Shoutai Wan regulates glycolysis imbalance at the maternal-fetal interface in threatened abortion mice

Zhang, Li; Wang, Shuhui; Ma, Yanlin; Song, Yajing; Li, Dandan; Liang, Xiao; Hao, Yanzhi; Jiang, Min; Lv, Jingfang; Du, Hongyin

doi:10.1016/j.jep.2023.116502

Cited by 13 publications

(7 citation statements)

References 34 publications

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“…St improved the level of glycolysis to reduce pregnancy loss rate. [ 9 ] Liuting Zeng, et al [ 10 ] identified HSP27, α-enolase and Transferrin as the therapeutic targets of St for TA via proteomics strategy and in vivo experiment. The effect of St associated with synaptic transmission, oxidation reduction process, gamma-aminobutyric acid signaling pathway, release of sequestered calcium ion into cytosol, and so on.…”

Section: Discussionmentioning

confidence: 99%

A case-control retrospective study for the effect of Shoutai Wan on IVF-ET pregnancy outcome

Liu,

Miao,

Lin

et al. 2024

Medicine

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It has a long history of preventing and treating disease using traditional Chinese medicine (TCM). In recent years, it has been widely used in adjuvant therapies of in vitro fertilization - embryo transfer (IVF-ET) in China. To observe the effect and safety of Shoutai Wan on pregnancy outcomes after IVF-ET. A total of 352 patients who underwent IVF-ET from July 1, 2020 to June 30, 2021. The participants who only received routine luteal support during clinical pregnancy of FET were defined as the control group, and others who received TCM decoction Shoutai Wan for prevention of miscarriage and routine luteal support were defined as the Chinese medicine protection Shoutai Wan group (St group). This project has been approved by the Ethics Committee of Run Run Shaw Hospital Affiliated to Zhejiang University School of Medicine (Approval NO: 2023-0305). The results of this retrospective cohort study revealed that Shoutaiwan combined with luteal support treatment can significantly decreased the miscarriage rate in pregnancy undergoing IVF-FET compared to the group accepted only luteal support treatment (P = .001). Meanwhile, St during pregnancy did not affect fetal birth weight (P = .354), and there was no adverse event in the St group reported, which confirmed the safety of TCM for fetus protection during pregnancy. This study not only provides evidences for the clinical administration of Shoutai Wan in IVF-ET, but also provides a novel direction for basic research into the subsequent innovative application of TCM.

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Section: Discussionmentioning

confidence: 99%

A case-control retrospective study for the effect of Shoutai Wan on IVF-ET pregnancy outcome

Liu,

Miao,

Lin

et al. 2024

Medicine

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“…Additionally, specific traditional Chinese medicines, like Shoutai Wan and Zhuyun III, can decrease the chances of pregnancy loss by modulating the glycolysis equilibrium at the maternal-fetal interface in kidney deficiency threatened abortion model mice. [ 14 ] For example, Shoutai Pill (composed of Sangsheng, Cuscuta, Dipsacus, ass hide glue) can regulate the expression of various proteins in decidua tissue of mice with recurrent abortion, and regulate the main signal pathways and biological processes of patients with recurrent abortion: regulate glucose metabolism and insulin resistance in decidua tissue; Regulating the VEGF signaling pathway; Improving hypoxia levels and oxidative stress in decidual tissue: Improving pre thrombotic state; Regulating the estrogen signaling pathway; Negative regulation of cell apoptosis in decidual tissue; Improving immune disorders: positively regulating T cell mediated cytotoxicity, T cell receptor signaling pathways, etc. [ 14 ] Traditional Chinese medicine Zhuyun No.3 (Cuscuta chinensis, Cinnamomum cassia, Fangfeng, Dipsacus, Astragalus membranaceus, and Codonopsis pilosula) can inhibit the secretion of Th1 cytokines, promote the secretion of Th2 cytokines, restore the pathological metastasis of Th1/Th2 balance, increase serum progesterone and β-HCG concentration.…”

Section: Discussionmentioning

confidence: 99%

Sanji Peiyuan decoction combined with dydrogesterone in the treatment of massive subchorionic hematoma: A case report

Yang,

Zheng,

et al. 2023

Medicine

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Rationale: Subchorionic Hematoma, often referred to as Bruce hematoma, can lead to serious obstetric complications such as intrauterine growth restriction and fetal death, as well as early and late pregnancy miscarriage, placental abruption, and premature rupture of membranes, posing great harm to both mother and fetus. Patient concerns: At present, Western medical treatments have not shown satisfactory results, necessitating the discovery of more effective clinical treatment methods. Diagnoses: Threatened miscarriage, Subchorionic hematoma, Iron deficiency anemia (mild). Interventions: Sanji Peiyuan decoction combined with dydrogesterone. Outcomes: Following 17 days of treatment with Sanji Peiyuan decoction and oral dydrogesterone tablets, the hematoma was no longer detectable by ultrasound. The patient experienced no symptoms such as abdominal pain, bloating, or vaginal bleeding. She successfully gave birth around her due date, with both the mother and child in good health. Lessons: The combination of Sanji Peiyuan decoction and oral dydrogesterone tablets shows promising clinical efficacy in treating Massive Subchorionic Hematomas. This method merits further clinical research.

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“…For example, Lv et al established a diabetic nephropathy (DN) mouse model and found that Fe 2+ was downregulated and SLC7A11, GPX4 content, and GSH/GSSG content, and GSH/GSSG were upregulated in the renal tissues of mice after San-Huang-Yi-Shen capsule (SHYS) administration and that it alleviated renal injury ( Su et al, 2021 ; Lv et al, 2023 ). At the same time, Modified Shoutai Pill , also known as Jianwei Shoutai Pill (JSP) , upregulated GSH, GPX4, downregulated MDA levels, and ACSL4 protein expression in the placenta of Recurrent Pregnancy Loss (RPL) mice, and was shown to protect against RSL3-induced lipid metabolism ( Zhang et al, 2023 ; Lai et al, 2024 ). Futhermore, Angong Niuhuang Wan (AGNHW) has recently been found to exert neuroprotective effects by modulating GPX4-related signaling pathways and inhibiting ferroptosis ( Bai et al, 2024 ).…”

Section: Small Molecule Ferroptosis Inhibitorsmentioning

confidence: 99%

Ferroptosis inhibitors: past, present and future

Zhang,

Luo,

Xiang

et al. 2024

Front. Pharmacol.

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Ferroptosis is a non-apoptotic mode of programmed cell death characterized by iron dependence and lipid peroxidation. Since the ferroptosis was proposed, researchers have revealed the mechanisms of its formation and continue to explore effective inhibitors of ferroptosis in disease. Recent studies have shown a correlation between ferroptosis and the pathological mechanisms of neurodegenerative diseases, as well as diseases involving tissue or organ damage. Acting on ferroptosis-related targets may provide new strategies for the treatment of ferroptosis-mediated diseases. This article specifically describes the metabolic pathways of ferroptosis and summarizes the reported mechanisms of action of natural and synthetic small molecule inhibitors of ferroptosis and their efficacy in disease. The paper also describes ferroptosis treatments such as gene therapy, cell therapy, and nanotechnology, and summarises the challenges encountered in the clinical translation of ferroptosis inhibitors. Finally, the relationship between ferroptosis and other modes of cell death is discussed, hopefully paving the way for future drug design and discovery.

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Shoutai Wan regulates glycolysis imbalance at the maternal-fetal interface in threatened abortion mice

Cited by 13 publications

References 34 publications

A case-control retrospective study for the effect of Shoutai Wan on IVF-ET pregnancy outcome

A case-control retrospective study for the effect of Shoutai Wan on IVF-ET pregnancy outcome

Sanji Peiyuan decoction combined with dydrogesterone in the treatment of massive subchorionic hematoma: A case report

Ferroptosis inhibitors: past, present and future

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