Should women with atypical squamous cells, cannot exclude high-grade squamous intraepithelial lesion, receive reflex human papillomavirus-DNA testing?

Liman, Agnes K.; Giampoli, Ellen; Bonfiglio, Thomas A.

doi:10.1002/cncr.21387

Cited by 46 publications

(44 citation statements)

References 43 publications

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“…In the recent study by Kingnate et al (2014), incidence of CIN 2-3/AIS and invasive lesion was 10.5% and 2.6%, respectively. In the literature, almost all studies evaluating histopathologic results of ASC-H smears were reported from North America where the incidence of cervical cancer appears to be relatively low (Alli and Ali, 2003;Louro et al, 2003;Selvaggi, 2003;Liman et al, 2005;Barreth et al, 2006;Saad et al, 2006;Srodon et al, 2006;McHale et al, 2007). The rate of underlying high-grade cervical lesion varied widely from 10% to 80%, in which less than 3.5% were invasive lesion (Alli and Ali, 2003;Louro et al, 2003;Selvaggi, 2003;Liman et al, 2005;Barreth et al, 2006;Saad et al, 2006;Srodon et al, 2006;McHale et al, 2007).…”

Section: Atypical Squamous Cells Cannot Exclude High-grade Squamous mentioning

confidence: 99%

Histopathological Outcomes of Women with Abnormal Cervical Cytology: a Review of Literature in Thailand

Kietpeerakool¹,

Tangjitgamol²,

Srisomboon³

2014

Asian Pacific Journal of Cancer Prevention

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Asian Pac J Cancer Prev, 15 (16), 6489-6494 IntroductionCervical cancer remains the major health problem in Thailand and many other developing countries. This is mainly because of failure to initiate or sustain effective screening strategy. In recent population-based cancer registries, the highest incidence of cervical cancer in Thailand was noted in Chiang Mai with an average agestandardized incidence rate (ASR) of 28.9 per 100000, followed by Lampang (ASR, 22.4) and Bangkok (ASR, 20.9) (Moore et al., 2010).Although high-risk Human Papillomavirus (HR-HPV) test and HPV genotyping have certain role in cervical cancer screening nowadays, these tests are not widely available in developing countries. Cervical cytology is still the principal screening method. Subsequent management of abnormal cervical cytology to detect underlying cervical lesions is also important. Generally, management of abnormal cervical cytology depends on the risk of encountering high-grade cervical disease. However, the risks of high-grade cervical disease encountered in abnormal cervical cytology may vary among different regions of the world and across the country. Therefore, information regarding the incidence of significant cervical disease from different areas or populations is crucial for designing and implementing area-specific management approach. This review was conducted to evaluate the incidence of high-grade cervical diseases among Thai AbstractCervical cytology remains the principal screening method to detect pre-invasive and invasive cervical lesions. Management of abnormal cervical cytology depends on the risk of encountering a significant cervical lesion or high-grade cervical disease. These risks may vary in different areas across the country. Thus, determining the rate of significant cervical lesion associated with each type of abnormal cervical cytology in each area is of critical importance for designing area-specific management approach. This review was conducted to evaluate the rate of high-grade cervical disease among Thai women with abnormal cervical cytology. A relatively high incidence of underlying significant lesions including invasive disease was demonstrated even in those having only minimal smear abnormality. This baseline information is crucial and must be taken into consideration in management of women with abnormal cytological screening to achieve the goals of comprehensive cervical cancer control in Thailand.

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Section: Atypical Squamous Cells Cannot Exclude High-grade Squamous mentioning

confidence: 99%

Histopathological Outcomes of Women with Abnormal Cervical Cytology: a Review of Literature in Thailand

Kietpeerakool¹,

Tangjitgamol²,

Srisomboon³

2014

Asian Pacific Journal of Cancer Prevention

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“…Accumulating evidence from several studies over the past few years supports the role of reflex HPV DNA testing in the initial diagnostic approach for patients with ASC-H on cytology, although many of these previous studies included only limited cases with ASC-H and HPV-negative results [12][13][14][20][21][22][23][24]. These previous studies reported NPVs of .90% of HPVnegative results accompanying ASC-H for predicting highgrade CIN lesions (CIN $2), consistent with the NPV of 91.2% obtained in the present study.…”

Section: Discussionmentioning

confidence: 99%

Reflex Human Papillomavirus Test Results as an Option for the Management of Korean Women With Atypical Squamous Cells Cannot Exclude High-Grade Squamous Intraepithelial Lesion

et al. 2015

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Background. Current guidelines recommend initial colposcopy with biopsy regardless of human papillomavirus (HPV) test results in women with atypical squamous cells, cannot exclude high-grade squamous intraepithelial lesion (ASC-H). The purpose of this study was to evaluate the value of HPV testing in women with ASC-H based on colposcopic pathology results. Materials and Methods. A multicenter cross-sectional study was carried out at three academic hospitals and involved 40,847 Korean women who underwent cervical cancer screening with cytology and HPV tests with or without subsequent colposcopic biopsies between January 2007 and December 2013. Results. ASC-H was diagnosed in 276 women (0.7%). Only 6 of 68 (8.8%) women with ASC-H who were HPV negative had cervical intraepithelial neoplasia grade $2 (CIN $2) lesions, whereas

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“…5 For ASCH, the recommended management is colposcopy. However, Liman et al 21 in 2005 and Wu et al in 2006 22 suggested that reflex HPV-DNA testing may also serve to better select patients with ASCH who should undergo colposcopic examination. Nevertheless, in our experience, 1 woman with ASCUS and 3 women with ASCH had a CIN21 at the histologic control and were initially negative for HR-HPV testing.…”

Section: Discussionmentioning

confidence: 99%

“…Today, the recommendations for management of women with ASCH are colposcopy and biopsy. However, if, as suggested by Liman et al 21 and Wu et al, 22 reflex HR-HPV testing is used for the triage of women with ASCH, the presence of 9c-exceeding cells should refine this triage by helping to detect women with an underlying CIN21.…”

Section: Discussionmentioning

confidence: 99%

Contribution of DNA ploidy image cytometry to the management of ASC cervical lesions

Lee

Caudroy

Nou

et al. 2008

Cancer

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BACKGROUND. The Bethesda system classifies smears that suggest an underlying cervical intraepithelial neoplasia (CIN) as ASC (atypical squamous cell) smears. ASC smears are subdivided into ASCUS (of undetermined significance) and ASCH (cannot exclude a high‐grade lesion). Today the management of ASCUS is a triage with HR‐HPV testing and colposcopy is recommended for ASCH. The aim was to conduct a study on ASC smears to determine DNA ploidy measurement for the detection of CIN2+. METHODS. The link between a suspect DNA ploidy assessed by image cytometry and/or a positive HR‐HPV testing was analyzed on 69 ASCUS and 82 ASCH smears, and the presence of CIN2+ within 12 months after ASC diagnosis. The ploidy was suspect in case of aneuploidy, multiploidy, or in the presence of cells with a DNA content >5c or >9c. RESULTS. Every woman who had a CIN2+ had a suspect DNA profile in the ASCUS smears and every woman except 1 was HR‐HPV‐positive. The link between a positive HR‐HPV test or a suspect DNA profile or both and a CIN2+ was high (P = .019, .023, and .008, respectively). The presence of >9c cells was particularly linked to CIN2+ (P = .0031). In all, 90.9% and 87.9% of the ASCH smears with CIN2+ were, respectively, HR‐HPV positive or had a suspect ploidy (P = .0000 and P = .0043), and the presence of >9c cells was also linked to CIN2+ (P = .003). CONCLUSIONS. HR‐HPV testing and determination of the ploidy profile with special attention to 9c‐exceeding cells could be accurate for a better management of ASC smears. Cancer (Cancer Cytopathol) 2008. © 2008 American Cancer Society.

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Should women with atypical squamous cells, cannot exclude high-grade squamous intraepithelial lesion, receive reflex human papillomavirus-DNA testing?

Cited by 46 publications

References 43 publications

Histopathological Outcomes of Women with Abnormal Cervical Cytology: a Review of Literature in Thailand

Histopathological Outcomes of Women with Abnormal Cervical Cytology: a Review of Literature in Thailand

Reflex Human Papillomavirus Test Results as an Option for the Management of Korean Women With Atypical Squamous Cells Cannot Exclude High-Grade Squamous Intraepithelial Lesion

Contribution of DNA ploidy image cytometry to the management of ASC cervical lesions

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