 and non-COVID-19 patients were also compared. A cross-sectional study was conducted in Banda Aceh, Indonesia. Headache and QoL were assessed using the International Classification of Headache Disorders, version 3 (ICHD-3), and the 36-item Short Form Health Survey (SF-36), respectively. Factors associated with poor QoL in COVID-19 and non-COVID-19 patients were examined using logistic regression. A total of 356 headache patients were included: 215 COVID-19 and 141 non-COVID-19 patients. Our data suggested that the headache in COVID-19 patients was bilateral; pain centered on one specific area with a pulsating or pressing sensation; pain intensity ranging from moderate to severe; and the frequency ranging from more than twice per week to every day. Non-COVID-19 headache was bilateral; pain centered on one side of the head resembling a migraine with pulsating or pressing sensation; mild to moderate pain intensity; and the frequency of one or two times per month. In COVID-19, low QoL was associated with unemployment status, having non-health-related jobs, having used painkillers to reduce the pain, having long duration of headache, having more frequency of attacks, and having headaches that were worsened by activities or light, and having additional symptom during a headache attach. In non-COVID-19 patients, poor QoL was associated with the use of painkillers, long duration of headache, and having conditions that aggravate the headache. To prevent long-term effects of headache associated with COVID-19, studies exploring the photobiology of headache are needed, along with the necessity of having standardised guideline on headache prevention.

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Should we mind for late neurologic manifestations from novel coronavirus?

Cited by 2 publications

References 5 publications

Post–COVID-19 Syndrome (Long Haul Syndrome): Description of a Multidisciplinary Clinic at Mayo Clinic and Characteristics of the Initial Patient Cohort

Post–COVID-19 Syndrome (Long Haul Syndrome): Description of a Multidisciplinary Clinic at Mayo Clinic and Characteristics of the Initial Patient Cohort

A comparison study of headache characteristics and headache-associated quality-of-life of COVID-19 and non-COVID-19 patients

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